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Science 19 November 1999:
Vol. 286. no. 5444, pp. 1558 - 1561
DOI: 10.1126/science.286.5444.1558
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Reports

Transmission of Chronic Nociception by Spinal Neurons Expressing the Substance P Receptor

Michael L. Nichols, 12 Brian J. Allen, 12 Scott D. Rogers, 12 Joseph R. Ghilardi, 12 Prisca Honore, 12 Nancy M. Luger, 12 Matthew P. Finke, 12 Jun Li, 1 Douglas A. Lappi, 3 Donald A. Simone, 1 Patrick W. Mantyh 12*

Substance P receptor (SPR)-expressing spinal neurons were ablated with the selective cytotoxin substance P-saporin. Loss of these neurons resulted in a reduction of thermal hyperalgesia and mechanical allodynia associated with persistent neuropathic and inflammatory pain states. This loss appeared to be permanent. Responses to mildly painful stimuli and morphine analgesia were unaffected by this treatment. These results identify a target for treating persistent pain and suggest that the small population of SPR-expressing neurons in the dorsal horn of the spinal cord plays a pivotal role in the generation and maintenance of chronic neuropathic and inflammatory pain.

1 Departments of Preventive Sciences, Psychiatry, and Neuroscience and Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.
2 Molecular Neurobiology Lab (151), Veterans Affairs Medical Center, Minneapolis, MN 55417, USA.
3 Advanced Targeting Systems, 11175-A Flintkote Avenue, San Diego, CA 92121, USA.
*   To whom correspondence should be addressed. E-mail: manty001{at}maroon.tc.umn.edu

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