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Science 23 February 2001:
Vol. 291. no. 5508, pp. 1499 - 1502
DOI: 10.1126/science.291.5508.1499
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Perspectives

CELL CYCLE:
Centrioles at the Checkpoint

Andrew W. Murray

Cell biologists have long debated whether the cellular organelle called the centriole can be dispensed with during cell division. In a lively Perspective, Murray discusses new findings (Piel et al. and Hinchcliffe et al.) suggesting that centrioles play a part in new checkpoints that control cell division and the ability of divided cells to replicate their DNA.

The author is in the Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA. E-mail: amurray{at}mcb.harvard.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cell cycle progression and de novo centriole assembly after centrosomal removal in untransformed human cells.
Y. Uetake, J. Loncarek, J. J. Nordberg, C. N. English, S. La Terra, A. Khodjakov, and G. Sluder (2007)
J. Cell Biol. 176, 173-182
   Abstract »    Full Text »    PDF »
Inhibition of centrosome protein assembly leads to p53-dependent exit from the cell cycle.
V. Srsen, N. Gnadt, A. Dammermann, and A. Merdes (2006)
J. Cell Biol. 174, 625-630
   Abstract »    Full Text »    PDF »
PARP-3 localizes preferentially to the daughter centriole and interferes with the G1/S cell cycle progression.
A. Augustin, C. Spenlehauer, H. Dumond, J. Menissier-de Murcia, M. Piel, A.-C. Schmit, F. Apiou, J.-L. Vonesch, M. Kock, M. Bornens, et al. (2003)
J. Cell Sci. 116, 1551-1562
   Abstract »    Full Text »    PDF »


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