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Science 11 August 2000:
Vol. 289. no. 5481, pp. 883 - 884
DOI: 10.1126/science.289.5481.883
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Perspectives

IMMUNOLOGY:
Lymphocyte Survival--Ignorance Is BLys

Yacine Laâbi and Andreas Strasser

As if the TNF receptor and ligand superfamily was not big enough, two new receptors and their ligands have now been added to it. As Laâbi and Strasser explain in their Perspective, the receptors BCMA and TACI and their ligands BAFF/BLys and APRIL, respectively, are important for B lymphocyte survival, proliferation, and differentiation.

The authors are at the Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, 3050 Victoria, Australia. E-mail: laabi{at}wehi.edu.au; strasser{at}wehi.edu.au

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A Role for B Cell-Activating Factor of the TNF Family in Chemically Induced Autoimmunity.
Y. Zheng, S. Gallucci, J. P. Gaughan, J. A. Gross, and M. Monestier (2005)
J. Immunol. 175, 6163-6168
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CD9 Is a Unique Marker for Marginal Zone B Cells, B1 Cells, and Plasma Cells in Mice.
W.-J. Won and J. F. Kearney (2002)
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B-Cell Maturation Protein, Which Binds the Tumor Necrosis Factor Family Members BAFF and APRIL, Is Dispensable for Humoral Immune Responses.
S. Xu and K.-P. Lam (2001)
Mol. Cell. Biol. 21, 4067-4074
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Tolerance and Autoimmunity.
T. Kamradt and N. A. Mitchison (2001)
N. Engl. J. Med. 344, 655-664
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