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Brad St. Croix,1Carlo Rago,12Victor Velculescu,1Giovanni Traverso,1Katharine E. Romans,3Elizabeth Montgomery,3Anita Lal,4Gregory
J. Riggins,4Christoph Lengauer,1Bert Vogelstein,12Kenneth W. Kinzler1*
To gain a molecular understanding of tumor angiogenesis, we
compared gene expression patterns of endothelial cells derivedfrom
blood vessels of normal and malignant colorectal tissues.Of over 170 transcripts predominantly expressed in the endothelium,79 were
differentially expressed, including 46 that were specificallyelevated
in tumor-associated endothelium. Several of these genesencode
extracellular matrix proteins, but most are of unknownfunction. Most
of these tumor endothelial markers were expressedin a wide range of
tumor types, as well as in normal vessels associatedwith wound healing
and corpus luteum formation. These studiesdemonstrate that tumor and
normal endothelium are distinct atthe molecular level, a finding that
may have significant implicationsfor the development of
anti-angiogenic therapies.
1 Johns Hopkins Oncology Center,
2 Howard Hughes Medical Institute,
3 Department of Pathology, Johns Hopkins University
School of Medicine, Baltimore, MD 21231, USA.
4 Department of Pathology, Duke University Medical
Center, Durham, NC 27710, USA.
*
To whom correspondence should be addressed. E-mail:
kinzlke{at}jhmi.edu
The editors suggest the following Related Resources on Science sites:
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[DOI: 10.1126/science.289.5482.1121a] |Summary »|Full Text »
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|Abstract »|Full Text »|PDF »
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J. Biol. Chem.
281, 27621-27632
|Abstract »|Full Text »|PDF »
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|Abstract »|Full Text »|PDF »
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J. Biol. Chem.
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24, 1449-1453
|Abstract »|Full Text »|PDF »
The Sialomucin CD34 Is a Marker of Lymphatic Endothelial Cells in Human Tumors.
U. Fiedler, S. Christian, S. Koidl, D. Kerjaschki, M. S. Emmett, D. O. Bates, G. Christofori, and H. G. Augustin (2006)
Am. J. Pathol.
168, 1045-1053
|Abstract »|Full Text »|PDF »
Tumor endothelial marker 1 (Tem1) functions in the growth and progression of abdominal tumors.
A. Nanda, B. Karim, Z. Peng, G. Liu, W. Qiu, C. Gan, B. Vogelstein, B. St. Croix, K. W. Kinzler, and D. L. Huso (2006)
PNAS
103, 3351-3356
|Abstract »|Full Text »|PDF »
Peptides selected for binding to clotted plasma accumulate in tumor stroma and wounds.
J. Pilch, D. M. Brown, M. Komatsu, T. A. H. Jarvinen, M. Yang, D. Peters, R. M. Hoffman, and E. Ruoslahti (2006)
PNAS
103, 2800-2804
|Abstract »|Full Text »|PDF »
Tensin3 is a novel thyroid-specific gene.
I. Maeda, T. Takano, H. Yoshida, F. Matsuzuka, N. Amino, and A. Miyauchi (2006)
J. Mol. Endocrinol.
36, R1-R8
|Abstract »|Full Text »|PDF »
Protein tyrosine phosphatase PRL-3 in malignant cells and endothelial cells: expression and function..
C. Rouleau, A. Roy, T. St. Martin, M. R. Dufault, P. Boutin, D. Liu, M. Zhang, K. Puorro-Radzwill, L. Rulli, D. Reczek, et al. (2006)
Mol. Cancer Ther.
5, 219-229
|Abstract »|Full Text »|PDF »
Angiostatic activity of DNA methyltransferase inhibitors..
D. M.E.I. Hellebrekers, K.-W. Jair, E. Vire, S. Eguchi, N. T.H. Hoebers, M. F. Fraga, M. Esteller, F. Fuks, S. B. Baylin, M. van Engeland, et al. (2006)
Mol. Cancer Ther.
5, 467-475
|Abstract »|Full Text »|PDF »
Expression of Pax2 in Human Renal Tumor-Derived Endothelial Cells Sustains Apoptosis Resistance and Angiogenesis.
V. Fonsato, S. Buttiglieri, M. C. Deregibus, V. Puntorieri, B. Bussolati, and G. Camussi (2006)
Am. J. Pathol.
168, 706-713
|Abstract »|Full Text »|PDF »
Screening phage display libraries for organ-specific vascular immunotargeting in vivo.
P. Valadon, J. D. Garnett, J. E. Testa, M. Bauerle, P. Oh, and J. E. Schnitzer (2006)
PNAS
103, 407-412
|Abstract »|Full Text »|PDF »
Molecular Fingerprinting and Autocrine Growth Regulation of Endothelial Cells in a Murine Model of Hepatocellular Carcinoma.
E. Ryschich, P. Lizdenis, C. Ittrich, A. Benner, S. Stahl, A. Hamann, J. Schmidt, P. Knolle, B. Arnold, G. J. Hammerling, et al. (2006)
Cancer Res.
66, 198-211
|Abstract »|Full Text »|PDF »
Antitumor efficacy of a urokinase activation-dependent anthrax toxin.
B. Rono, J. Romer, S. Liu, T. H. Bugge, S. H. Leppla, and P. E.G. Kristjansen (2006)
Mol. Cancer Ther.
5, 89-96
|Abstract »|Full Text »|PDF »
