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Science 10 March 2000:
Vol. 287. no. 5459, pp. 1738 - 1741
DOI: 10.1126/science.287.5459.1738
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OBESITY RESEARCH:
Tracing Leptin's Partners in Regulating Body Weight

Trisha Gura

Although the hormone leptin hasn't turned out to be a "magic bullet" for obesity, its discovery has stimulated basic lab research which has been sketching out a much clearer picture of just how the body controls its weight. Researchers have identified a wealth of molecules involved in weight regulation, some of which cooperate with leptin to suppress appetite, while others blunt the hormone's fat-busting effects. Combining all these new molecular actors together in one leptin-conducted performance will be a daunting task, but they are already providing new targets for antiobesity drugs.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Modulation of 11{beta}-Hydroxysteroid Dehydrogenase Type 1 in Mature Human Subcutaneous Adipocytes by Hypothalamic Messengers.
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Molecular-Based Therapeutic Approaches in Treatment of Anorexia of Aging and Cancer Cachexia.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)