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Science 9 June 2000:
Vol. 288. no. 5472, pp. 1759 - 1760
DOI: 10.1126/science.288.5472.1759
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Perspectives

DEVELOPMENT:
PARallels in Axis Formation

Jason Morris, Ruth Lehmann, Caryn Navarro

There is an intricate network of molecules called cell fate determinants that instruct the cells of the embryo to take on either an anterior or posterior fate. In a lively Perspective, Lehmann and her colleagues discuss new findings in the fruit fly that identify a key protein, PAR-1, which ensures that the cell fate determinants are themselves located in the correct region of the oocyte. In this way, the anterior-posterior axis is set up in the fruit fly egg before fertilization.

The authors are in the Developmental Genetics Program, Skirball Institute, Howard Hughes Medical Institute, Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA. E-mail: lehmann{at}saturn.med.nyu.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
OMA-1 is a P granules-associated protein that is required for germline specification in Caenorhabditis elegans embryos.
M. Shimada, H. Yokosawa, and H. Kawahara (2006)
Genes Cells 11, 383-396
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Science. ISSN 0036-8075 (print), 1095-9203 (online)