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Science 4 February 2000:
Vol. 287. no. 5454, pp. 845 - 848
DOI: 10.1126/science.287.5454.845
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Reports

Cross-Species Interactions Between Malaria Parasites in Humans

Marian C. Bruce, 1* Christl A. Donnelly, 1 Michael P. Alpers, 2 Mary R. Galinski, 3 John W. Barnwell, 4 David Walliker, 5 Karen P. Day 1

The dynamics of multiple Plasmodium infections in asymptomatic children living under intense malaria transmission pressure provide evidence for a density-dependent regulation that transcends species as well as genotype. This regulation, in combination with species- and genotype-specific immune responses, results in nonindependent, sequential episodes of infection with each species.

1 Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, Oxford, OX1 3FY, UK.
2 Papua New Guinea Institute of Medical Research, Post Office Box 378, Madang, Papua New Guinea.
3 Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Emory Vaccine Center at Yerkes, Atlanta, GA 30329, USA.
4 Biology and Diagnostic Branch, Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA.
5 Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh, EH9 3JN, UK.
*   To whom correspondence should be addressed. E-mail: marian.bruce{at}ceid.ox.ac.uk

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