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Cell biologists have long debated whether the cellular organelle called the centriole can be dispensed with during cell division. In a lively Perspective, Murray discusses new findings (Piel et al. and Hinchcliffe et al.) suggesting that centrioles play a part in new checkpoints that control cell division and the ability of divided cells to replicate their DNA.
The author is in the Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA. E-mail: amurray{at}mcb.harvard.edu
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In Science Magazine
REPORTS
Edward H. Hinchcliffe, Frederick J. Miller, Matthew Cham, Alexey Khodjakov, and Greenfield Sluder (23 February 2001) Science291 (5508), 1547.
[DOI: 10.1126/science.1056866] |Abstract »|Full Text »|PDF »|Supplemental Data »
REPORTS
Matthieu Piel, Joshua Nordberg, Ursula Euteneuer, and Michel Bornens (23 February 2001) Science291 (5508), 1550.
[DOI: 10.1126/science.1057330] |Abstract »|Full Text »|PDF »|Supplemental Data »
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PARP-3 localizes preferentially to the daughter centriole and interferes with the G1/S cell cycle progression.
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