Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
American Society for Biochemistry and Molecular Biology

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 7 July 2000:
Vol. 289. no. 5476, pp. 73 - 74
DOI: 10.1126/science.289.5476.73
Prev | Table of Contents | Next

Perspectives

MOLECULAR BIOLOGY:
Transposase Team Puts a Headlock on DNA

Tanya L. Williams and Tania A. Baker

Transposable DNA elements jump from one location in the genome to another. But, the cut-and-paste molecular machinations that support this nomadic lifestyle are still being unraveled. In their Perspective, Williams and Baker at the Massachusetts Institute of Technology discuss new details of transposon relocation revealed through resolution of the structure of a transposase enzyme bound to DNA (Davies et al.).

T. L. Williams is in the Department of Chemistry, Office 68-517, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. E-mail: tlwillia{at}mit.edu T. A. Baker is in the Department of Biology, Building 68, Room 523, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. E-mail: tabaker{at}mit.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Structural Organization of Avian Retrovirus Integrase in Assembled Intasomes Mediating Full-site Integration.
A. Vora, S. Bera, and D. Grandgenett (2004)
J. Biol. Chem. 279, 18670-18678
   Abstract »    Full Text »    PDF »
DNase Protection Analysis of Retrovirus Integrase at the Viral DNA Ends for Full-Site Integration In Vitro.
A. Vora and D. P. Grandgenett (2001)
J. Virol. 75, 3556-3567
   Abstract »    Full Text »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)