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Science 1 September 2000:
Vol. 289. no. 5484, pp. 1567 - 1569
DOI: 10.1126/science.289.5484.1567
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Reports

Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics

Simon Melov,1 Joanne Ravenscroft,2* Sarwatt Malik,2 Matt S. Gill,2 David W. Walker,2dagger Peter E. Clayton,2 Douglas C. Wallace,3 Bernard Malfroy,4 Susan R. Doctrow,4 Gordon J. Lithgow2ddagger

We tested the theory that reactive oxygen species cause aging. We augmented the natural antioxidant systems of Caenorhabditis elegans with small synthetic superoxide dismutase/catalase mimetics. Treatment of wild-type worms increased their mean life-span by a mean of 44 percent, and treatment of prematurely aging worms resulted in normalization of their life-span (a 67 percent increase). It appears that oxidative stress is a major determinant of life-span and that it can be counteracted by pharmacological intervention.

1 Buck Institute for Age Research, Novato, CA 94949, USA.
2 The School of Biological Sciences and the Academic Unit of Child Health, The University of Manchester, Manchester, M13 9PT, UK.
3 Center for Molecular Medicine, Emory University, Atlanta, GA 30322, USA.
4 Eukarion, Bedford, MA 01730, USA.
*   Present address: Aventis Pharma, London Road, Holmes Chapel, Crewe, Cheshire, CW4 8BE, UK.

dagger    Present address: Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.

ddagger    To whom correspondence should be addressed. E-mail: Gordon.Lithgow{at}man.ac.uk

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