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Science 5 November 1999:
Vol. 286. no. 5442, pp. 1141 - 1146
DOI: 10.1126/science.286.5442.1141
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Reports

Similarity of the C. elegans Developmental Timing Protein LIN-42 to Circadian Rhythm Proteins

Mili Jeon, 1* Heather F. Gardner, 2* Eric A. Miller, 2dagger Jodie Deshler, 2ddagger Ann E. Rougvie 12§

The Caenorhabditis elegans heterochronic genes control the relative timing and sequence of many events during postembryonic development, including the terminal differentiation of the lateral hypodermis, which occurs during the final (fourth) molt. Inactivation of the heterochronic gene lin-42 causes hypodermal terminal differentiation to occur precociously, during the third molt. LIN-42 most closely resembles the Period family of proteins from Drosophila and other organisms, proteins that function in another type of biological timing mechanism: the timing of circadian rhythms. Per mRNA levels oscillate with an approximately 24-hour periodicity. lin-42 mRNA levels also oscillate, but with a faster rhythm; the oscillation occurs relative to the approximately 6-hour molting cycles of postembryonic development.

1 Department of Biochemistry, Molecular Biology, and Biophysics;
2 Department of Genetics, Cell Biology, and Development, University of Minnesota, St. Paul, MN 55108, USA.
*   These authors contributed equally to this work.

dagger    Present address: Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA.

ddagger    Present address: Department of Biology, University of Wisconsin, River Falls, WI 54022, USA.

§   To whom correspondence should be addressed.

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