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Science 26 November 1999:
Vol. 286. no. 5445, pp. 1732 - 1735
DOI: 10.1126/science.286.5445.1732
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Reports

Arthritis Provoked by Linked T and B Cell Recognition of a Glycolytic Enzyme

Isao Matsumoto, * Adrien Staub, Christophe Benoist, *dagger Diane Mathis *dagger

The hallmark of rheumatoid arthritis (RA) is specific destruction of the synovial joints. In a mouse line that spontaneously develops a disorder with many of the features of human RA, disease is initiated by T cell recognition of a ubiquitously expressed self-antigen; once initiated, pathology is driven almost entirely by immunoglobulins. In this study, the target of both the initiating T cells and pathogenic immunoglobulins was identified as glucose-6-phosphate isomerase, a glycolytic enzyme. Thus, some forms of RA or related arthritides may develop by a mechanism fundamentally different from the currently popular paradigm of a joint-specific T cell response.

Institut de Génétique et de Biologie Moléculaire et Cellulaire (CNRS/INSERM/ULP), BP 163, 67404 Illkirch, C.U. de Strasbourg, France.
*   Present address: Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA.

dagger    To whom correspondence should be addressed.

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Link between Organ-specific Antigen Processing by 20S Proteasomes and CD8+ T Cell-mediated Autoimmunity.
U. Kuckelkorn, T. Ruppert, B. Strehl, P. R. Jungblut, U. Zimny-Arndt, S. Lamer, I. Prinz, I. Drung, P.-M. Kloetzel, S. H.E. Kaufmann, et al. (2002)
J. Exp. Med. 195, 983-990
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Arthritogenic Monoclonal Antibodies from K/BxN Mice.
M. Maccioni, G. Zeder-Lutz, H. Huang, C. Ebel, P. Gerber, J. Hergueux, P. Marchal, V. Duchatelle, C. Degott, M. van Regenmortel, et al. (2002)
J. Exp. Med. 195, 1071-1077
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Innate Immunity as a Hired Gun: But Is It Rheumatoid Arthritis?.
M. Corr and G. S. Firestein (2002)
J. Exp. Med. 195, F33-F35
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