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Science 11 February 2000:
Vol. 287. no. 5455, p. 933
DOI: 10.1126/science.287.5455.933h
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One subunit of the receptor for the cytokine interleukin-6 (IL-6) is gp130. Tyrosine phosphorylation of gp130 recruits both protein phosphatase 2 (SHP2) and signal transducer and activator 3 (STAT3). Ohtani et al. utilized knock-in technology to create mice deficient in only the gp130-mediated SHP2 pathway or the gp130-mediated STAT3 pathway to identify the functions of these two pathways. STAT3 signaling was required for embryonic development, whereas SHP2 signaling-deficient mice were viable and fertile. Reciprocal roles for signaling via STAT3 (positive) and SHP2 (negative) were found for cytokine production in T cells and immunoglobulin responses in B cells, consistent with the observation that eliminating the SHP2 pathway resulted in prolonged IL-6-induced STAT3 phosphorylation. -- NG

Immunity 12, 95 (2000).

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Science. ISSN 0036-8075 (print), 1095-9203 (online)