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Science 6 October 2000:
Vol. 290. no. 5489, pp. 68 - 69
DOI: 10.1126/science.290.5489.68
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Perspectives

SIGNAL TRANSDUCTION:
Are There Close Encounters Between Signaling Pathways?

Stephane Noselli and Norbert Perrimon

Do different signaling pathways inside the same cell talk to each other? Evidence suggests that in the worm and fly, signaling pathways exist as separate linear cassettes, whereas in mammalian cells there does appear to be cross talk between signaling pathways. However, as Noselli and Perrimon argue in their Perspective, most of the evidence in mammalian cells comes from tumor cells and overexpression assays. They suggest that true cross talk may not actually exist in mammalian cells under normal circumstances.

S. Noselli is at the Institut de Recherches, UMR 65643-CNRS, Parc Valrose 06108, Nice cedex 2 France. E-mail: noselli{at}unice.fr N. Perrimon is in the Department of Genetics and the Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02215, USA. E-mail: perrimon{at}rascal.med.harvard.edu

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