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Science 16 February 2001:
Vol. 291. no. 5507, pp. 1257 - 1260
DOI: 10.1126/science.291.5507.1257
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SEQUENCE INTERPRETATION:
Making Sense of the Sequence

David J. Galas

Although the impact of the versions of the sequence of the human genome published by Venter et al. in this issue of Science and by the publicly funded project in this week's issue of Nature will be enormous, it can be difficult to evaluate what is being represented or how to use it. Galas provides a user-friendly guide to some of the fundamental aspects of the genome sequences that have been presented. He also includes a number of tools and approaches to gene finding and gene structure that can provide access to the new data for the working biologist.

The author is at the Keck Graduate Institute of Applied Life Sciences, Claremont, CA 91711, USA. E-mail: David_Galas{at}kgi.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Activation of cryptic 3' splice sites within introns of cellular genes following gene entrapment.
A. B. Osipovich, E. K. White-Grindley, G. G. Hicks, M. J. Roshon, C. Shaffer, J. H. Moore, and H. E. Ruley (2004)
Nucleic Acids Res. 32, 2912-2924
   Abstract »    Full Text »    PDF »
Chromatin as a Tool for the Study of Genome Function in Cancer.
F. D. URNOV (2003)
Ann. N.Y. Acad. Sci. 983, 5-21
   Abstract »    Full Text »    PDF »
The mRNA of DEAD Box Protein p72 Is Alternatively Translated into an 82-kDa RNA Helicase.
H. Uhlmann-Schiffler, O. G. Rossler, and H. Stahl (2002)
J. Biol. Chem. 277, 1066-1075
   Abstract »    Full Text »    PDF »


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