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Science 29 September 2000:
Vol. 289. no. 5488, pp. 2344 - 2347
DOI: 10.1126/science.289.5488.2344
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Reports

Resetting of Circadian Time in Peripheral Tissues by Glucocorticoid Signaling

Aurélio Balsalobre,1 Steven A. Brown,1 Lysiane Marcacci,1 François Tronche,2 Christoph Kellendonk,2* Holger M. Reichardt,2 Günther Schütz,2 Ueli Schibler1dagger

In mammals, circadian oscillators reside not only in the suprachiasmatic nucleus of the brain, which harbors the central pacemaker, but also in most peripheral tissues. Here, we show that the glucocorticoid hormone analog dexamethasone induces circadian gene expression in cultured rat-1 fibroblasts and transiently changes the phase of circadian gene expression in liver, kidney, and heart. However, dexamethasone does not affect cyclic gene expression in neurons of the suprachiasmatic nucleus. This enabled us to establish an apparent phase-shift response curve specifically for peripheral clocks in intact animals. In contrast to the central clock, circadian oscillators in peripheral tissues appear to remain responsive to phase resetting throughout the day.

1 Département de Biologie Moléculaire, Sciences II, Université de Genève, 30 Quai Ernest Ansermet, CH-1211 Genève, Switzerland.
2 Molecular Biology of the Cell, Deutsches Krebsforschungzentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Federal Republic of Germany.
*   Present address: Center for Neurobiology and Behavior, 722 West 168th Street, Research Annex, New York, NY 10032, USA

dagger    To whom correspondence should be addressed. E-mail: ueli.schibler{at}molbio.unige.ch

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Y. Tong, H. Guo, J. M. Brewer, H. Lee, M. N. Lehman, and E. L. Bittman (2004)
J Biol Rhythms 19, 113-125
   Abstract »    PDF »
Influence of the Corticosterone Rhythm on Photic Entrainment of Locomotor Activity in Rats.
D. Sage, J. Ganem, F. Guillaumond, G. Laforge-Anglade, A.-M. Francois-Bellan, O. Bosler, and D. Becquet (2004)
J Biol Rhythms 19, 144-156
   Abstract »    PDF »
Diurnal Variation in Rat Liver Thyroid Hormone Receptor (TR)-{alpha} Messenger Ribonucleic Acid (mRNA) Is Dependent on the Biological Clock in the Suprachiasmatic Nucleus, whereas Diurnal Variation of TR{beta}1 mRNA Is Modified by Food Intake.
B. Z. Doulabi, M. P.-T. Schiphorst, A. Kalsbeek, E. Fliers, O. Bakker, and W. M. Wiersinga (2004)
Endocrinology 145, 1284-1289
   Abstract »    Full Text »    PDF »
Histone Acetyltransferase-dependent Chromatin Remodeling and the Vascular Clock.
A. M. Curtis, S.-b. Seo, E. J. Westgate, R. D. Rudic, E. M. Smyth, D. Chakravarti, G. A. FitzGerald, and P. McNamara (2004)
J. Biol. Chem. 279, 7091-7097
   Abstract »    Full Text »    PDF »
A Circadian Rhythm in the Expression of PERIOD2 Protein Reveals a Novel SCN-Controlled Oscillator in the Oval Nucleus of the Bed Nucleus of the Stria Terminalis.
S. Amir, E. W. Lamont, B. Robinson, and J. Stewart (2004)
J. Neurosci. 24, 781-790
   Abstract »    Full Text »    PDF »
The Suprachiasmatic Nucleus Entrains, But Does Not Sustain, Circadian Rhythmicity in the Olfactory Bulb.
D. Granados-Fuentes, L. M. Prolo, U. Abraham, and E. D. Herzog (2004)
J. Neurosci. 24, 615-619
   Abstract »    Full Text »    PDF »
The Transcriptional Repressor STRA13 Regulates a Subset of Peripheral Circadian Outputs.
A. Grechez-Cassiau, S. Panda, S. Lacoche, M. Teboul, S. Azmi, V. Laudet, J. B. Hogenesch, R. Taneja, and F. Delaunay (2004)
J. Biol. Chem. 279, 1141-1150
   Abstract »    Full Text »    PDF »
Circadian Gene Expression Regulates Pulsatile Gonadotropin-Releasing Hormone (GnRH) Secretory Patterns in the Hypothalamic GnRH-Secreting GT1-7 Cell Line.
P. E. Chappell, R. S. White, and P. L. Mellon (2003)
J. Neurosci. 23, 11202-11213
   Abstract »    Full Text »    PDF »
Molecular Mechanism of Mammalian Circadian Clock.
Y. Isojima, N. Okumura, and K. Nagai (2003)
J. Biochem. 134, 777-784
   Abstract »    Full Text »    PDF »


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