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Science 10 December 1999:
Vol. 286. no. 5447, pp. 2096 - 2097
DOI: 10.1126/science.286.5447.2096
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Perspectives

CANCER:
Structural Assets of a Tumor Suppressor

Nicholas K. Tonks and Michael P. Myers

PTEN is one of the most frequently mutated tumor suppressor proteins in human cancer. Many investigators are interested in what this protein does and how disruption of its activity enables cells to circumvent growth control. In a Perspective, Tonks and Myers discuss the recent publication of the crystal structure of PTEN and what the structure tells us about PTEN's ability to remove phosphate groups from proteins and phospholipids and how this relates to its anti-cancer function.

The authors are at the Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA. E-mail: tonks{at}cshl.org

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Phosphatidylinositol 3-Kinase/AKT-mediated Activation of Estrogen Receptor alpha . A NEW MODEL FOR ANTI-ESTROGEN RESISTANCE.
R. A. Campbell, P. Bhat-Nakshatri, N. M. Patel, D. Constantinidou, S. Ali, and H. Nakshatri (2001)
J. Biol. Chem. 276, 9817-9824
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Science. ISSN 0036-8075 (print), 1095-9203 (online)