Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 19 November 1999:
Vol. 286. no. 5444, pp. 1555 - 1558
DOI: 10.1126/science.286.5444.1555
Prev | Table of Contents | Next

Reports

Increased Cortical Oxidative Metabolism Due to Sensory Stimulation: Implications for Functional Brain Imaging

Ivo Vanzetta, Amiram Grinvald

Modern functional brain mapping relies on interactions of neuronal electrical activity with the cortical microcirculation. The existence of a highly localized, stimulus-evoked initial deoxygenation has remained a controversy. Here, the activity-dependent oxygen tension changes in the microcirculation were measured directly, using oxygen-dependent phosphorescence quenching of an exogenous indicator. The first event after sensory stimulation was an increase in oxygen consumption, followed by an increase in blood flow. Because oxygen consumption and neuronal activity are colocalized but the delayed blood flow is not, functional magnetic resonance imaging focused on this initial phase will yield much higher spatial resolution, ultimately enabling the noninvasive visualization of fundamental processing modules in the human brain.

Department of Neurobiology, Center for Research of Higher Brain Functions, Weizmann Institute of Science, Rehovot 76100, Israel.

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Stimulus-Induced Changes in Blood Flow and 2-Deoxyglucose Uptake Dissociate in Ipsilateral Somatosensory Cortex.
A. Devor, E. M. C. Hillman, P. Tian, C. Waeber, I. C. Teng, L. Ruvinskaya, M. H. Shalinsky, H. Zhu, R. H. Haslinger, S. N. Narayanan, et al. (2008)
J. Neurosci. 28, 14347-14357
   Abstract »    Full Text »    PDF »
Lessons from fMRI about Mapping Cortical Columns.
S.-G. Kim and M. Fukuda (2008)
Neuroscientist 14, 287-299
   Abstract »    PDF »
The Triphasic Intrinsic Signal: Implications for Functional Imaging.
C. H. Chen-Bee, T. Agoncillo, Y. Xiong, and R. D. Frostig (2007)
J. Neurosci. 27, 4572-4586
   Abstract »    Full Text »    PDF »
Spatiotemporal Dynamics of the Functional Architecture for Gain Fields in Inferior Parietal Lobule of Behaving Monkey.
R. M. Siegel, J.-R. Duann, T.-P. Jung, and T. Sejnowski (2007)
Cereb Cortex 17, 378-390
   Abstract »    Full Text »    PDF »
Role of astrocytes in cerebrovascular regulation.
R. C. Koehler, D. Gebremedhin, and D. R. Harder (2006)
J Appl Physiol 100, 307-317
   Abstract »    Full Text »    PDF »
Donitriptan Decreases Jugular Venous Oxygen Saturation in Rats in the Absence of Cranial Vasoconstriction: An Overlooked Mechanism of Antimigraine Action?.
R. Letienne, J.-C. Blanchet, E. Sole, G. W. John, and B. Le Grand (2005)
J. Pharmacol. Exp. Ther. 315, 849-857
   Abstract »    Full Text »    PDF »
Localization of Activity-dependent Changes in Blood Volume to Submillimeter-scale Functional Domains in Cat Visual Cortex.
M. Fukuda, U. M. Rajagopalan, R. Homma, M. Matsumoto, M. Nishizaki, and M. Tanifuji (2005)
Cereb Cortex 15, 823-833
   Abstract »    Full Text »    PDF »
Activity-induced tissue oxygenation changes in rat cerebellar cortex: interplay of postsynaptic activation and blood flow.
N. Offenhauser, K. Thomsen, K. Caesar, and M. Lauritzen (2005)
J. Physiol. 565, 279-294
   Abstract »    Full Text »    PDF »
Compartment-Resolved Imaging of Activity-Dependent Dynamics of Cortical Blood Volume and Oximetry.
I. Vanzetta, R. Hildesheim, and A. Grinvald (2005)
J. Neurosci. 25, 2233-2244
   Abstract »    Full Text »    PDF »
Temporal Dependence in Uncoupling of Blood Volume and Oxygenation during Interictal Epileptiform Events in Rat Neocortex.
M. Suh, S. Bahar, A. D. Mehta, and T. H. Schwartz (2005)
J. Neurosci. 25, 68-77
   Abstract »    Full Text »    PDF »
Imaging primary progressive multiple sclerosis: the contribution of structural, metabolic, and functional MRI techniques.
M. Filippi, M. Rovaris, and M. A Rocca (2004)
Multiple Sclerosis 10, S36-S45
   Abstract »    PDF »
Imaging primary progressive multiple sclerosis: the contribution of structural, metabolic, and functional MRI techniques.
M. Filippi, M. Rovaris, and M. A Rocca (2004)
Multiple Sclerosis 10, S36-S45
   Abstract »    PDF »
Functional Signal- and Paradigm-Dependent Linear Relationships between Synaptic Activity and Hemodynamic Responses in Rat Somatosensory Cortex.
M. Nemoto, S. Sheth, M. Guiou, N. Pouratian, J. W. Y. Chen, and A. W. Toga (2004)
J. Neurosci. 24, 3850-3861
   Abstract »    Full Text »    PDF »
Two-photon imaging of capillary blood flow in olfactory bulb glomeruli.
E. Chaigneau, M. Oheim, E. Audinat, and S. Charpak (2003)
PNAS 100, 13081-13086
   Abstract »    Full Text »    PDF »
Dynamic imaging of somatosensory cortical activity in the rat visualized by flavoprotein autofluorescence.
K. Shibuki, R. Hishida, H. Murakami, M. Kudoh, T. Kawaguchi, M. Watanabe, S. Watanabe, T. Kouuchi, and R. Tanaka (2003)
J. Physiol. 549, 919-927
   Abstract »    Full Text »    PDF »
Imaging Spatiotemporal Dynamics of Surround Inhibition in the Barrels Somatosensory Cortex.
D. Derdikman, R. Hildesheim, E. Ahissar, A. Arieli, and A. Grinvald (2003)
J. Neurosci. 23, 3100-3105
   Abstract »    Full Text »    PDF »
Single-Neuron Activity and Tissue Oxygenation in the Cerebral Cortex.
J. K. Thompson, M. R. Peterson, and R. D. Freeman (2003)
Science 299, 1070-1072
   Abstract »    Full Text »    PDF »
Multiwavelength Optical Intrinsic Signal Imaging of Cortical Spreading Depression.
A. M. Ba, M. Guiou, N. Pouratian, A. Muthialu, D. E. Rex, A. F. Cannestra, J. W. Y. Chen, and A. W. Toga (2002)
J Neurophysiol 88, 2726-2735
   Abstract »    Full Text »    PDF »
Suppression of cortical functional hyperemia to vibrissal stimulation in the rat by epoxygenase inhibitors.
X. Peng, J. R. Carhuapoma, A. Bhardwaj, N. J. Alkayed, J. R. Falck, D. R. Harder, R. J. Traystman, and R. C. Koehler (2002)
Am J Physiol Heart Circ Physiol 283, H2029-H2037
   Abstract »    Full Text »    PDF »
Vascularization in the Primate Visual Cortex during Development.
C. Fonta and M. Imbert (2002)
Cereb Cortex 12, 199-211
   Abstract »    Full Text »    PDF »
The Cortical Representation of the Hand in Macaque and Human Area S-I: High Resolution Optical Imaging.
D. Shoham and A. Grinvald (2001)
J. Neurosci. 21, 6820-6835
   Abstract »    Full Text »    PDF »
Temporal Spatial Differences Observed by Functional MRI and Human Intraoperative Optical Imaging.
A. F. Cannestra, N. Pouratian, S. Y. Bookheimer, N. A. Martin, D. P. Becker, and A. W. Toga (2001)
Cereb Cortex 11, 773-782
   Abstract »    Full Text »    PDF »
Cognitive performance and cerebrohemodynamics associated with the Persian Gulf Syndrome.
L. Bunegin, H. C Mitzel, C. S Miller, J. F Gelineau, and G. P Tolstykh (2001)
Toxicology and Industrial Health 17, 128-137
   Abstract »    PDF »
Tuning and Topography in an Odor Map on the Rat Olfactory Bulb.
M. Meister and T. Bonhoeffer (2001)
J. Neurosci. 21, 1351-1360
   Abstract »    Full Text »    PDF »
Long-Term Optical Imaging and Spectroscopy Reveal Mechanisms Underlying the Intrinsic Signal and Stability of Cortical Maps in V1 of Behaving Monkeys.
E. Shtoyerman, A. Arieli, H. Slovin, I. Vanzetta, and A. Grinvald (2000)
J. Neurosci. 20, 8111-8121
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)