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Science 25 February 2000:
Vol. 287. no. 5457, pp. 1421 - 1422
DOI: 10.1126/science.287.5457.1421
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News

Fetal Neuron Grafts Pave the Way for Stem Cell Therapies

Marcia Barinaga

Over the past 10 years, researchers have learned that fetal nerve cell transplants can alleviate the symptoms of Parkinson's disease. But despite the promise these cells have shown, they will never be widely used, for reasons ranging from ethical concerns to the fact that there will simply never be enough fetal tissue to treat the 1 million Parkinson's patients in the United States alone. The hope now is that stem cells can be used instead. To do so, however, researchers must first learn how to keep stem cells dividing for many generations in culture and then be able to trigger them to differentiate into the type of neuron they want, as it may be crucial to use the specific type of dopamine neurons that die in Parkinson's.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Intracerebral peripheral blood stem cell (CD34+) implantation induces neuroplasticity by enhancing beta1 integrin-mediated angiogenesis in chronic stroke rats..
W.-C. Shyu, S.-Z. Lin, M.-F. Chiang, C.-Y. Su, and H. Li (2006)
J. Neurosci. 26, 3444-3453
   Abstract »    Full Text »    PDF »
Treatment of stroke in rat with intracarotid administration of marrow stromal cells.
Y. Li, J. Chen, L. Wang, M. Lu, and M. Chopp (2001)
Neurology 56, 1666-1672
   Abstract »    Full Text »    PDF »
An algorithm (decision tree) for the management of Parkinson's disease (2001):: Treatment.
C. W. Olanow, R. L. Watts, and W. C. Koller (2001)
Neurology 56, S1-S88
   Full Text »    PDF »
Prospects for Neurology and Psychiatry.
W. M. Cowan and E. R. Kandel (2001)
JAMA 285, 594-600
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)