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TNAs [(L)--threofuranosyl oligonucleotides]
containing vicinally connected (3'2') phosphodiester bridges undergo
informationalbase pairing in antiparallel strand orientation and are
capableof cross-pairing with RNA and DNA. Being derived from a sugarcontaining only four carbons, TNA is structurally the simplestof all
potentially natural oligonucleotide-type nucleic acid alternativesstudied thus far. This, along with the base-pairing propertiesof TNA,
warrants close scrutiny of the system in the context ofthe problem of
RNA's origin.
The Skaggs Institute for Chemical Biology at The Scripps Research
Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA, and
Laboratorium für Organische Chemie, Eidgenössische
Technische Hochschule, Universitätstrasse 16, CH-8092
Zürich, Switzerland.
*
To whom correspondence should be addressed. E-mail:
aeschen{at}scripps.edu
Origin of Informational Polymers: DIFFERENTIAL STABILITY OF 3'- AND 5'-PHOSPHOESTER BONDS IN DEOXY MONOMERS AND OLIGOMERS.
R. Saladino, C. Crestini, V. Busiello, F. Ciciriello, G. Costanzo, and E. Di Mauro (2005)
J. Biol. Chem.
280, 35658-35669
|Abstract »|Full Text »|PDF »
High fidelity TNA synthesis by Therminator polymerase.
J. K. Ichida, A. Horhota, K. Zou, L. W. McLaughlin, and J. W. Szostak (2005)
Nucleic Acids Res.
33, 5219-5225
|Abstract »|Full Text »|PDF »
Catalysis and Prebiotic Synthesis.
J. P. Ferris (2005)
Reviews in Mineralogy and Geochemistry
59, 187-210
|Full Text »|PDF »
Prebiotic Amino Acids as Asymmetric Catalysts.
S. Pizzarello and A. L. Weber (2004)
Science
303, 1151
|Full Text »|PDF »
The Asymmetry of Existence: Do We Owe Our Existence to Cold Dark Matter and the Weak Force?.
A. T. Borchers, P. A. Davis, and M. E. Gershwin (2004)
Experimental Biology and Medicine
229, 21-32
|Abstract »|Full Text »|PDF »
Recognition of threosyl nucleotides by DNA and RNA polymerases.
V. Kempeneers, K. Vastmans, J. Rozenski, and P. Herdewijn (2003)
Nucleic Acids Res.
31, 6221-6226
|Abstract »|Full Text »|PDF »
-Threofuranosyl-(3'
2') Oligonucleotide System
-threofuranosyl oligonucleotides]
containing vicinally connected (3'
2') phosphodiester bridges undergo
informational base pairing in antiparallel strand orientation and are
capable of cross-pairing with RNA and DNA. Being derived from a sugar containing only four carbons, TNA is structurally the simplest of all
potentially natural oligonucleotide-type nucleic acid alternatives studied thus far. This, along with the base-pairing properties of TNA,
warrants close scrutiny of the system in the context of the problem of
RNA's origin.
