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Science 24 March 2000:
Vol. 287. no. 5461, pp. 2182 - 2184
DOI: 10.1126/science.287.5461.2182
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Ideas Fly at Gene-Finding Jamboree

Elizabeth Pennisi

Sequencing and assembly are just the first steps to completing a genome; the tough task is to pinpoint the genes and begin to figure out what they do, a process called "annotation" in the jargon of genomics. So late last fall, once the sequencing and assembly of the genome of the fruit fly Drosophila melanogaster was completed, computer experts and fruit fly geneticists came together at an unusual jamboree to make sense of it. By all accounts, this slam-dunk approach, which took 11 days, worked even better than expected. The results of this effort were announced in February and are published in the series of papers in this special issue.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A Community-Based Annotation Framework for Linking Solanaceae Genomes with Phenomes.
N. Menda, R. M. Buels, I. Tecle, and L. A. Mueller (2008)
Plant Physiology 147, 1788-1799
   Abstract »    Full Text »    PDF »
Pirk Is a Negative Regulator of the Drosophila Imd Pathway.
A. Kleino, H. Myllymaki, J. Kallio, L.-M. Vanha-aho, K. Oksanen, J. Ulvila, D. Hultmark, S. Valanne, and M. Ramet (2008)
J. Immunol. 180, 5413-5422
   Abstract »    Full Text »    PDF »
Community annotation: Procedures, protocols, and supporting tools.
C. G. Elsik, K. C. Worley, L. Zhang, N. V. Milshina, H. Jiang, J. T. Reese, K. L. Childs, A. Venkatraman, C. M. Dickens, G. M. Weinstock, et al. (2006)
Genome Res. 16, 1329-1333
   Abstract »    Full Text »    PDF »
Genome annotation past, present, and future: How to define an ORF at each locus.
M. R. Brent (2005)
Genome Res. 15, 1777-1786
   Abstract »    Full Text »    PDF »
Nuclear DNA Amounts in Angiosperms: Progress, Problems and Prospects.
M. D. BENNETT and I. J. LEITCH (2005)
Ann. Bot. 95, 45-90
   Abstract »    Full Text »    PDF »
Pseudomonas aeruginosa Genome Database and PseudoCAP: facilitating community-based, continually updated, genome annotation.
G. L. Winsor, R. Lo, S. J. H. Sui, K. S.E. Ung, S. Huang, D. Cheng, W.-K. H. Ching, R. E. W. Hancock, and F. S. L. Brinkman (2005)
Nucleic Acids Res. 33, D338-D343
   Abstract »    Full Text »    PDF »
A Guide to the Mammalian Genome.
Y. Okazaki and D. A. Hume (2003)
Genome Res. 13, 1267-1272
   Full Text »    PDF »
The Draft Genome of Ciona intestinalis: Insights into Chordate and Vertebrate Origins.
P. Dehal, Y. Satou, R. K. Campbell, J. Chapman, B. Degnan, A. De Tomaso, B. Davidson, A. Di Gregorio, M. Gelpke, D. M. Goodstein, et al. (2002)
Science 298, 2157-2167
   Abstract »    Full Text »    PDF »
A family of peptidoglycan recognition proteins in the fruit fly Drosophila melanogaster.
T. Werner, G. Liu, D. Kang, S. Ekengren, H. Steiner, and D. Hultmark (2000)
PNAS 97, 13772-13777
   Abstract »    Full Text »    PDF »


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