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Science 14 July 2000:
Vol. 289. no. 5477, pp. 232 - 235
DOI: 10.1126/science.289.5477.232

News Focus

MOLECULAR BIOLOGY:
Creation's Seventh Day

Robert F. Service

Scientists at the Scripps Research Institute are attempting to find out what life would look like if DNA contained more than four nucleotide bases and proteins more than 20 amino acids. By reengineering DNA, RNA, and the proteins that interact with them, they hope to create synthetic organisms with a chemical makeup fundamentally different from all life that has existed on Earth for the last 3.8 billion years. If they succeed, their biochemical reengineering could have a profound effect on everything from basic molecular biology to industrial chemistry.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
PCR amplification of DNA containing non-standard base pairs by variants of reverse transcriptase from Human Immunodeficiency Virus-1.
A. M. Sismour, S. Lutz, J.-H. Park, M. J. Lutz, P. L. Boyer, S. H. Hughes, and S. A. Benner (2004)
Nucleic Acids Res. 32, 728-735
   Abstract »    Full Text »    PDF »
Decoding of tandem quadruplets by adjacent tRNAs with eight-base anticodon loops.
B. Moore, C. C. Nelson, B. C. Persson, R. F. Gesteland, and J. F. Atkins (2000)
Nucleic Acids Res. 28, 3615-3624
   Abstract »    Full Text »    PDF »



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Science. ISSN 0036-8075 (print), 1095-9203 (online)