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Science 22 December 2000:
Vol. 290. no. 5500, pp. 2227 - 2229
DOI: 10.1126/science.290.5500.2227b
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News of the Week

CELL BIOLOGY:
Disease Genes Clarify Cholesterol Trafficking

Jean Marx

On pages 2295 and 2298, two groups report results that should help explain what goes amiss in Niemann-Pick C (NPC), a rare hereditary disease in which cholesterol so clogs cells, particularly brain cells, that the cells can't function normally and degenerate. The findings should also help solve a long-standing mystery about how cells normally handle cholesterol, and they could eventually point to new ways to treat NPC patients as well as the much larger population with elevated blood cholesterol levels.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)