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Science 18 August 2000: Vol. 289. no. 5482, pp. 1197 - 1202 DOI: 10.1126/science.289.5482.1197
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Reports
Genes Expressed in Human Tumor Endothelium
Brad St. Croix,1
Carlo Rago,12
Victor Velculescu,1
Giovanni Traverso,1
Katharine E. Romans,3
Elizabeth Montgomery,3
Anita Lal,4
Gregory
J. Riggins,4
Christoph Lengauer,1
Bert Vogelstein,12
Kenneth W. Kinzler1*
To gain a molecular understanding of tumor angiogenesis, we
compared gene expression patterns of endothelial cells derived from
blood vessels of normal and malignant colorectal tissues. Of over 170 transcripts predominantly expressed in the endothelium, 79 were
differentially expressed, including 46 that were specifically elevated
in tumor-associated endothelium. Several of these genes encode
extracellular matrix proteins, but most are of unknown function. Most
of these tumor endothelial markers were expressed in a wide range of
tumor types, as well as in normal vessels associated with wound healing
and corpus luteum formation. These studies demonstrate that tumor and
normal endothelium are distinct at the molecular level, a finding that
may have significant implications for the development of
anti-angiogenic therapies.
1 Johns Hopkins Oncology Center,
2 Howard Hughes Medical Institute,
3 Department of Pathology, Johns Hopkins University
School of Medicine, Baltimore, MD 21231, USA.
4 Department of Pathology, Duke University Medical
Center, Durham, NC 27710, USA.
*
To whom correspondence should be addressed. E-mail:
kinzlke{at}jhmi.edu
Read the Full Text
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Physiol Genomics
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Diabetes
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- Circulating endothelial-cell kinetics and viability predict survival in breast cancer patients receiving metronomic chemotherapy.
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- Atherosclerotic Plaque Macrophage Transcriptional Regulators Are Expressed in Blood and Modulated by Tristetraprolin.
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Blood
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Development
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