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Science 31 March 2000:
Vol. 287. no. 5462, pp. 2435 - 2436
DOI: 10.1126/science.287.5462.2435
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Perspectives

STRUCTURAL BIOLOGY:
Bit Players in the Trombone Orchestra

Peter H. von Hippel and Debra H. Jing

The semiconservative replication of DNA dictates that the leading and lagging DNA template strands are reproduced simultaneously by a pair of DNA polymerases that travel along the replication fork in opposite directions. The complex molecular machinery that is responsible for seamless DNA synthesis is only now becoming understood, in large part due to the resolution of the structures of the various molecular players. In a Perspective, von Hippel and Jing discuss new findings (Keck et al.) that reveal the inner workings of one of the many components of this molecular machinery, the DNA primase.

The authors are at the Molecular Biology Institute, University of Oregon, Eugene, OR 97403, USA. E-mail: petevh{at}molbio.uoregon.edu, jing{at}molbio.uoregon.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)