Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 24 December 1999:
Vol. 286. no. 5449, pp. 2514 - 2517
DOI: 10.1126/science.286.5449.2514
Prev | Table of Contents | Next

Reports

Reduced MAP Kinase Phosphatase-1 Degradation After p42/p44MAPK-Dependent Phosphorylation

Jean-Marc Brondello, * Jacques Pouysségur, Fergus R. McKenzie dagger

The mitogen-activated protein (MAP) kinase cascade is inactivated at the level of MAP kinase by members of the MAP kinase phosphatase (MKP) family, including MKP-1. MKP-1 was a labile protein in CCL39 hamster fibroblasts; its degradation was attenuated by inhibitors of the ubiquitin-directed proteasome complex. MKP-1 was a target in vivo and in vitro for p42MAPK or p44MAPK, which phosphorylates MKP-1 on two carboxyl-terminal serine residues, Serine 359 and Serine 364. This phosphorylation did not modify MKP-1's intrinsic ability to dephosphorylate p44MAPK but led to stabilization of the protein. These results illustrate the importance of regulated protein degradation in the control of mitogenic signaling.

Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, Centre A. Lacassagne, 33 Avenue de Valombrose, Nice 06189, France.
*   Present address: The Scripps Research Institute, Department of Molecular Biology, MB-3, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

dagger    To whom correspondence should be addressed. E-mail: mckenzie{at}unice.fr

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
KLF5 Promotes Breast Cell Survival Partially through Fibroblast Growth Factor-binding Protein 1-pERK-mediated Dual Specificity MKP-1 Protein Phosphorylation and Stabilization.
R. Liu, H.-Q. Zheng, Z. Zhou, J.-T. Dong, and C. Chen (2009)
J. Biol. Chem. 284, 16791-16798
   Abstract »    Full Text »    PDF »
Glutamine Protects Mice from Lethal Endotoxic Shock via a Rapid Induction of MAPK Phosphatase-1.
H.-M. Ko, S.-H. Oh, H.-S. Bang, N.-I. Kang, B.-H. Cho, S.-Y. Im, and H.-K. Lee (2009)
J. Immunol. 182, 7957-7962
   Abstract »    Full Text »    PDF »
Mitogen-Activated Protein Kinase Phosphatase-1 in Human Breast Cancer Independently Predicts Prognosis and Is Repressed by Doxorubicin.
F. Rojo, I. Gonzalez-Navarrete, R. Bragado, A. Dalmases, S. Menendez, M. Cortes-Sempere, C. Suarez, C. Oliva, S. Servitja, V. Rodriguez-Fanjul, et al. (2009)
Clin. Cancer Res. 15, 3530-3539
   Abstract »    Full Text »    PDF »
Atrogin-1/MAFbx Enhances Simulated Ischemia/Reperfusion-induced Apoptosis in Cardiomyocytes through Degradation of MAPK Phosphatase-1 and Sustained JNK Activation.
P. Xie, S. Guo, Y. Fan, H. Zhang, D. Gu, and H. Li (2009)
J. Biol. Chem. 284, 5488-5496
   Abstract »    Full Text »    PDF »
Negative and Positive Regulation of MAPK Phosphatase 3 Controls Platelet-derived Growth Factor-induced Erk Activation.
A. Jurek, K. Amagasaki, A. Gembarska, C.-H. Heldin, and J. Lennartsson (2009)
J. Biol. Chem. 284, 4626-4634
   Abstract »    Full Text »    PDF »
Cocaine- and Amphetamine-Regulated Transcript Accelerates Termination of Follicle-Stimulating Hormone-Induced Extracellularly Regulated Kinase 1/2 and Akt Activation by Regulating the Expression and Degradation of Specific Mitogen-Activated Protein Kinase Phosphatases in Bovine Granulosa Cells.
A. Sen, L. Lv, N. Bello, J. J. Ireland, and G. W. Smith (2008)
Mol. Endocrinol. 22, 2655-2676
   Abstract »    Full Text »    PDF »
Thyroid Hormone-Mediated Activation of the ERK/Dual Specificity Phosphatase 1 Pathway Augments the Apoptosis of GH4C1 Cells by Down-Regulating Nuclear Factor-{kappa}B Activity.
A. Chiloeches, A. Sanchez-Pacheco, B. Gil-Araujo, A. Aranda, and M. Lasa (2008)
Mol. Endocrinol. 22, 2466-2480
   Abstract »    Full Text »    PDF »
Cellular distributions of molecules with altered expression specific to the tumor promotion process from the early stage in a rat two-stage hepatocarcinogenesis model.
M. Takahashi, M. Shibutani, G.-H. Woo, K. Inoue, H. Fujimoto, K. Igarashi, J. Kanno, M. Hirose, and A. Nishikawa (2008)
Carcinogenesis 29, 2218-2226
   Abstract »    Full Text »    PDF »
Acetylation of MKP-1 and the Control of Inflammation.
H. Chi and R. A. Flavell (2008)
Science Signaling 1, pe44
   Abstract »    Full Text »    PDF »
Stimulation of N-Terminal Truncated Isoform of Androgen Receptor Stabilizes Human Ether-a-go-go-Related Gene-Encoded Potassium Channel Protein via Activation of Extracellular Signal Regulated Kinase 1/2.
Z.-Y. Wu, K. Chen, B. Haendler, T. V. McDonald, and J.-S. Bian (2008)
Endocrinology 149, 5061-5069
   Abstract »    Full Text »    PDF »
Mitogen-Activated Protein (MAP) Kinase/MAP Kinase Phosphatase Regulation: Roles in Cell Growth, Death, and Cancer.
T. Boutros, E. Chevet, and P. Metrakos (2008)
Pharmacol. Rev. 60, 261-310
   Abstract »    Full Text »    PDF »
Nitroalkenes Suppress Lipopolysaccharide-Induced Signal Transducer and Activator of Transcription Signaling in Macrophages: A Critical Role of Mitogen-Activated Protein Kinase Phosphatase 1.
T. Ichikawa, J. Zhang, K. Chen, Y. Liu, F. J. Schopfer, P. R. S. Baker, B. A. Freeman, Y. E. Chen, and T. Cui (2008)
Endocrinology 149, 4086-4094
   Abstract »    Full Text »    PDF »
Mitogen-activated Protein Kinase Phosphatase-1 Represses c-Jun NH2-terminal Kinase-mediated Apoptosis via NF-{kappa}B Regulation.
Z. Wang, N. Cao, D. Nantajit, M. Fan, Y. Liu, and J. J. Li (2008)
J. Biol. Chem. 283, 21011-21023
   Abstract »    Full Text »    PDF »
MKP-1 mRNA Stabilization and Translational Control by RNA-Binding Proteins HuR and NF90.
Y. Kuwano, H. H. Kim, K. Abdelmohsen, R. Pullmann Jr., J. L. Martindale, X. Yang, and M. Gorospe (2008)
Mol. Cell. Biol. 28, 4562-4575
   Abstract »    Full Text »    PDF »
Acetylation of mitogen-activated protein kinase phosphatase-1 inhibits Toll-like receptor signaling.
W. Cao, C. Bao, E. Padalko, and C. J. Lowenstein (2008)
J. Exp. Med. 205, 1491-1503
   Abstract »    Full Text »    PDF »
Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival.
M. R. Junttila, S.-P. Li, and J. Westermarck (2008)
FASEB J 22, 954-965
   Abstract »    Full Text »    PDF »
Role of JNK in network formation of human lung microvascular endothelial cells.
M. Medhora, A. Dhanasekaran, P. F. Pratt Jr., C. R. Cook, L. K. Dunn, S. K. Gruenloh, and E. R. Jacobs (2008)
Am J Physiol Lung Cell Mol Physiol 294, L676-L685
   Abstract »    Full Text »    PDF »
A cell-active inhibitor of mitogen-activated protein kinase phosphatases restores paclitaxel-induced apoptosis in dexamethasone-protected cancer cells.
A. Vogt, P. R. McDonald, A. Tamewitz, R. P. Sikorski, P. Wipf, J. J. Skoko III, and J. S. Lazo (2008)
Mol. Cancer Ther. 7, 330-340
   Abstract »    Full Text »    PDF »
ERK-Dependent MKP-1 Mediated Cisplatin Resistance in Human Ovarian Cancer Cells.
J. Wang, J.-Y. Zhou, and G. S. Wu (2007)
Cancer Res. 67, 11933-11941
   Abstract »    Full Text »    PDF »
Angiotensin II-Induced Mitogen-Activated Protein Kinase Phosphatase-1 Expression in Bovine Adrenal Glomerulosa Cells: Implications in Mineralocorticoid Biosynthesis.
A. J. Casal, S. Ryser, A. M. Capponi, and C. F. Wang-Buholzer (2007)
Endocrinology 148, 5573-5581
   Abstract »    Full Text »    PDF »
Corticosteroid Inhibition of Growth-Related Oncogene Protein-{alpha} via Mitogen-Activated Kinase Phosphatase-1 in Airway Smooth Muscle Cells.
R. Issa, S. Xie, N. Khorasani, M. Sukkar, I. M. Adcock, K.-Y. Lee, and K. F. Chung (2007)
J. Immunol. 178, 7366-7375
   Abstract »    Full Text »    PDF »
Asbestos-mediated CREB phosphorylation is regulated by protein kinase A and extracellular signal-regulated kinases 1/2.
C. A. Barlow, T. F. Barrett, A. Shukla, B. T. Mossman, and K. M. Lounsbury (2007)
Am J Physiol Lung Cell Mol Physiol 292, L1361-L1369
   Abstract »    Full Text »    PDF »
Modulation of Replicative Senescence of Diploid Human Cells by Nuclear ERK Signaling.
M. Tresini, A. Lorenzini, C. Torres, and V. J. Cristofalo (2007)
J. Biol. Chem. 282, 4136-4151
   Abstract »    Full Text »    PDF »
Dephosphorylation by Default, a Potential Mechanism for Regulation of Insulin Receptor Substrate-1/2, Akt, and ERK1/2.
R. Zhande, W. Zhang, Y. Zheng, E. Pendleton, Y. Li, R. D. Polakiewicz, and X. J. Sun (2006)
J. Biol. Chem. 281, 39071-39080
   Abstract »    Full Text »    PDF »
DUSP Meet Immunology: Dual Specificity MAPK Phosphatases in Control of the Inflammatory Response.
R. Lang, M. Hammer, and J. Mages (2006)
J. Immunol. 177, 7497-7504
   Abstract »    Full Text »    PDF »
Dynamic regulation of ERK2 nuclear translocation and mobility in living cells.
M. Costa, M. Marchi, F. Cardarelli, A. Roy, F. Beltram, L. Maffei, and G. M. Ratto (2006)
J. Cell Sci. 119, 4952-4963
   Abstract »    Full Text »    PDF »
Phosphatase Activation by Epidermal Growth Factor Family Ligands Regulates Extracellular Regulated Kinase Signaling in Undifferentiated Hen Granulosa Cells.
D. C. Woods and A. L. Johnson (2006)
Endocrinology 147, 4931-4940
   Abstract »    Full Text »    PDF »
The Oxygen Sensor Factor-Inhibiting Hypoxia-Inducible Factor-1 Controls Expression of Distinct Genes through the Bifunctional Transcriptional Character of Hypoxia-Inducible Factor-1{alpha}..
F. Dayan, D. Roux, M. C. Brahimi-Horn, J. Pouyssegur, and N. M. Mazure (2006)
Cancer Res. 66, 3688-3698
   Abstract »    Full Text »    PDF »
Protein kinase C{delta}-mediated proteasomal degradation of MAP kinase phosphatase-1 contributes to glutamate-induced neuronal cell death.
B.-H. Choi, E.-M. Hur, J.-H. Lee, D.-J. Jun, and K.-T. Kim (2006)
J. Cell Sci. 119, 1329-1340
   Abstract »    Full Text »    PDF »
Regulation of sprouty stability by mnk1-dependent phosphorylation..
J. DaSilva, L. Xu, H. J. Kim, W. T. Miller, and D. Bar-Sagi (2006)
Mol. Cell. Biol. 26, 1898-1907
   Abstract »    Full Text »    PDF »
Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses.
H. Chi, S. P. Barry, R. J. Roth, J. J. Wu, E. A. Jones, A. M. Bennett, and R. A. Flavell (2006)
PNAS 103, 2274-2279
   Abstract »    Full Text »    PDF »
Cooperation of ERK and SCFSkp2 for MKP-1 Destruction Provides a Positive Feedback Regulation of Proliferating Signaling.
Y.-W. Lin and J.-L. Yang (2006)
J. Biol. Chem. 281, 915-926
   Abstract »    Full Text »    PDF »
Catalytic Activation of the Plant MAPK Phosphatase NtMKP1 by Its Physiological Substrate Salicylic Acid-induced Protein Kinase but Not by Calmodulins.
S. Katou, E. Karita, H. Yamakawa, S. Seo, I. Mitsuhara, K. Kuchitsu, and Y. Ohashi (2005)
J. Biol. Chem. 280, 39569-39581
   Abstract »    Full Text »    PDF »
Puckered, a Drosophila MAPK phosphatase, ensures cell viability by antagonizing JNK-induced apoptosis.
D. G. McEwen and M. Peifer (2005)
Development 132, 3935-3946
   Abstract »    Full Text »    PDF »
Ras-ERK MAPK Cascade Regulates GATA3 Stability and Th2 Differentiation through Ubiquitin-Proteasome Pathway.
M. Yamashita, R. Shinnakasu, H. Asou, M. Kimura, A. Hasegawa, K. Hashimoto, N. Hatano, M. Ogata, and T. Nakayama (2005)
J. Biol. Chem. 280, 29409-29419
   Abstract »    Full Text »    PDF »
Bowman-Birk inhibitor abates proteasome function and suppresses the proliferation of MCF7 breast cancer cells through accumulation of MAP kinase phosphatase-1.
Y.-W. Chen, S.-C. Huang, S.-Y. Lin-Shiau, and J.-K. Lin (2005)
Carcinogenesis 26, 1296-1306
   Abstract »    Full Text »    PDF »
Estrogen-induced changes in IGF-I, Myb family and MAP kinase pathway genes in human uterine leiomyoma and normal uterine smooth muscle cell lines.
C.D. Swartz, C.A. Afshari, L. Yu, K.E. Hall, and D. Dixon (2005)
Mol. Hum. Reprod. 11, 441-450
   Abstract »    Full Text »    PDF »
Ubiquitin Chains in the Ladder of MAPK Signaling.
A. Laine and Z. Ronai (2005)
Sci. STKE 2005, re5
   Abstract »    Full Text »    PDF »
Phosphorylation of Ser-446 Determines Stability of MKP-7.
C. Katagiri, K. Masuda, T. Urano, K. Yamashita, Y. Araki, K. Kikuchi, and H. Shima (2005)
J. Biol. Chem. 280, 14716-14722
   Abstract »    Full Text »    PDF »
Preheating Accelerates Mitogen-activated Protein (MAP) Kinase Inactivation Post-heat Shock via a Heat Shock Protein 70-mediated Increase in Phosphorylated MAP Kinase Phosphatase-1.
K.-H. Lee, C.-T. Lee, Y. W. Kim, S. K. Han, Y.-S. Shim, and C.-G. Yoo (2005)
J. Biol. Chem. 280, 13179-13186
   Abstract »    Full Text »    PDF »
The Role of Mitogen-activated Protein Kinase Phosphatase-1 in the Response of Alveolar Macrophages to Lipopolysaccharide: ATTENUATION OF PROINFLAMMATORY CYTOKINE BIOSYNTHESIS VIA FEEDBACK CONTROL OF p38.
Q. Zhao, E. G. Shepherd, M. E. Manson, L. D. Nelin, A. Sorokin, and Y. Liu (2005)
J. Biol. Chem. 280, 8101-8108
   Abstract »    Full Text »    PDF »
Reversible Oxidation of ERK-directed Protein Phosphatases Drives Oxidative Toxicity in Neurons.
D. J. Levinthal and D. B. DeFranco (2005)
J. Biol. Chem. 280, 5875-5883
   Abstract »    Full Text »    PDF »
Extracellular Signal-Regulated Kinases Phosphorylate Mitogen-Activated Protein Kinase Phosphatase 3/DUSP6 at Serines 159 and 197, Two Sites Critical for Its Proteasomal Degradation.
S. Marchetti, C. Gimond, J.-C. Chambard, T. Touboul, D. Roux, J. Pouyssegur, and G. Pages (2005)
Mol. Cell. Biol. 25, 854-864
   Abstract »    Full Text »    PDF »
Atrial Natriuretic Peptide Induces Mitogen-Activated Protein Kinase Phosphatase-1 in Human Endothelial Cells via Rac1 and NAD(P)H Oxidase/Nox2-Activation.
R. Furst, C. Brueckl, W. M. Kuebler, S. Zahler, F. Krotz, A. Gorlach, A. M. Vollmar, and A. K. Kiemer (2005)
Circ. Res. 96, 43-53
   Abstract »    Full Text »    PDF »
Spred-1 Negatively Regulates Interleukin-3-mediated ERK/Mitogen-activated Protein (MAP) Kinase Activation in Hematopoietic Cells.
A. Nonami, R. Kato, K. Taniguchi, D. Yoshiga, T. Taketomi, S. Fukuyama, M. Harada, A. Sasaki, and A. Yoshimura (2004)
J. Biol. Chem. 279, 52543-52551
   Abstract »    Full Text »    PDF »
Norepinephrine Induction of Mitogen-Activated Protein Kinase Phosphatase-1 Expression in Rat Pinealocytes: Distinct Roles of {alpha}- and {beta}-Adrenergic Receptors.
D. M. Price, C. L. Chik, and A. K. Ho (2004)
Endocrinology 145, 5723-5733
   Abstract »    Full Text »    PDF »
MAP Kinase Phosphatase 3 (MKP3) Interacts with and Is Phosphorylated by Protein Kinase CK2{alpha}.
M. Castelli, M. Camps, C. Gillieron, D. Leroy, S. Arkinstall, C. Rommel, and A. Nichols (2004)
J. Biol. Chem. 279, 44731-44739
   Abstract »    Full Text »    PDF »
Mechanisms Regulating the Constitutive Activation of the Extracellular Signal-Regulated Kinase (ERK) Signaling Pathway in Ovarian Cancer and the Effect of Ribonucleic Acid Interference for ERK1/2 on Cancer Cell Proliferation.
R. Steinmetz, H. A. Wagoner, P. Zeng, J. R. Hammond, T. S. Hannon, J. L. Meyers, and O. H. Pescovitz (2004)
Mol. Endocrinol. 18, 2570-2582
   Abstract »    Full Text »    PDF »
MKP-1 expression and stabilization and cGK I{alpha} prevent diabetes- associated abnormalities in VSMC migration.
A. Jacob, A. Smolenski, S. M. Lohmann, and N. Begum (2004)
Am J Physiol Cell Physiol 287, C1077-C1086
   Abstract »    Full Text »    PDF »
L-Type Ca2+ Channels Mediate Adaptation of Extracellular Signal-Regulated Kinase 1/2 Phosphorylation in the Ventral Tegmental Area after Chronic Amphetamine Treatment.
A. Rajadhyaksha, I. Husson, S. S. Satpute, K. D. Kuppenbender, J. Q. Ren, R. M. Guerriero, D. G. Standaert, and B. E. Kosofsky (2004)
J. Neurosci. 24, 7464-7476
   Abstract »    Full Text »    PDF »
Mitogen-activated Protein Kinase Phosphatase-3 Is a Tumor Promoter Target in Initiated Cells That Express Oncogenic Ras.
J. K. Warmka, L. J. Mauro, and E. V. Wattenberg (2004)
J. Biol. Chem. 279, 33085-33092
   Abstract »    Full Text »    PDF »
Prolonged Extracellular Signal-Regulated Kinase 1/2 Activation during Fibroblast Growth Factor 1- or Heregulin {beta}1-Induced Antiestrogen-Resistant Growth of Breast Cancer Cells Is Resistant to Mitogen-Activated Protein/Extracellular Regulated Kinase Kinase Inhibitors.
J. V. Thottassery, Y. Sun, L. Westbrook, S. S. Rentz, M. Manuvakhova, Z. Qu, S. Samuel, R. Upshaw, A. Cunningham, and F. G. Kern (2004)
Cancer Res. 64, 4637-4647
   Abstract »    Full Text »    PDF »
Nerve Growth Factor-dependent Survival of CESS B Cell Line Is Mediated by Increased Expression and Decreased Degradation of MAPK Phosphatase 1.
P. Rosini, G. De Chiara, P. Bonini, M. Lucibello, M. E. Marcocci, E. Garaci, F. Cozzolino, and M. Torcia (2004)
J. Biol. Chem. 279, 14016-14023
   Abstract »    Full Text »    PDF »
Reciprocal Regulation between Slt2 MAPK and Isoforms of Msg5 Dual-specificity Protein Phosphatase Modulates the Yeast Cell Integrity Pathway.
M. Flandez, I. C. Cosano, C. Nombela, H. Martin, and M. Molina (2004)
J. Biol. Chem. 279, 11027-11034
   Abstract »    Full Text »    PDF »
Microarray Analysis Reveals Glucocorticoid-Regulated Survival Genes That Are Associated With Inhibition of Apoptosis in Breast Epithelial Cells.
W. Wu, S. Chaudhuri, D. R. Brickley, D. Pang, T. Karrison, and S. D. Conzen (2004)
Cancer Res. 64, 1757-1764
   Abstract »    Full Text »    PDF »
Regulation of Ras-MAPK pathway mitogenic activity by restricting nuclear entry of activated MAPK in endoderm differentiation of embryonic carcinoma and stem cells.
E. R. Smith, J. L. Smedberg, M. E. Rula, and X.-X. Xu (2004)
J. Cell Biol. 164, 689-699
   Abstract »    Full Text »    PDF »
Jak2 Tyrosine Kinase Mediates Angiotensin II-dependent Inactivation of ERK2 via Induction of Mitogen-activated Protein Kinase Phosphatase 1.
E. M. Sandberg, X. Ma, D. VonDerLinden, M. D. Godeny, and P. P. Sayeski (2004)
J. Biol. Chem. 279, 1956-1967
   Abstract »    Full Text »    PDF »
Alterations in Subcellular Localization of p38 MAPK Potentiates Endothelin-stimulated COX-2 Expression in Glomerular Mesangial Cells.
P. F. Pratt, D. Bokemeyer, M. Foschi, A. Sorokin, and M. J. Dunn (2003)
J. Biol. Chem. 278, 51928-51936
   Abstract »    Full Text »    PDF »
Repression of Mitogen-Activated Protein Kinase (MAPK) Phosphatase-1 by Anthracyclines Contributes to Their Antiapoptotic Activation of p44/42-MAPK.
G. W. Small, S. Somasundaram, D. T. Moore, Y. Y. Shi, and R. Z. Orlowski (2003)
J. Pharmacol. Exp. Ther. 307, 861-869
   Abstract »    Full Text »    PDF »
Sphingosine-1-Phosphate Inhibition of Apoptosis Requires Mitogen-Activated Protein Kinase Phosphatase-1 in Mouse Fibroblast C3H10T1/2 Cells.
S. S. Castillo and D. Teegarden (2003)
J. Nutr. 133, 3343-3349
   Abstract »    Full Text »    PDF »
Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice.
R. J. Ferrante, J. K. Kubilus, J. Lee, H. Ryu, A. Beesen, B. Zucker, K. Smith, N. W. Kowall, R. R. Ratan, R. Luthi-Carter, et al. (2003)
J. Neurosci. 23, 9418-9427
   Abstract »    Full Text »    PDF »
Activation of ERK Induces Phosphorylation of MAPK Phosphatase-7, a JNK Specific Phosphatase, at Ser-446.
K. Masuda, H. Shima, C. Katagiri, and K. Kikuchi (2003)
J. Biol. Chem. 278, 32448-32456
   Abstract »    Full Text »    PDF »
Acute Induction of Conserved Synaptic Signaling Pathways in Drosophila Melanogaster.
C. A. Hoeffer, S. Sanyal, and M. Ramaswami (2003)
J. Neurosci. 23, 6362-6372
   Abstract »    Full Text »    PDF »
ERK1/2 Achieves Sustained Activation by Stimulating MAPK Phosphatase-1 Degradation via the Ubiquitin-Proteasome Pathway.
Y.-W. Lin, S.-M. Chuang, and J.-L. Yang (2003)
J. Biol. Chem. 278, 21534-21541
   Abstract »    Full Text »    PDF »
Gene Array and Protein Expression Profiles Suggest Post-transcriptional Regulation during CD8+ T Cell Differentiation.
C. M. Cham, H. Xu, J. P. O'Keefe, F. V. Rivas, P. Zagouras, and T. F. Gajewski (2003)
J. Biol. Chem. 278, 17044-17052
   Abstract »    Full Text »    PDF »
Differential regulation of p38 mitogen-activated protein kinase mediates gender-dependent catecholamine-induced hypertrophy.
R. Dash, A. G Schmidt, A. Pathak, M. J Gerst, D. Biniakiewicz, V. J Kadambi, B. D Hoit, W. T Abraham, and E. G Kranias (2003)
Cardiovasc Res 57, 704-714
   Abstract »    Full Text »    PDF »
Inhibition of Protein Tyrosine/Mitogen-Activated Protein Kinase Phosphatase Activity Is Associated with D2 Dopamine Receptor Supersensitivity in a Rat Model of Parkinson's Disease.
X. Zhen, C. Torres, G. Cai, and E. Friedman (2002)
Mol. Pharmacol. 62, 1356-1363
   Abstract »    Full Text »    PDF »
Restraint of Proinflammatory Cytokine Biosynthesis by Mitogen-Activated Protein Kinase Phosphatase-1 in Lipopolysaccharide-Stimulated Macrophages.
P. Chen, J. Li, J. Barnes, G. C. Kokkonen, J. C. Lee, and Y. Liu (2002)
J. Immunol. 169, 6408-6416
   Abstract »    Full Text »    PDF »
Dexamethasone Causes Sustained Expression of Mitogen-Activated Protein Kinase (MAPK) Phosphatase 1 and Phosphatase-Mediated Inhibition of MAPK p38.
M. Lasa, S. M. Abraham, C. Boucheron, J. Saklatvala, and A. R. Clark (2002)
Mol. Cell. Biol. 22, 7802-7811
   Abstract »    Full Text »    PDF »
Sustained Activation of the Extracellular Signal-regulated Kinase Pathway Protects Cells from Photofrin-mediated Photodynamic Therapy.
Z. Tong, G. Singh, and A. J. Rainbow (2002)
Cancer Res. 62, 5528-5535
   Abstract »    Full Text »    PDF »
The Dual Specificity JKAP Specifically Activates the c-Jun N-terminal Kinase Pathway.
A. J. Chen, G. Zhou, T. Juan, S. M. Colicos, J. P. Cannon, M. Cabriera-Hansen, C. F. Meyer, R. Jurecic, N. G. Copeland, D. J. Gilbert, et al. (2002)
J. Biol. Chem. 277, 36592-36601
   Abstract »    Full Text »    PDF »
Glucocorticoids Inhibit Lung Cancer Cell Growth through Both the Extracellular Signal-Related Kinase Pathway and Cell Cycle Regulators.
A. K. Greenberg, J. Hu, S. Basu, J. Hay, J. Reibman, T.-a. Yie, K. M. Tchou-Wong, W. N. Rom, and T. C. Lee (2002)
Am. J. Respir. Cell Mol. Biol. 27, 320-328
   Abstract »    Full Text »    PDF »
MAP Kinase Phosphatase As a Locus of Flexibility in a Mitogen-Activated Protein Kinase Signaling Network.
U. S. Bhalla, P. T. Ram, and R. Iyengar (2002)
Science 297, 1018-1023
   Abstract »    Full Text »    PDF »
Evidence That Inhibition of p44/42 Mitogen-activated Protein Kinase Signaling Is a Factor in Proteasome Inhibitor-mediated Apoptosis.
R. Z. Orlowski, G. W. Small, and Y. Y. Shi (2002)
J. Biol. Chem. 277, 27864-27871
   Abstract »    Full Text »    PDF »
Identification of Two Sp1 Phosphorylation Sites for p42/p44 Mitogen-activated Protein Kinases. THEIR IMPLICATION IN VASCULAR ENDOTHELIAL GROWTH FACTOR GENE TRANSCRIPTION.
J. Milanini-Mongiat, J. Pouyssegur, and G. Pages (2002)
J. Biol. Chem. 277, 20631-20639
   Abstract »    Full Text »    PDF »
Cross-talk between ERK and p38 MAPK Mediates Selective Suppression of Pro-inflammatory Cytokines by Transforming Growth Factor-beta.
Y. Q. Xiao, K. Malcolm, G. S. Worthen, S. Gardai, W. P. Schiemann, V. A. Fadok, D. L. Bratton, and P. M. Henson (2002)
J. Biol. Chem. 277, 14884-14893
   Abstract »    Full Text »    PDF »
Estrogen Activates Phosphatases and Antagonizes Growth-Promoting Effect of Angiotensin II.
Y. Takeda-Matsubara, H. Nakagami, M. Iwai, T.-X. Cui, T. Shiuchi, M. Akishita, C. Nahmias, M. Ito, and M. Horiuchi (2002)
Hypertension 39, 41-45
   Abstract »    Full Text »    PDF »
Transcriptional Induction of MKP-1 in Response to Stress Is Associated with Histone H3 Phosphorylation-Acetylation.
J. Li, M. Gorospe, D. Hutter, J. Barnes, S. M. Keyse, and Y. Liu (2001)
Mol. Cell. Biol. 21, 8213-8224
   Abstract »    Full Text »    PDF »
Hyperactivation of p21ras and the Hematopoietic-specific Rho GTPase, Rac2, Cooperate to Alter the Proliferation of Neurofibromin-deficient Mast Cells In Vivo and In Vitro.
D. A. Ingram, K. Hiatt, A. J. King, L. Fisher, R. Shivakumar, C. Derstine, M. J. Wenning, B. Diaz, J. B. Travers, A. Hood, et al. (2001)
J. Exp. Med. 194, 57-70
   Abstract »    Full Text »    PDF »
PTP-{epsilon}, a tyrosine phosphatase expressed in endothelium, negatively regulates endothelial cell proliferation.
L. J. Thompson, J. Jiang, N. Madamanchi, M. S. Runge, and C. Patterson (2001)
Am J Physiol Heart Circ Physiol 281, H396-H403
   Abstract »    Full Text »    PDF »
Insulin-Induced c-Jun N-Terminal Kinase Activation Is Negatively Regulated by Protein Kinase C {{delta}}.
K. Morino, H. Maegawa, T. Fujita, N. Takahara, K. Egawa, A. Kashiwagi, and R. Kikkawa (2001)
Endocrinology 142, 2669-2676
   Abstract »    Full Text »    PDF »
Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions.
G. Pearson, F. Robinson, T. Beers Gibson, B.-e Xu, M. Karandikar, K. Berman, and M. H. Cobb (2001)
Endocr. Rev. 22, 153-183
   Abstract »    Full Text »
Mitogen-activated protein kinase phosphatase is required for genotoxic stress relief in Arabidopsis.
R. Ulm, E. Revenkova, G.-P. di Sansebastiano, N. Bechtold, and J. Paszkowski (2001)
Genes & Dev. 15, 699-709
   Abstract »    Full Text »
The proteasome regulates the UV-induced activation of the AP-1-like transcription factor Gcn4.
M. L. Stitzel, R. Durso, and J. C. Reese (2001)
Genes & Dev. 15, 128-133
   Abstract »    Full Text »
The nucleus, a site for signal termination by sequestration and inactivation of p42/p44 MAP kinases.
V. Volmat, M. Camps, S. Arkinstall, J. Pouyssegur, and P. Lenormand (2001)
J. Cell Sci. 114, 3433-3443
   Abstract »    Full Text »    PDF »
Ptc1, a Type 2C Ser/Thr Phosphatase, Inactivates the HOG Pathway by Dephosphorylating the Mitogen-Activated Protein Kinase Hog1.
J. Warmka, J. Hanneman, J. Lee, D. Amin, and I. Ota (2001)
Mol. Cell. Biol. 21, 51-60
   Abstract »    Full Text »
Herpes Simplex Virus Type 1 ICP0 Protein Does Not Accumulate in the Nucleus of Primary Neurons in Culture.
X.-p. Chen, J. Li, M. Mata, J. Goss, D. Wolfe, J. C. Glorioso, and D. J. Fink (2000)
J. Virol. 74, 10132-10141
   Abstract »    Full Text »
Sequential Activation of ERK and Repression of JNK by Scatter Factor/Hepatocyte Growth Factor in Madin-Darby Canine Kidney Epithelial Cells.
R. Paumelle, D. Tulasne, C. Leroy, J. Coll, B. Vandenbunder, and V. Fafeur (2000)
Mol. Biol. Cell 11, 3751-3763
   Abstract »    Full Text »
A Constitutive Active MEK right-arrow ERK Pathway Negatively Regulates NF-kappa B-dependent Gene Expression by Modulating TATA-binding Protein Phosphorylation.
A. B. Carter and G. W. Hunninghake (2000)
J. Biol. Chem. 275, 27858-27864
   Abstract »    Full Text »    PDF »
Regulation of Dual-specificity Phosphatases M3/6 and hVH5 by Phorbol Esters. ANALYSIS OF A DELTA-LIKE DOMAIN.
T. R. Johnson, J. R. Biggs, S. E. Winbourn, and A. S. Kraft (2000)
J. Biol. Chem. 275, 31755-31762
   Abstract »    Full Text »    PDF »
MAP Kinase Phosphatase-1 Gene Transcription in Rat Neuroendocrine Cells Is Modulated by a Calcium-sensitive Block to Elongation in the First Exon.
S. Ryser, S. Tortola, G. van Haasteren, M. Muda, S. Li, and W. Schlegel (2001)
J. Biol. Chem. 276, 33319-33327
   Abstract »    Full Text »    PDF »
Activation of p42 Mitogen-activated Protein Kinase (MAPK), but not c-Jun NH2-Terminal Kinase, Induces Phosphorylation and Stabilization of MAPK Phosphatase XCL100 in Xenopus Oocytes.
M. L. Sohaskey and J. E. Ferrell Jr. (2002)
Mol. Biol. Cell 13, 454-468
   Abstract »    Full Text »    PDF »
Thrombomodulin Prolongs Thrombin-Induced Extracellular Signal-Regulated Kinase Phosphorylation and Nuclear Retention in Endothelial Cells.
J.-M. Olivot, E. Estebanell, M. Lafay, B. Brohard, M. Aiach, and F. Rendu (2001)
Circ. Res. 88, 681-687
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)