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Science 18 August 2000:
Vol. 289. no. 5482, pp. 1197 - 1202
DOI: 10.1126/science.289.5482.1197
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Reports

Genes Expressed in Human Tumor Endothelium

Brad St. Croix,1 Carlo Rago,12 Victor Velculescu,1 Giovanni Traverso,1 Katharine E. Romans,3 Elizabeth Montgomery,3 Anita Lal,4 Gregory J. Riggins,4 Christoph Lengauer,1 Bert Vogelstein,12 Kenneth W. Kinzler1*

To gain a molecular understanding of tumor angiogenesis, we compared gene expression patterns of endothelial cells derived from blood vessels of normal and malignant colorectal tissues. Of over 170 transcripts predominantly expressed in the endothelium, 79 were differentially expressed, including 46 that were specifically elevated in tumor-associated endothelium. Several of these genes encode extracellular matrix proteins, but most are of unknown function. Most of these tumor endothelial markers were expressed in a wide range of tumor types, as well as in normal vessels associated with wound healing and corpus luteum formation. These studies demonstrate that tumor and normal endothelium are distinct at the molecular level, a finding that may have significant implications for the development of anti-angiogenic therapies.

1 Johns Hopkins Oncology Center,
2 Howard Hughes Medical Institute,
3 Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
4 Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA.
*   To whom correspondence should be addressed. E-mail: kinzlke{at}jhmi.edu

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P. Mancuso, M. Colleoni, A. Calleri, L. Orlando, P. Maisonneuve, G. Pruneri, A. Agliano, A. Goldhirsch, Y. Shaked, R. S. Kerbel, et al. (2006)
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   Abstract »    Full Text »    PDF »
Defining the Human Macula Transcriptome and Candidate Retinal Disease Genes Using EyeSAGE.
C. Bowes Rickman, J. N. Ebright, Z. J. Zavodni, L. Yu, T. Wang, S. P. Daiger, G. Wistow, K. Boon, and M. A. Hauser (2006)
Invest. Ophthalmol. Vis. Sci. 47, 2305-2316
   Abstract »    Full Text »    PDF »
Atherosclerotic Plaque Macrophage Transcriptional Regulators Are Expressed in Blood and Modulated by Tristetraprolin.
W. D. Patino, J.-G. Kang, S. Matoba, O. Y. Mian, B. R. Gochuico, and P. M. Hwang (2006)
Circ. Res. 98, 1282-1289
   Abstract »    Full Text »    PDF »
The angiogenic function of nucleolin is mediated by vascular endothelial growth factor and nonmuscle myosin.
Y. Huang, H. Shi, H. Zhou, X. Song, S. Yuan, and Y. Luo (2006)
Blood 107, 3564-3571
   Abstract »    Full Text »    PDF »
Subtractive Transcriptomics: Establishing Polarity Drives In vitro Human Endothelial Morphogenesis..
D. A. Glesne, W. Zhang, S. Mandava, L. Ursos, M. E. Buell, L. Makowski, and D. J. Rodi (2006)
Cancer Res. 66, 4030-4040
   Abstract »    Full Text »    PDF »
The TGF{beta} activated kinase TAK1 regulates vascular development in vivo..
J. L. Jadrich, M. B. O'Connor, and E. Coucouvanis (2006)
Development 133, 1529-1541
   Abstract »    Full Text »    PDF »
Differential CD146 Expression on Circulating Versus Tissue Endothelial Cells in Rectal Cancer Patients: Implications for Circulating Endothelial and Progenitor Cells As Biomarkers for Antiangiogenic Therapy.
D. G. Duda, K. S. Cohen, E. di Tomaso, P. Au, R. J. Klein, D. T. Scadden, C. G. Willett, and R. K. Jain (2006)
J. Clin. Oncol. 24, 1449-1453
   Abstract »    Full Text »    PDF »
The Sialomucin CD34 Is a Marker of Lymphatic Endothelial Cells in Human Tumors.
U. Fiedler, S. Christian, S. Koidl, D. Kerjaschki, M. S. Emmett, D. O. Bates, G. Christofori, and H. G. Augustin (2006)
Am. J. Pathol. 168, 1045-1053
   Abstract »    Full Text »    PDF »
Tumor endothelial marker 1 (Tem1) functions in the growth and progression of abdominal tumors.
A. Nanda, B. Karim, Z. Peng, G. Liu, W. Qiu, C. Gan, B. Vogelstein, B. St. Croix, K. W. Kinzler, and D. L. Huso (2006)
PNAS 103, 3351-3356
   Abstract »    Full Text »    PDF »
Peptides selected for binding to clotted plasma accumulate in tumor stroma and wounds.
J. Pilch, D. M. Brown, M. Komatsu, T. A. H. Jarvinen, M. Yang, D. Peters, R. M. Hoffman, and E. Ruoslahti (2006)
PNAS 103, 2800-2804
   Abstract »    Full Text »    PDF »
Tensin3 is a novel thyroid-specific gene.
I. Maeda, T. Takano, H. Yoshida, F. Matsuzuka, N. Amino, and A. Miyauchi (2006)
J. Mol. Endocrinol. 36, R1-R8
   Abstract »    Full Text »    PDF »
Protein tyrosine phosphatase PRL-3 in malignant cells and endothelial cells: expression and function..
C. Rouleau, A. Roy, T. St. Martin, M. R. Dufault, P. Boutin, D. Liu, M. Zhang, K. Puorro-Radzwill, L. Rulli, D. Reczek, et al. (2006)
Mol. Cancer Ther. 5, 219-229
   Abstract »    Full Text »    PDF »
Angiostatic activity of DNA methyltransferase inhibitors..
D. M.E.I. Hellebrekers, K.-W. Jair, E. Vire, S. Eguchi, N. T.H. Hoebers, M. F. Fraga, M. Esteller, F. Fuks, S. B. Baylin, M. van Engeland, et al. (2006)
Mol. Cancer Ther. 5, 467-475
   Abstract »    Full Text »    PDF »
Expression of Pax2 in Human Renal Tumor-Derived Endothelial Cells Sustains Apoptosis Resistance and Angiogenesis.
V. Fonsato, S. Buttiglieri, M. C. Deregibus, V. Puntorieri, B. Bussolati, and G. Camussi (2006)
Am. J. Pathol. 168, 706-713
   Abstract »    Full Text »    PDF »
Screening phage display libraries for organ-specific vascular immunotargeting in vivo.
P. Valadon, J. D. Garnett, J. E. Testa, M. Bauerle, P. Oh, and J. E. Schnitzer (2006)
PNAS 103, 407-412
   Abstract »    Full Text »    PDF »
Molecular Fingerprinting and Autocrine Growth Regulation of Endothelial Cells in a Murine Model of Hepatocellular Carcinoma.
E. Ryschich, P. Lizdenis, C. Ittrich, A. Benner, S. Stahl, A. Hamann, J. Schmidt, P. Knolle, B. Arnold, G. J. Hammerling, et al. (2006)
Cancer Res. 66, 198-211
   Abstract »    Full Text »    PDF »
Antitumor efficacy of a urokinase activation-dependent anthrax toxin.
B. Rono, J. Romer, S. Liu, T. H. Bugge, S. H. Leppla, and P. E.G. Kristjansen (2006)
Mol. Cancer Ther. 5, 89-96
   Abstract »    Full Text »    PDF »


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