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Science 24 December 1999:
Vol. 286. no. 5449, pp. 2517 - 2520
DOI: 10.1126/science.286.5449.2517
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Reports

Bacteriophytochromes: Phytochrome-Like Photoreceptors from Nonphotosynthetic Eubacteria

Seth J. Davis, 1 Alexander V. Vener, 2 Richard D. Vierstra 12*

Phytochromes are a family of photoreceptors used by green plants to entrain their development to the light environment. The distribution of these chromoproteins has been expanded beyond photoautotrophs with the discovery of phytochrome-like proteins in the nonphotosynthetic eubacteria Deinococcus radiodurans and Pseudomonas aeruginosa. Like plant phytochromes, the D. radiodurans receptor covalently binds linear tetrapyrroles autocatalytically to generate a photochromic holoprotein. However, the attachment site is distinct, using a histidine to potentially form a Schiff base linkage. Sequence homology and mutational analysis suggest that D. radiodurans bacteriophytochrome functions as a light-regulated histidine kinase, which helps protect the bacterium from visible light.

1 Laboratory of Genetics,
2 Cellular and Molecular Biology Program and Department of Horticulture, University of Wisconsin-Madison, 1575 Linden Drive, Madison, WI 53706, USA.
*   To whom correspondence should be addressed. E-mail: vierstra{at}facstaff.wisc.edu

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