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Science 22 October 1999:
Vol. 286. no. 5440, pp. 689 - 690
DOI: 10.1126/science.286.5440.689
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Perspectives
Also see the archival list of Science's Compass: Enhanced Perspectives
NEUROBIOLOGY:
Enhanced: Cranking It Up a Notch
Anjen Chenn and Christopher A. Walsh
Neurons in the cerebral cortex grow by extending neurites (axons and dendrites) and making connections with their neighbors. It now transpires, as Chenn and Walsh discuss in their Perspective, that the Notch receptor and its ligands control the process of neurite extension (  estan et al.). When neurons are bunched close together and their neurites are touching each other, the Notch receptor is activated and neurites retract. But if neurons are spaced too widely apart, the Notch receptor is not activated and neurites continue to grow and extend until they connect with the neurites of their neighbors.
A. Chenn is in the Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. E-mail: shoogasmax{at}netzero.net C. A. Walsh is in the Division of Neurogenetics, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. E-mail: cwalsh{at}caregroup.harvard.edu
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Functional diversity of notch family genes in fetal lung development.
- Y. Kong, J. Glickman, M. Subramaniam, A. Shahsafaei, K. P. Allamneni, J. C. Aster, J. Sklar, and M. E. Sunday (2004)
Am J Physiol Lung Cell Mol Physiol
286, L1075-L1083
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- Repression of Activator Protein-1-mediated Transcriptional Activation by the Notch-1 Intracellular Domain.
- J. Chu, S. Jeffries, J. E. Norton, A. J. Capobianco, and E. H. Bresnick (2002)
J. Biol. Chem.
277, 7587-7597
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