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Science 10 December 1999:
Vol. 286. no. 5447, pp. 2176 - 2179
DOI: 10.1126/science.286.5447.2176
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Reports

Mouse Tumor Model for Neurofibromatosis Type 1 

Kristine S. Vogel, 1*dagger Laura J. Klesse, 1* Susana Velasco-Miguel, 1* Kimberly Meyers, 1* Elizabeth J. Rushing, 2 Luis F. Parada 1ddagger

Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder characterized by increased incidence of benign and malignant tumors of neural crest origin. Mutations that activate the protooncogene ras, such as loss of Nf1, cooperate with inactivating mutations at the p53 tumor suppressor gene during malignant transformation. One hundred percent of mice harboring null Nf1 and p53 alleles in cis synergize to develop soft tissue sarcomas between 3 and 7 months of age. These sarcomas exhibit loss of heterozygosity at both gene loci and express phenotypic traits characteristic of neural crest derivatives and human NF1 malignancies.

1 Center for Developmental Biology and
2 Department of Pathology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd., Dallas, TX 75235-9133, USA.
*   These authors contributed equally to this work.

dagger    Present address: Department of Cell Biology and Anatomy, Louisiana State University Medical Center, New Orleans, LA 70112, USA.

ddagger    To whom correspondence should be addressed. E-mail: parada{at}utsw.swmed.edu

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