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Science 13 October 2000:
Vol. 290. no. 5490, pp. 344 - 347
DOI: 10.1126/science.290.5490.344
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Reports

Molecular Analysis of FRIGIDA, a Major Determinant of Natural Variation in Arabidopsis Flowering Time

Urban Johanson,1* Joanne West,1 Clare Lister,1 Scott Michaels,2 Richard Amasino,2 Caroline Dean1ddagger

Vernalization, the acceleration of flowering by a long period of cold temperature, ensures that many plants overwinter vegetatively and flower in spring. In Arabidopsis, allelic variation at the FRIGIDA (FRI) locus is a major determinant of natural variation in flowering time. Dominant alleles of FRI confer late flowering, which is reversed to earliness by vernalization. We cloned FRI and analyzed the molecular basis of the allelic variation. Most of the early-flowering ecotypes analyzed carry FRI alleles containing one of two different deletions that disrupt the open reading frame. Loss-of-function mutations at FRI have thus provided the basis for the evolution of many early-flowering ecotypes.

1 Department of Molecular Genetics, John Innes Centre, Norwich NR4 7UH, UK.
2 Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA.
*   Present address: Department of Plant Biochemistry, Lund University, Post Office Box 117, SE-221 00 Lund, Sweden.

ddagger    To whom correspondence should be addressed. E-mail: caroline.dean{at}bbsrc.ac.uk

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