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Science 26 January 2001:
Vol. 291. no. 5504, pp. 661 - 664
DOI: 10.1126/science.291.5504.661
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Reports

Backward Spreading of Memory-Retrieval Signal in the Primate Temporal Cortex

Yuji Naya,1* Masatoshi Yoshida,2* Yasushi Miyashita123dagger

Bidirectional signaling between neocortex and limbic cortex has been hypothesized to contribute to the retrieval of long-term memory. We tested this hypothesis by comparing the time courses of perceptual and memory-retrieval signals in two neighboring areas in temporal cortex, area TE (TE) and perirhinal cortex (PRh), while monkeys were performing a visual pair-association task. Perceptual signal reached TE before PRh, confirming its forward propagation. In contrast, memory-retrieval signal appeared earlier in PRh, and TE neurons were then gradually recruited to represent the sought target. A reasonable interpretation of this finding is that the rich backward fiber projections from PRh to TE may underlie the activation of TE neurons that represent a visual object retrieved from long-term memory.

1 Laboratory of Cognitive Neuroscience, National Institute for Physiological Sciences, Okazaki, Aichi 444-8585, Japan.
2 Mind Articulation Project, International Cooperative Research Project (ICORP), Japan Science and Technology Corporation, Yushima, Tokyo 113-0034, Japan.
3 University of Tokyo School of Medicine, Hongo, Tokyo 113-0033, Japan.
*   These authors contributed equally to this report.

dagger    To whom correspondence should be addressed. E-mail: yasushi_miyashita{at}m.u-tokyo.ac.jp

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