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Science 9 June 2000:
Vol. 288. no. 5472, pp. 1757 - 1759
DOI: 10.1126/science.288.5472.1757
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Perspectives

AIDS:
Origins of HIV

David M. Hillis

Establishing the date when immunodeficiency viruses were transmitted from nonhuman primates to humans should provide a clue to the origin of the AIDS pandemic. In his Perspective, Hillis discusses an important analysis of the molecular divergence of SIV and HIV genes (Korber et al.). This analysis establishes 1931 as the date of origin of the HIV-1 M-group viruses (the principal cause of the AIDS pandemic). Hillis discusses three possible hypotheses of immunodeficiency virus transmission that are consistent with this date.

The author is in the Section of Integrative Biology and the Institute for Cellular and Molecular Biology, School of Biological Sciences, University of Texas, Austin, TX 78712, USA. E-mail: dhillis{at}mail.utexas.edu

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E-Letters:

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Chimpanzee Kidneys Not Used to Prepare Oral Poliovirus Vaccines
Robert F. Garry
Science Online, 19 Jun 2000 [Full text]
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Science Online, 19 Jun 2000 [Full text]
If OPV Were the Source of AIDS
Horia Georgescu
Science Online, 13 Nov 2000 [Full text]

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