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Science 6 October 2000:
Vol. 290. no. 5489, pp. 97 - 100
DOI: 10.1126/science.290.5489.97
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Review

The Ins and Outs of Body Surface Immunology

Adrian Hayday,1* and Joanne L. Viney2

Rather than being confined to the secondary lymphoid tissue of the spleen and lymph nodes, large numbers of lymphocytes are intrinsically associated with the epithelial surfaces of the body. The best studied is gut-associated lymphoid tissue, but distinct epithelium-associated lymphoid tissue also exists in the reproductive tract, the lung, and the skin. The multiple cell types and functions composing these lymphoid tissues are increasingly seen as the key to how antigens delivered to body surfaces can elicit either immunogenic or tolerogenic responses. In some instances, these responses occur purely within the local body surface tissue, yet in other cases both local and systemic responses are elicited.

1 Peter Gorer Department of Immunobiology, Guy's King's St Thomas' Medical School, University of London, Guy's Hospital, London, SE1 9RT, UK.
2 Department of Immunobiology, Immunex Corporation, Seattle, WA 98101, USA.
*   To whom correspondence should be addressed. E-mail: adrian.hayday{at}kcl.ac.uk

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