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Rather than being confined to the secondary lymphoid
tissue of the spleen and lymph nodes, large numbers of lymphocytes areintrinsically associated with the epithelial surfaces of the body.The
best studied is gut-associated lymphoid tissue, but distinctepithelium-associated lymphoid tissue also exists in the reproductivetract, the lung, and the skin. The multiple cell types and functionscomposing these lymphoid tissues are increasingly seen as thekey to
how antigens delivered to body surfaces can elicit eitherimmunogenic
or tolerogenic responses. In some instances, theseresponses occur
purely within the local body surface tissue, yetin other cases both
local and systemic responses are elicited.
1 Peter Gorer Department of Immunobiology,
Guy's King's St Thomas' Medical School, University of London, Guy's
Hospital, London, SE1 9RT, UK.
2 Department of
Immunobiology, Immunex Corporation, Seattle, WA 98101, USA.
*
To whom correspondence should be addressed. E-mail:
adrian.hayday{at}kcl.ac.uk
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