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Science 2 February 2001:
Vol. 291. no. 5505, pp. 843 - 847
DOI: 10.1126/science.291.5505.843
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Review

Protein Dynamics: Implications for Nuclear Architecture and Gene Expression

Tom Misteli

Studies of nuclear architecture reveal that the dynamic properties of proteins in the nucleus are critical for their function. The high mobility of proteins ensures their availability throughout the nucleus; their dynamic interplay generates an ever-changing, but overall stable, architectural framework, within which nuclear processes take place. As a consequence, overall nuclear morphology is determined by the functional interactions of nuclear components. The observed dynamic properties of nuclear proteins are consistent with a central role for stochastic mechanisms in gene expression and nuclear architecture.

National Cancer Institute, Bethesda, MD 20892-5002, USA. E-mail: mistelit{at}mail.nih.gov

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T. H. Ward, R. S. Polishchuk, S. Caplan, K. Hirschberg, and J. Lippincott-Schwartz (2001)
J. Cell Biol. 155, 557-570
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Coilin forms the bridge between Cajal bodies and SMN, the Spinal Muscular Atrophy protein.
M. D. Hebert, P. W. Szymczyk, K. B. Shpargel, and A. G. Matera (2001)
Genes & Dev. 15, 2720-2729
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Activity-dependent nuclear translocation and intranuclear distribution of NFATc in adult skeletal muscle fibers.
Y. Liu, Z. Cseresnyes, W. R. Randall, and M. F. Schneider (2001)
J. Cell Biol. 155, 27-40
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