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Science 6 October 2000:
Vol. 290. no. 5489, pp. 89 - 92
DOI: 10.1126/science.290.5489.89
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T-Independent Immune Response: New Aspects of B Cell Biology

Sidonia Fagarasan, Tasuku Honjo*

Recent results emphasize the roles of T-independent antibody response in humoral defenses, for which B1 cells and marginal zone B cells are mostly responsible. We discuss how these cells are activated, migrate, and differentiate into antibody-producing cells in various lymphoid tissues. Based on recent findings in each of these areas of B cell biology, we propose a possible mechanism for peripheral tolerance of autoreactive B cells at target organs.

Department of Medical Chemistry, Faculty of Medicine, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan.
*   To whom correspondence should be addressed. E-mail: honjo{at}mfour.med.kyoto-u.ac.jp

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