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Science 28 July 2000:
Vol. 289. no. 5479, pp. 617 - 619
DOI: 10.1126/science.289.5479.617
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Reports

Dependence of Stem Cell Fate in Arabidopsis on a Feedback Loop Regulated by CLV3 Activity

Ulrike Brand,1 Jennifer C. Fletcher,2* Martin Hobe,1 Elliot M. Meyerowitz,2 Rüdiger Simon1dagger

The fate of stem cells in plant meristems is governed by directional signaling systems that are regulated by negative feedback. In Arabidopsis thaliana, the CLAVATA (CLV) genes encode the essential components of a negative, stem cell-restricting pathway. We used transgenic plants overexpressing CLV3 to show that meristem cell accumulation and fate depends directly on the level of CLV3 activity and that CLV3 signaling occurs exclusively through a CLV1/CLV2 receptor kinase complex. We also demonstrate that the CLV pathway acts by repressing the activity of the transcription factor WUSCHEL, an element of the positive, stem cell-promoting pathway.

1 Institut für Entwicklungsbiologie, Universität zu Köln, Gyrhofstrabeta e 17, D-50923 Köln, Germany.
2 Division of Biology 156-29, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA.
*   Present address: U.S. Department of Agriculture Plant Gene Expression Center, University of California Berkeley, Department of Plant and Microbial Biology, 800 Buchanan Street, Albany, CA 94710, USA.

dagger    To whom correspondence should be addressed. E-mail: ruediger.simon{at}uni-koeln.de

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The Maize CRINKLY4 Receptor Kinase Controls a Cell-Autonomous Differentiation Response.
P. W. Becraft, S.-H. Kang, and S.-G. Suh (2001)
Plant Physiology 127, 486-496
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Receptor-like kinases from Arabidopsis form a monophyletic gene family related to animal receptor kinases.
S.-H. Shiu and A. B. Bleecker (2001)
PNAS
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Science. ISSN 0036-8075 (print), 1095-9203 (online)