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Retraction of Tracy et al., Science 288 (5468) 1058-1061.

Science 18 August 2000:
Vol. 289. no. 5482, p. 1141
DOI: 10.1126/science.289.5482.1141b
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Letters

Retraction

In the course of carrying out experiments that were a direct extension of our recent Science paper "Stable RNA/DNA hybrids in the mammalian genome: inducible intermediates in immunoglobulin class switch recombination" (1), we discovered differences from those in the paper. The first author (R. B. Tracy) has admitted to data alteration such that the primary conclusions of the paper are in question. Because of this, the authors are retracting the entire paper on class switch recombination (1). We are deeply regretful for any scientific misconceptions that have resulted from these studies. [Note that the following related paper is also being retracted for the same reason: R. B. Tracy and M. R. Lieber, "Transcription-dependent R-loop formation at mammalian class switch sequences," EMBO J. 19, 1055 (2000).]

Robert B. Tracy1

Chih-Lin Hsieh2, 3

Michael R. Lieber1, 2, 4, 5

1Department of Pathology

2Department of Biochemistry and Molecular Biology

3Department of Urology

4Department of Microbiology

5Department of Biology,
University of Southern California Keck School of Medicine,
Norris Comprehensive Cancer Center,
Rooms 5420 and 5428,
Los Angeles, CA 90089-9176, USA.
E-mail: lieber{at}hsc.usc.edu

Reference
  1. R. B. Tracy, C.-L. Hsieh, M. R. Lieber, Science 288, 1058 (2000).




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