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Science 8 September 2000:
Vol. 289. no. 5485, pp. 1705 - 1706
DOI: 10.1126/science.289.5485.1705
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Perspectives

IMMUNOLOGY:
RNA Editing AIDs Antibody Diversification?

Michael S. Neuberger and James Scott

How do B cells generate the enormous diversity of antibodies that are able to recognize and bind to whichever antigen a B cell might happen to encounter in the body? Several genetic mechanisms that manipulate different combinations of immunoglobulin genes are known. In their Perspective, Neuberger and Scott, highlight another genetic mechanism called RNA editing now shown to be involved in the production of antibody diversity.

M. S. Neuberger is at the Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK. J. Scott is in the Department of Medicine, Imperial College School of Medicine, London W12 0NN, UK.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Intracellular Localization of Differentially Regulated RNA-specific Adenosine Deaminase Isoforms in Inflammation.
J.-H. Yang, Y. Nie, Q. Zhao, Y. Su, M. Pypaert, H. Su, and R. Rabinovici (2003)
J. Biol. Chem. 278, 45833-45842
   Abstract »    Full Text »    PDF »
Implications of the Human Genome for Understanding Human Biology and Medicine.
G. Subramanian, M. D. Adams, J. C. Venter, and S. Broder (2001)
JAMA 286, 2296-2307
   Abstract »    Full Text »    PDF »


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