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Science 24 September 1999:
Vol. 285. no. 5436, pp. 2082 - 2083
DOI: 10.1126/science.285.5436.2082
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Perspectives
CELL BIOLOGY:
All Creatures Great and Small
Sally J. Leevers
It is a mystery how multicellular organisms regulate the size of their cells and their overall mass. A number of papers, using the fruit fly Drosophila as a model system, now show that different molecules along the pathway that transduces signals from the insulin receptor and its ligand are involved in regulating cell size and growth rate. Sally Leevers ties together the findings of these different studies in an illuminating Perspective.
The author is at the Ludwig Institute for Cancer Research, 91 Riding House Street, London W1P 8BT, UK, and the Department of Biochemistry and Molecular Biology, University College, London WC1E 6BT, UK. E-mail: sallyl{at}ludwig.ucl.ac.uk
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- High-resolution dynamics of the transcriptional response to nutrition in Drosophila: a key role for dFOXO.
- B. Gershman, O. Puig, L. Hang, R. M. Peitzsch, M. Tatar, and R. S. Garofalo (2007)
Physiol Genomics
29, 24-34
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- An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice.
- K. Podsypanina, R. T. Lee, C. Politis, I. Hennessy, A. Crane, J. Puc, M. Neshat, H. Wang, L. Yang, J. Gibbons, et al. (2001)
PNAS
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- Do growth and cell division rates determine cell size in multicellular organisms?.
- C. Coelho and S. Leevers (2000)
J. Cell Sci.
113, 2927-2934
| Abstract »
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- An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice.
- K. Podsypanina, R. T. Lee, C. Politis, I. Hennessy, A. Crane, J. Puc, M. Neshat, H. Wang, L. Yang, J. Gibbons, et al. (2001)
PNAS
98, 10320-10325
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