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Science 8 December 2000:
Vol. 290. no. 5498, pp. 1876 - 1879
DOI: 10.1126/science.290.5498.1876
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News Focus

VIROLOGY:
Probing HIV's Elusive Activities Within the Host Cell

Marina Chicurel

Once inside a host cell, HIV must make its way to the nucleus in order to replicate, but until now, its journey has largely been uncharted territory. As researchers begin to explore this landscape a common theme is emerging: Soon after viruses enter cells, they enlist components of their hosts to assist them in their journey. Now, in what is being called one of the most exciting frontiers in AIDS research, preliminary findings on how HIV enters cell nuclei are giving AIDS researchers new leads on possible drug targets to fight the ever-mounting epidemic.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Human Polycomb Group EED Protein Interacts with the Integrase of Human Immunodeficiency Virus Type 1.
S. Violot, S. S. Hong, D. Rakotobe, C. Petit, B. Gay, K. Moreau, G. Billaud, S. Priet, J. Sire, O. Schwartz, et al. (2003)
J. Virol. 77, 12507-12522
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Science. ISSN 0036-8075 (print), 1095-9203 (online)