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Science 29 October 1999:
Vol. 286. no. 5441, pp. 955 - 958
DOI: 10.1126/science.286.5441.955
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Reports

Epigenetic Inheritance of Active Chromatin After Removal of the Main Transactivator

Giacomo Cavalli, 12 Renato Paro 1*

The Drosophila Polycomb and trithorax group proteins act through chromosomal elements such as Fab-7 to maintain repressed or active gene expression, respectively. A Fab-7 element is switched from a silenced to a mitotically heritable active state by an embryonic pulse of transcription. Here, histone H4 hyperacetylation was found to be associated with Fab-7 after activation, suggesting that H4 hyperacetylation may be a heritable epigenetic tag of the activated element. Activated Fab-7 enables transcription of a gene even after withdrawal of the primary transcription factor. This feature may allow epigenetic maintenance of active states of developmental genes after decay of their early embryonic regulators.

1 Zentrum für Molekulare Biologie (ZMBH), Universität of Heidelberg, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany.
2 Institut de Génétique Humaine, 141, rue de la Cardonille, 34396 Montpellier, France.
*   To whom correspondence should be addressed. E-mail: paro{at}sun0.urz.uni-heidelberg.de

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