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Science 22 December 2000:
Vol. 290. no. 5500, pp. 2303 - 2304
DOI: 10.1126/science.290.5500.2303
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Reports

Linkage of Plasma Abeta 42 to a Quantitative Locus on Chromosome 10 in Late-Onset Alzheimer's Disease Pedigrees

Nilufer Ertekin-Taner,1 Neill Graff-Radford,1 Linda H. Younkin,1 Christopher Eckman,1 Matthew Baker,1 Jennifer Adamson,1 James Ronald,1 John Blangero,2 Michael Hutton,1* Steven G. Younkin1

Plasma Abeta 42 (amyloid beta 42 peptide) is invariably elevated in early-onset familial Alzheimer's disease (AD), and it is also increased in the first-degree relatives of patients with typical late-onset AD (LOAD). To detect LOAD loci that increase Abeta 42, we used plasma Abeta 42 as a surrogate trait and performed linkage analysis on extended AD pedigrees identified through a LOAD patient with extremely high plasma Abeta . Here, we report linkage to chromosome 10 with a maximal lod score of 3.93 at 81 centimorgans close to D10S1225. Remarkably, linkage to the same region was obtained independently in a genome-wide screen of LOAD sibling pairs. These results provide strong evidence for a novel LOAD locus on chromosome 10 that acts to increase Abeta .

1 Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA.
2 Southwest Foundation for Biomedical Research, San Antonio, TX 78245, USA.
*   To whom correspondence should be addressed. E-mail: hutton.michael{at}mayo.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)