Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 3 December 1999:
Vol. 286. no. 5446, pp. 1897 - 1905
DOI: 10.1126/science.286.5446.1897
Prev | Table of Contents | Next

Review

Quality Control by DNA Repair

Tomas Lindahl, Richard D. Wood

Faithful maintenance of the genome is crucial to the individual and to species. DNA damage arises from both endogenous sources such as water and oxygen and exogenous sources such as sunlight and tobacco smoke. In human cells, base alterations are generally removed by excision repair pathways that counteract the mutagenic effects of DNA lesions. This serves to maintain the integrity of the genetic information, although not all of the pathways are absolutely error-free. In some cases, DNA damage is not repaired but is instead bypassed by specialized DNA polymerases.

Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Herts, EN6 3LD, UK.

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Polymorphisms in the DNA repair gene XRCC1 and associations with systemic lupus erythematosus risk in the Taiwanese Han Chinese population.
Y-J. Lin, L. Wan, C-M. Huang, S-Y. Chen, Y-C. Huang, C-H. Lai, W-Y. Lin, H-P. Liu, Y-S. Wu, C-M. Chen, et al. (2009)
Lupus 18, 1246-1251
   Abstract »    PDF »
Lung inflammation is associated with reduced pulmonary nucleotide excision repair in vivo.
N. Gungor, A. Haegens, A. M. Knaapen, R. W.L. Godschalk, R. K. Chiu, E. F.M. Wouters, and F. J. van Schooten (2009)
Mutagenesis
   Abstract »    Full Text »    PDF »
Enhanced gene repair mediated by methyl-CpG-modified single-stranded oligonucleotides.
C. Bertoni, A. Rustagi, and T. A. Rando (2009)
Nucleic Acids Res.
   Abstract »    Full Text »    PDF »
Small Interfering RNA-Directed Knockdown of Uracil DNA Glycosylase Induces Apoptosis and Sensitizes Human Prostate Cancer Cells to Genotoxic Stress.
S. M. K. Pulukuri, J. A. Knost, N. Estes, and J. S. Rao (2009)
Mol. Cancer Res. 7, 1285-1293
   Abstract »    Full Text »    PDF »
Human DNA polymerase {beta} polymorphism, Arg137Gln, impairs its polymerase activity and interaction with PCNA and the cellular base excision repair capacity.
Z. Guo, L. Zheng, H. Dai, M. Zhou, H. Xu, and B. Shen (2009)
Nucleic Acids Res. 37, 3431-3441
   Abstract »    Full Text »    PDF »
PCNA monoubiquitylation and DNA polymerase {eta} ubiquitin-binding domain are required to prevent 8-oxoguanine-induced mutagenesis in Saccharomyces cerevisiae.
P. A. van der Kemp, M. de Padula, G. Burguiere-Slezak, H. D. Ulrich, and S. Boiteux (2009)
Nucleic Acids Res. 37, 2549-2559
   Abstract »    Full Text »    PDF »
Association between genetic polymorphisms of DNA base excision repair genes and evolution of precancerous gastric lesions in a Chinese population.
W.-Q. Li, L. Zhang, J.-L. Ma, Y. Zhang, J.-Y. Li, K.-F. Pan, and W.-C. You (2009)
Carcinogenesis 30, 500-505
   Abstract »    Full Text »    PDF »
Human Nei-like protein NEIL3 has AP lyase activity specific for single-stranded DNA and confers oxidative stress resistance in Escherichia coli mutant..
M. Takao, Y. Oohata, K. Kitadokoro, K. Kobayashi, S. Iwai, A. Yasui, S. Yonei, and Q.-M. Zhang (2009)
Genes Cells 14, 261-270
   Abstract »    Full Text »    PDF »
Spatial organization of nucleotide excision repair proteins after UV-induced DNA damage in the human cell nucleus.
L. Solimando, M. S. Luijsterburg, L. Vecchio, W. Vermeulen, R. van Driel, and S. Fakan (2009)
J. Cell Sci. 122, 83-91
   Abstract »    Full Text »    PDF »
Mutagenesis Is Elevated in Male Germ Cells Obtained from DNA Polymerase-beta Heterozygous Mice.
D. Allen, D. C. Herbert, C. A. McMahan, V. Rotrekl, R. W. Sobol, S. H. Wilson, and C. A. Walter (2008)
Biol Reprod 79, 824-831
   Abstract »    Full Text »    PDF »
Editing of misaligned 3'-termini by an intrinsic 3'-5' exonuclease activity residing in the PHP domain of a family X DNA polymerase.
B. Banos, J. M. Lazaro, L. Villar, M. Salas, and M. de Vega (2008)
Nucleic Acids Res. 36, 5736-5749
   Abstract »    Full Text »    PDF »
PARP-1 cooperates with Ptc1 to suppress medulloblastoma and basal cell carcinoma.
M. Tanori, M. Mancuso, E. Pasquali, S. Leonardi, S. Rebessi, V. Di Majo, M.-N. Guilly, F. Giangaspero, V. Covelli, S. Pazzaglia, et al. (2008)
Carcinogenesis 29, 1911-1919
   Abstract »    Full Text »    PDF »
Association between Polymorphisms in DNA Base Excision Repair Genes XRCC1, APE1, and ADPRT and Differentiated Thyroid Carcinoma.
F.-Y. Chiang, C.-W. Wu, P.-J. Hsiao, W.-R. Kuo, K.-W. Lee, J.-C. Lin, Y.-C. Liao, and S.-H. H. Juo (2008)
Clin. Cancer Res. 14, 5919-5924
   Abstract »    Full Text »    PDF »
Human Methyl Purine DNA Glycosylase and DNA Polymerase {beta} Expression Collectively Predict Sensitivity to Temozolomide.
R. N. Trivedi, X.-h. Wang, E. Jelezcova, E. M. Goellner, J.-b. Tang, and R. W. Sobol (2008)
Mol. Pharmacol. 74, 505-516
   Abstract »    Full Text »    PDF »
An O6-methylguanine-DNA Methyltransferase-like Protein from Thermus thermophilus Interacts with a Nucleotide Excision Repair Protein.
R. Morita, N. Nakagawa, S. Kuramitsu, and R. Masui (2008)
J. Biochem. 144, 267-277
   Abstract »    Full Text »    PDF »
Patients with ERCC1-Negative Locally Advanced Esophageal Cancers May Benefit from Preoperative Chemoradiotherapy.
M. K. Kim, K.-J. Cho, G. Y. Kwon, S.-I. Park, Y. H. Kim, J. H. Kim, H.-Y. Song, J. H. Shin, H. Y. Jung, G. H. Lee, et al. (2008)
Clin. Cancer Res. 14, 4225-4231
   Abstract »    Full Text »    PDF »
Hjm/Hel308A DNA Helicase from Sulfolobus tokodaii Promotes Replication Fork Regression and Interacts with Hjc Endonuclease In Vitro.
Z. Li, S. Lu, G. Hou, X. Ma, D. Sheng, J. Ni, and Y. Shen (2008)
J. Bacteriol. 190, 3006-3017
   Abstract »    Full Text »    PDF »
The Leu22Pro tumor-associated variant of DNA polymerase beta is dRP lyase deficient.
S. Dalal, A. Chikova, J. Jaeger, and J. B. Sweasy (2008)
Nucleic Acids Res. 36, 411-422
   Abstract »    Full Text »    PDF »
Dipole-Dipole Interaction Stabilizes the Transition State of Apurinic/Apyrimidinic Endonuclease Abasic Site Interaction.
S. Adhikari, A. Uren, and R. Roy (2008)
J. Biol. Chem. 283, 1334-1339
   Abstract »    Full Text »    PDF »
Isolation of XAB2 Complex Involved in Pre-mRNA Splicing, Transcription, and Transcription-coupled Repair.
I. Kuraoka, S. Ito, T. Wada, M. Hayashida, L. Lee, M. Saijo, Y. Nakatsu, M. Matsumoto, T. Matsunaga, H. Handa, et al. (2008)
J. Biol. Chem. 283, 940-950
   Abstract »    Full Text »    PDF »
Mutagen Sensitivity and Genetic Variants in Nucleotide Excision Repair Pathway: Genotype-Phenotype Correlation.
J. Lin, G. E. Swan, P. G. Shields, N. L. Benowitz, J. Gu, C. I. Amos, M. de Andrade, M. R. Spitz, and X. Wu (2007)
Cancer Epidemiol. Biomarkers Prev. 16, 2065-2071
   Abstract »    Full Text »    PDF »
Comparative assessment of plasmid and oligonucleotide DNA substrates in measurement of in vitro base excision repair activity.
E. W. Hou, R. Prasad, K. Asagoshi, A. Masaoka, and S. H. Wilson (2007)
Nucleic Acids Res. 35, e112
   Abstract »    Full Text »    PDF »
The human checkpoint sensor Rad9 Rad1 Hus1 interacts with and stimulates DNA repair enzyme TDG glycosylase.
X. Guan, A. Madabushi, D.-Y. Chang, M. E. Fitzgerald, G. Shi, A. C. Drohat, and A-L. Lu (2007)
Nucleic Acids Res. 35, 6207-6218
   Abstract »    Full Text »    PDF »
Excision of 5-Halogenated Uracils by Human Thymine DNA Glycosylase: ROBUST ACTIVITY FOR DNA CONTEXTS OTHER THAN CpG.
M. T. Morgan, M. T. Bennett, and A. C. Drohat (2007)
J. Biol. Chem. 282, 27578-27586
   Abstract »    Full Text »    PDF »
Excessive Activation of Poly(ADP-Ribose) Polymerase Contributes to Inherited Photoreceptor Degeneration in the Retinal Degeneration 1 Mouse.
F. Paquet-Durand, J. Silva, T. Talukdar, L. E. Johnson, S. Azadi, T. van Veen, M. Ueffing, S. M. Hauck, and P. A. R. Ekstrom (2007)
J. Neurosci. 27, 10311-10319
   Abstract »    Full Text »    PDF »
ATP-Dependent Chromatin Remodeling Is Required for Base Excision Repair in Conventional but Not in Variant H2A.Bbd Nucleosomes.
H. Menoni, D. Gasparutto, A. Hamiche, J. Cadet, S. Dimitrov, P. Bouvet, and D. Angelov (2007)
Mol. Cell. Biol. 27, 5949-5956
   Abstract »    Full Text »    PDF »
Activated neutrophils inhibit nucleotide excision repair in human pulmonary epithelial cells: role of myeloperoxidase.
N. Gungor, R. W.L. Godschalk, D. M. Pachen, F. J. Van Schooten, and A. M. Knaapen (2007)
FASEB J 21, 2359-2367
   Abstract »    Full Text »    PDF »
A Genetic Analysis of the Drosophila mcm5 Gene Defines a Domain Specifically Required for Meiotic Recombination.
C. M. Lake, K. Teeter, S. L. Page, R. Nielsen, and R. S. Hawley (2007)
Genetics 176, 2151-2163
   Abstract »    Full Text »    PDF »
Induction of Base Damages Representing a High Risk Site for Double-strand DNA Break Formation in Genomic DNA by Exposure of Cells to DNA Damaging Agents.
E. L. Y. Ho, M. Parent, and M. S. Satoh (2007)
J. Biol. Chem. 282, 21913-21923
   Abstract »    Full Text »    PDF »
Different structural states in oligonucleosomes are required for early versus late steps of base excision repair.
S. Nakanishi, R. Prasad, S. H. Wilson, and M. Smerdon (2007)
Nucleic Acids Res. 35, 4313-4321
   Abstract »    Full Text »    PDF »
Nucleotide Excision Repair Pathway Genes and Oral Premalignant Lesions.
Y. Wang, M. R. Spitz, J. J. Lee, M. Huang, S. M. Lippman, and X. Wu (2007)
Clin. Cancer Res. 13, 3753-3758
   Abstract »    Full Text »    PDF »
Prospective Assessment of XPD Lys751Gln and XRCC1 Arg399Gln Single Nucleotide Polymorphisms in Lung Cancer.
D. F. Giachino, P. Ghio, S. Regazzoni, G. Mandrile, S. Novello, G. Selvaggi, D. Gregori, M. DeMarchi, and G. V. Scagliotti (2007)
Clin. Cancer Res. 13, 2876-2881
   Abstract »    Full Text »    PDF »
Inhibition of Poly(ADP-Ribose) Polymerase Enhances Cell Death and Improves Tumor Growth Delay in Irradiated Lung Cancer Models.
J. M. Albert, C. Cao, K. W. Kim, C. D. Willey, L. Geng, D. Xiao, H. Wang, A. Sandler, D. H. Johnson, A. D. Colevas, et al. (2007)
Clin. Cancer Res. 13, 3033-3042
   Abstract »    Full Text »    PDF »
Overexpression of DNA polymerase {beta} results in an increased rate of frameshift mutations during base excision repair.
K. Chan, S. Houlbrook, Q.-M. Zhang, M. Harrison, I. D. Hickson, and G. L. Dianov (2007)
Mutagenesis 22, 183-188
   Abstract »    Full Text »    PDF »
ABT-888, an Orally Active Poly(ADP-Ribose) Polymerase Inhibitor that Potentiates DNA-Damaging Agents in Preclinical Tumor Models.
C. K. Donawho, Y. Luo, Y. Luo, T. D. Penning, J. L. Bauch, J. J. Bouska, V. D. Bontcheva-Diaz, B. F. Cox, T. L. DeWeese, L. E. Dillehay, et al. (2007)
Clin. Cancer Res. 13, 2728-2737
   Abstract »    Full Text »    PDF »
Knockdown of DNA Ligase IV/XRCC4 by RNA Interference Inhibits Herpes Simplex Virus Type I DNA Replication.
I. Muylaert and P. Elias (2007)
J. Biol. Chem. 282, 10865-10872
   Abstract »    Full Text »    PDF »
The checkpoint clamp, Rad9-Rad1-Hus1 complex, preferentially stimulates the activity of apurinic/apyrimidinic endonuclease 1 and DNA polymerase {beta} in long patch base excision repair.
A. Gembka, M. Toueille, E. Smirnova, R. Poltz, E. Ferrari, G. Villani, and U. Hubscher (2007)
Nucleic Acids Res.
   Abstract »    Full Text »    PDF »
Structural Characterization of Human 8-Oxoguanine DNA Glycosylase Variants Bearing Active Site Mutations.
C. T. Radom, A. Banerjee, and G. L. Verdine (2007)
J. Biol. Chem. 282, 9182-9194
   Abstract »    Full Text »    PDF »
Retinal Degeneration and Ionizing Radiation Hypersensitivity in a Mouse Model for Cockayne Syndrome.
T. G. M. F. Gorgels, I. van der Pluijm, R. M. C. Brandt, G. A. Garinis, H. van Steeg, G. van den Aardweg, G. H. Jansen, J. M. Ruijter, A. A. B. Bergen, D. van Norren, et al. (2007)
Mol. Cell. Biol. 27, 1433-1441
   Abstract »    Full Text »    PDF »
Knockdown of XAB2 Enhances All-Trans Retinoic Acid-Induced Cellular Differentiation in All-Trans Retinoic Acid-Sensitive and -Resistant Cancer Cells.
K. Ohnuma-Ishikawa, T. Morio, T. Yamada, Y. Sugawara, M. Ono, M. Nagasawa, A. Yasuda, C. Morimoto, K. Ohnuma, N. H. Dang, et al. (2007)
Cancer Res. 67, 1019-1029
   Abstract »    Full Text »    PDF »
Human RAD18 is involved in S phase-specific single-strand break repair without PCNA monoubiquitination.
N. Shiomi, M. Mori, H. Tsuji, T. Imai, H. Inoue, S. Tateishi, M. Yamaizumi, and T. Shiomi (2007)
Nucleic Acids Res. 35, e9
   Abstract »    Full Text »    PDF »
Association of Dnmt3a and thymine DNA glycosylase links DNA methylation with base-excision repair.
Y.-Q. Li, P.-Z. Zhou, X.-D. Zheng, C. P. Walsh, and G.-L. Xu (2007)
Nucleic Acids Res. 35, 390-400
   Abstract »    Full Text »    PDF »
Methylation of DNA polymerase {beta} by protein arginine methyltransferase 1 regulates its binding to proliferating cell nuclear antigen.
N. El-Andaloussi, T. Valovka, M. Toueille, P. O. Hassa, P. Gehrig, M. Covic, U. Hubscher, and M. O. Hottiger (2007)
FASEB J 21, 26-34
   Abstract »    Full Text »    PDF »
Transcription Domain-Associated Repair in Human Cells.
T. P. Nouspikel, N. Hyka-Nouspikel, and P. C. Hanawalt (2006)
Mol. Cell. Biol. 26, 8722-8730
   Abstract »    Full Text »    PDF »
Kinetic Effect of a Downstream Strand and Its 5'-Terminal Moieties on Single Nucleotide Gap-filling Synthesis Catalyzed by Human DNA Polymerase {lambda}.
W. W. Duym, K. A. Fiala, N. Bhatt, and Z. Suo (2006)
J. Biol. Chem. 281, 35649-35655
   Abstract »    Full Text »    PDF »
Replication-dependent and -independent Responses of RAD18 to DNA Damage in Human Cells.
S. Nakajima, L. Lan, S.-i. Kanno, N. Usami, K. Kobayashi, M. Mori, T. Shiomi, and A. Yasui (2006)
J. Biol. Chem. 281, 34687-34695
   Abstract »    Full Text »    PDF »
Genetic variants of the ADPRT, XRCC1 and APE1 genes and risk of cutaneous melanoma.
C. Li, Z. Liu, L.-E Wang, S. S. Strom, J. E. Lee, J. E. Gershenwald, M. I. Ross, P. F. Mansfield, J. N. Cormier, V. G. Prieto, et al. (2006)
Carcinogenesis 27, 1894-1901
   Abstract »    Full Text »    PDF »
Overexpression of lysosomal Acid lipase and other proteins in atherosclerosis..
O. Zschenker, T. Illies, and D. Ameis (2006)
J. Biochem. 140, 23-38
   Abstract »    Full Text »    PDF »
African Swine Fever Virus Protein pE296R Is a DNA Repair Apurinic/Apyrimidinic Endonuclease Required for Virus Growth in Swine Macrophages..
M. Redrejo-Rodriguez, R. Garcia-Escudero, R. J. Yanez-Munoz, M. L. Salas, and J. Salas (2006)
J. Virol. 80, 4847-4857
   Abstract »    Full Text »    PDF »
Base excision repair fidelity in normal and cancer cells.
K. K.L. Chan, Q.-M. Zhang, and G. L. Dianov (2006)
Mutagenesis 21, 173-178
   Abstract »    Full Text »    PDF »
Drosophila DNA Polymerase {zeta} Interacts with Recombination Repair Protein 1, the Drosophila Homologue of Human Abasic Endonuclease 1.
R. Takeuchi, T. Ruike, R.-i. Nakamura, K. Shimanouchi, Y. Kanai, Y. Abe, A. Ihara, and K. Sakaguchi (2006)
J. Biol. Chem. 281, 11577-11585
   Abstract »    Full Text »    PDF »
Valproic Acid Increases Conservative Homologous Recombination Frequency and Reactive Oxygen Species Formation: A Potential Mechanism for Valproic Acid-Induced Neural Tube Defects.
E. N. Defoort, P. M. Kim, and L. M. Winn (2006)
Mol. Pharmacol. 69, 1304-1310
   Abstract »    Full Text »    PDF »
Induction of CAF-1 Expression in Response to DNA Strand Breaks in Quiescent Human Cells..
A. Nabatiyan, D. Szuts, and T. Krude (2006)
Mol. Cell. Biol. 26, 1839-1849
   Abstract »    Full Text »    PDF »
URI-1 is required for DNA stability in C. elegans.
C. T. Parusel, E. A. Kritikou, M. O. Hengartner, W. Krek, and M. Gotta (2006)
Development 133, 621-629
   Abstract »    Full Text »    PDF »
DNA Polymerase {zeta} Accounts for the Reduced Cytotoxicity and Enhanced Mutagenicity of Cisplatin in Human Colon Carcinoma Cells That Have Lost DNA Mismatch Repair.
X. Lin, J. Trang, T. Okuda, and S. B. Howell (2006)
Clin. Cancer Res. 12, 563-568
   Abstract »    Full Text »    PDF »
MSH2 is essential for the preservation of genome integrity and prevents homeologous recombination in the moss Physcomitrella patens.
B. Trouiller, D. G. Schaefer, F. Charlot, and F. Nogue (2006)
Nucleic Acids Res. 34, 232-242
   Abstract »    Full Text »    PDF »
ERK Activation in Arsenite-Treated G1-Enriched CL3 Cells Contributes to Survival, DNA Repair Inhibition, and Micronucleus Formation.
J.-P. Li, J.-C. Lin, and J.-L. Yang (2006)
Toxicol. Sci. 89, 164-172
   Abstract »    Full Text »    PDF »
Error-prone Translesion Synthesis by Human DNA Polymerase {eta} on DNA-containing Deoxyadenosine Adducts of 7,8-Dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.
D. Chiapperino, M. Cai, J. M. Sayer, H. Yagi, H. Kroth, C. Masutani, F. Hanaoka, D. M. Jerina, and A. M. Cheh (2005)
J. Biol. Chem. 280, 39684-39692
   Abstract »    Full Text »    PDF »
Association of cytokine and DNA repair gene polymorphisms with hepatitis B-related hepatocellular carcinoma.
C.-C. Chen, S.-Y. Yang, C.-J. Liu, C.-L. Lin, Y.-F. Liaw, S.-M. Lin, S.-D. Lee, P.-J. Chen, C.-J. Chen, and M.-W. Yu (2005)
Int. J. Epidemiol. 34, 1310-1318
   Abstract »    Full Text »    PDF »
Genetic Polymorphisms in the Base Excision Repair Pathway and Cancer Risk: A HuGE Review.
R. J. Hung, J. Hall, P. Brennan, and P. Boffetta (2005)
Am. J. Epidemiol. 162, 925-942
   Abstract »    Full Text »    PDF »
Interindividual Variation in Nucleotide Excision Repair Genes and Risk of Endometrial Cancer.
J. M. Weiss, N. S. Weiss, C. M. Ulrich, J. A. Doherty, L. F. Voigt, and C. Chen (2005)
Cancer Epidemiol. Biomarkers Prev. 14, 2524-2530
   Abstract »    Full Text »    PDF »
Human Tdp1 Cleaves a Broad Spectrum of Substrates, Including Phosphoamide Linkages.
H. Interthal, H. J. Chen, and J. J. Champoux (2005)
J. Biol. Chem. 280, 36518-36528
   Abstract »    Full Text »    PDF »
Structural insights into abasic site for Fpg specific binding and catalysis: comparative high-resolution crystallographic studies of Fpg bound to various models of abasic site analogues-containing DNA.
K. P. de Jesus, L. Serre, C. Zelwer, and B. Castaing (2005)
Nucleic Acids Res. 33, 5936-5944
   Abstract »    Full Text »    PDF »
Carcinogenic Potential of Ovulatory Genotoxicity.
W. J. Murdoch (2005)
Biol Reprod 73, 586-590
   Abstract »    Full Text »    PDF »
NEIL1 excises 3' end proximal oxidative DNA lesions resistant to cleavage by NTH1 and OGG1.
J. L. Parsons, D. O. Zharkov, and G. L. Dianov (2005)
Nucleic Acids Res. 33, 4849-4856
   Abstract »    Full Text »    PDF »
Characterization of SpPol4, a unique X-family DNA polymerase in Schizosaccharomyces pombe.
S. Gonzalez-Barrera, A. Sanchez, J. F. Ruiz, R. Juarez, A. J. Picher, G. Terrados, P. Andrade, and L. Blanco (2005)
Nucleic Acids Res. 33, 4762-4774
   Abstract »    Full Text »    PDF »
Oxidative stress-induced apoptosis in neurons correlates with mitochondrial DNA base excision repair pathway imbalance.
J. F. Harrison, S. B. Hollensworth, D. R. Spitz, W. C. Copeland, G. L. Wilson, and S. P. LeDoux (2005)
Nucleic Acids Res. 33, 4660-4671
   Abstract »    Full Text »    PDF »
The DNA damage response and patient safety: engaging our molecular biology-oriented colleagues.
K. Pukk and D. C. Aron (2005)
Int. J. Qual. Health Care 17, 363-367
   Abstract »    Full Text »    PDF »
The Role of Base Excision Repair in the Sensitivity and Resistance to Temozolomide-Mediated Cell Death.
R. N. Trivedi, K. H. Almeida, J. L. Fornsaglio, S. Schamus, and R. W. Sobol (2005)
Cancer Res. 65, 6394-6400
   Abstract »    Full Text »    PDF »
Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks.
C. Lundin, M. North, K. Erixon, K. Walters, D. Jenssen, A. S. H. Goldman, and T. Helleday (2005)
Nucleic Acids Res. 33, 3799-3811
   Abstract »    Full Text »    PDF »
Interrogating DNA Repair in Cancer Risk Assessment.
T. Paz-Elizur, D. E. Brenner, and Z. Livneh (2005)
Cancer Epidemiol. Biomarkers Prev. 14, 1585-1587
   Full Text »    PDF »
The Genome Health Clinic and Genome Health Nutrigenomics concepts: diagnosis and nutritional treatment of genome and epigenome damage on an individual basis.
M. Fenech (2005)
Mutagenesis 20, 255-269
   Abstract »    Full Text »    PDF »
Impaired base excision repair and accumulation of oxidative base lesions in CD4+ T cells of HIV-infected patients.
P. Aukrust, L. Luna, T. Ueland, R. F. Johansen, F. Muller, S. S. Froland, E. C. Seeberg, and M. Bjoras (2005)
Blood 105, 4730-4735
   Abstract »    Full Text »    PDF »
Analysis of nuclear transport signals in the human apurinic/apyrimidinic endonuclease (APE1/Ref1).
E. B. Jackson, C. A. Theriot, R. Chattopadhyay, S. Mitra, and T. Izumi (2005)
Nucleic Acids Res. 33, 3303-3312
   Abstract »    Full Text »    PDF »
Large-Scale Investigation of Base Excision Repair Genetic Polymorphisms and Lung Cancer Risk in a Multicenter Study.
R. J. Hung, P. Brennan, F. Canzian, N. Szeszenia-Dabrowska, D. Zaridze, J. Lissowska, P. Rudnai, E. Fabianova, D. Mates, L. Foretova, et al. (2005)
J Natl Cancer Inst 97, 567-576
   Abstract »    Full Text »    PDF »
Comparative Genomics of Hemiascomycete Yeasts: Genes Involved in DNA Replication, Repair, and Recombination.
G.-F. Richard, A. Kerrest, I. Lafontaine, and B. Dujon (2005)
Mol. Biol. Evol. 22, 1011-1023
   Abstract »    Full Text »    PDF »
DNA Polymerase {beta} and Flap Endonuclease 1 Enzymatic Specificities Sustain DNA Synthesis for Long Patch Base Excision Repair.
Y. Liu, W. A. Beard, D. D. Shock, R. Prasad, E. W. Hou, and S. H. Wilson (2005)
J. Biol. Chem. 280, 3665-3674
   Abstract »    Full Text »    PDF »
Polymorphisms in XRCC1 Modify the Association between Polycyclic Aromatic Hydrocarbon-DNA Adducts, Cigarette Smoking, Dietary Antioxidants, and Breast Cancer Risk.
J. Shen, M. D. Gammon, M. B. Terry, L. Wang, Q. Wang, F. Zhang, S. L. Teitelbaum, S. M. Eng, S. K. Sagiv, M. M. Gaudet, et al. (2005)
Cancer Epidemiol. Biomarkers Prev. 14, 336-342
   Abstract »    Full Text »    PDF »
Formation of 8-oxo-7,8-dihydroguanine-radicals in {gamma}-irradiated DNA by multiple one-electron oxidations.
L. I. Shukla, A. Adhikary, R. Pazdro, D. Becker, and M. D. Sevilla (2004)
Nucleic Acids Res. 32, 6565-6574
   Abstract »    Full Text »    PDF »
Definition of a Short Region of XPG Necessary for TFIIH Interaction and Stable Recruitment to Sites of UV Damage.
F. Thorel, A. Constantinou, I. Dunand-Sauthier, T. Nouspikel, P. Lalle, A. Raams, N. G. J. Jaspers, W. Vermeulen, M. K. K. Shivji, R. D. Wood, et al. (2004)
Mol. Cell. Biol. 24, 10670-10680
   Abstract »    Full Text »    PDF »
A novel nuclease-ATPase (Nar71) from archaea is part of a proposed thermophilic DNA repair system.
C. P. Guy, A. I. Majernik, J. P. J. Chong, and E. L. Bolt (2004)
Nucleic Acids Res. 32, 6176-6186
   Abstract »    Full Text »    PDF »
UV Light-induced DNA Damage and Tolerance for the Survival of Nucleotide Excision Repair-deficient Human Cells.
S. Nakajima, L. Lan, S.-i. Kanno, M. Takao, K. Yamamoto, A. P. M. Eker, and A. Yasui (2004)
J. Biol. Chem. 279, 46674-46677
   Abstract »    Full Text »    PDF »
p53 Deficiency Rescues Neuronal Apoptosis but Not Differentiation in DNA Polymerase {beta}-Deficient Mice.
N. Sugo, N. Niimi, Y. Aratani, K. Takiguchi-Hayashi, and H. Koyama (2004)
Mol. Cell. Biol. 24, 9470-9477
   Abstract »    Full Text »    PDF »
A Coordinated Temporal Interplay of Nucleosome Reorganization Factor, Sister Chromatin Cohesion Factor, and DNA Polymerase {alpha} Facilitates DNA Replication.
Y. Zhou and T. S.-F. Wang (2004)
Mol. Cell. Biol. 24, 9568-9579
   Abstract »    Full Text »    PDF »
Reversible Cigarette Smoke Extract-Induced DNA Damage in Human Lung Fibroblasts.
H. Kim, X. Liu, T. Kobayashi, H. Conner, T. Kohyama, F.-Q. Wen, Q. Fang, S. Abe, P. Bitterman, and S. I. Rennard (2004)
Am. J. Respir. Cell Mol. Biol. 31, 483-490
   Abstract »    Full Text »    PDF »
Cdc7 Inhibition Reveals a p53-Dependent Replication Checkpoint That Is Defective in Cancer Cells.
A. Montagnoli, P. Tenca, F. Sola, D. Carpani, D. Brotherton, C. Albanese, and C. Santocanale (2004)
Cancer Res. 64, 7110-7116
   Abstract »    Full Text »    PDF »
Crystal Structure of the Endonuclease Domain Encoded by the Telomere-specific Long Interspersed Nuclear Element, TRAS1.
N. Maita, T. Anzai, H. Aoyagi, H. Mizuno, and H. Fujiwara (2004)
J. Biol. Chem. 279, 41067-41076
   Abstract »    Full Text »    PDF »
The post-replication repair RAD18 and RAD6 genes are involved in the prevention of spontaneous mutations caused by 7,8-dihydro-8-oxoguanine in Saccharomyces cerevisiae.
M. de Padula, G. Slezak, P. Auffret van Der Kemp, and S. Boiteux (2004)
Nucleic Acids Res. 32, 5003-5010
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)