Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 27 August 1999:
Vol. 285. no. 5432, pp. 1390 - 1393
DOI: 10.1126/science.285.5432.1390
Prev | Table of Contents | Next

Reports

Gene Expression Profile of Aging and Its Retardation by Caloric Restriction

Cheol-Koo Lee, 13 Roger G. Klopp, 2 Richard Weindruch, 4* Tomas A. Prolla 3*

The gene expression profile of the aging process was analyzed in skeletal muscle of mice. Use of high-density oligonucleotide arrays representing 6347 genes revealed that aging resulted in a differential gene expression pattern indicative of a marked stress response and lower expression of metabolic and biosynthetic genes. Most alterations were either completely or partially prevented by caloric restriction, the only intervention known to retard aging in mammals. Transcriptional patterns of calorie-restricted animals suggest that caloric restriction retards the aging process by causing a metabolic shift toward increased protein turnover and decreased macromolecular damage.

1 Environmental Toxicology Center,
2 Institute on Aging,
3 Departments of Genetics and Medical Genetics, University of Wisconsin, Madison, WI 53706, USA.
4 Department of Medicine and Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, WI and Veterans Administration Hospital, Geriatric Research, Education and Clinical Center, Madison, WI 53705, USA.
*   To whom correspondence should be addressed at Department of Medicine, VA Hospital (GRECC 4D), 2500 Overlook Terrace, Madison, WI 53705, USA. E-mail: rhweindr{at}facstaff.wisc.edu (R.W.); Departments of Genetics and Medical Genetics, 445 Henry Mall, University of Wisconsin, Madison, WI 53706, USA. E-mail: taprolla{at}facstaff.wisc.edu (T.A.P.)

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Immune and behavioral consequences of microglial reactivity in the aged brain.
A. M. Wynne, C. J. Henry, and J. P. Godbout (2009)
Integr. Comp. Biol. 49, 254-266
   Abstract »    Full Text »    PDF »
Mutations in Two Zinc-Cluster Proteins Activate Alternative Respiratory and Gluconeogenic Pathways and Restore Senescence in Long-Lived Respiratory Mutants of Podospora anserina.
C. H. Sellem, E. Bovier, S. Lorin, and A. Sainsard-Chanet (2009)
Genetics 182, 69-78
   Abstract »    Full Text »    PDF »
Downregulation of Grb2 contributes to the insulin-sensitizing effect of calorie restriction.
X. Liu, M. Liu, J. Zhang, X. Bai, F. Ramos, H. Van Remmen, A. Richardson, F.-Y. Liu, L. Q. Dong, and F. Liu (2009)
Am J Physiol Endocrinol Metab 296, E1067-E1075
   Abstract »    Full Text »    PDF »
Differential Regulation of Hepatic Heme Oxygenase-1 Protein With Aging and Heat Stress.
S. A. Bloomer, H. J. Zhang, K. E. Brown, and K. C. Kregel (2009)
J Gerontol A Biol Sci Med Sci 64A, 419-425
   Abstract »    Full Text »    PDF »
Induction of Cellular Senescence by Secretory Phospholipase A2 in Human Dermal Fibroblasts through an ROS-Mediated p53 Pathway.
H. J. Kim, K. S. Kim, S. H. Kim, S.-H. Baek, H. Y. Kim, C. Lee, and J.-R. Kim (2009)
J Gerontol A Biol Sci Med Sci
   Abstract »    Full Text »    PDF »
Caloric Restriction and Aging: Studies in Mice and Monkeys.
R. M. Anderson, D. Shanmuganayagam, and R. Weindruch (2009)
Toxicol Pathol 37, 47-51
   Abstract »    Full Text »    PDF »
How to Live Long and Prosper: Autophagy, Mitochondria, and Aging.
W.-L. Yen and D. J. Klionsky (2008)
Physiology 23, 248-262
   Abstract »    Full Text »    PDF »
Activation of NF-E2-Related Factor-2 Reverses Biochemical Dysfunction of Endothelial Cells Induced by Hyperglycemia Linked to Vascular Disease.
M. Xue, Q. Qian, A. Adaikalakoteswari, N. Rabbani, R. Babaei-Jadidi, and P. J. Thornalley (2008)
Diabetes 57, 2809-2817
   Abstract »    Full Text »    PDF »
Identification of cold-shock protein RBM3 as a possible regulator of skeletal muscle size through expression profiling.
E. E. Dupont-Versteegden, R. Nagarajan, M. L. Beggs, E. D. Bearden, P. M. Simpson, and C. A. Peterson (2008)
Am J Physiol Regulatory Integrative Comp Physiol 295, R1263-R1273
   Abstract »    Full Text »    PDF »
Necdin Regulates p53 Acetylation via Sirtuin1 to Modulate DNA Damage Response in Cortical Neurons.
K. Hasegawa and K. Yoshikawa (2008)
J. Neurosci. 28, 8772-8784
   Abstract »    Full Text »    PDF »
Gene expression profiling of human skeletal muscle in response to stabilized weight loss.
D. Larrouy, P. Barbe, C. Valle, S. Dejean, V. Pelloux, C. Thalamas, J.-P. Bastard, A. Le Bouil, B. Diquet, K. Clement, et al. (2008)
Am. J. Clinical Nutrition 88, 125-132
   Abstract »    Full Text »    PDF »
{alpha}- and {gamma}-Tocopherol Prevent Age-Related Transcriptional Alterations in the Heart and Brain of Mice.
S.-K. Park, G. P. Page, K. Kim, D. B. Allison, M. Meydani, R. Weindruch, and T. A. Prolla (2008)
J. Nutr. 138, 1010-1018
   Abstract »    Full Text »    PDF »
Role of Mitochondrial Dysfunction in Insulin Resistance.
J.-a Kim, Y. Wei, and J. R. Sowers (2008)
Circ. Res. 102, 401-414
   Abstract »    Full Text »    PDF »
Peroxisome Proliferator-Activated Receptor {alpha} Down-Regulation Is Associated With Enhanced Ceramide Levels in Age-Associated Cardiac Hypertrophy.
R. Rodriguez-Calvo, L. Serrano, E. Barroso, T. Coll, X. Palomer, A. Camins, R. M. Sanchez, M. Alegret, M. Merlos, M. Pallas, et al. (2007)
J. Gerontol. A Biol. Sci. Med. Sci. 62, 1326-1336
   Abstract »    Full Text »    PDF »
Increased TNF{alpha} and CCAAT/enhancer-binding protein homologous protein with aging predispose preadipocytes to resist adipogenesis.
T. Tchkonia, T. Pirtskhalava, T. Thomou, M. J. Cartwright, B. Wise, I. Karagiannides, A. Shpilman, T. L. Lash, J. D. Becherer, and J. L. Kirkland (2007)
Am J Physiol Endocrinol Metab 293, E1810-E1819
   Abstract »    Full Text »    PDF »
Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes.
V. Misra, H. Lee, A. Singh, K. Huang, R. K. Thimmulappa, W. Mitzner, S. Biswal, and C. G. Tankersley (2007)
Physiol Genomics 31, 429-440
   Abstract »    Full Text »    PDF »
VEGF-R blockade causes endothelial cell apoptosis, expansion of surviving CD34+ precursor cells and transdifferentiation to smooth muscle-like and neuronal-like cells.
S. Sakao, L. Taraseviciene-Stewart, C. D. Cool, Y. Tada, Y. Kasahara, K. Kurosu, N. Tanabe, Y. Takiguchi, K. Tatsumi, T. Kuriyama, et al. (2007)
FASEB J 21, 3640-3652
   Abstract »    Full Text »    PDF »
Fatty acid desaturase regulation in adipose tissue by dietary composition is independent of weight loss and is correlated with the plasma triacylglycerol response.
L. M Mangravite, K. Dawson, R. R Davis, J. P Gregg, and R. M Krauss (2007)
Am. J. Clinical Nutrition 86, 759-767
   Abstract »    Full Text »    PDF »
The Mammalian Target of Rapamycin Pathway as a Potential Target for Cancer Chemoprevention.
L. Kopelovich, J. R. Fay, C. C. Sigman, and J. A. Crowell (2007)
Cancer Epidemiol. Biomarkers Prev. 16, 1330-1340
   Abstract »    Full Text »    PDF »
Inadequate protein intake affects skeletal muscle transcript profiles in older humans.
A. E Thalacker-Mercer, J. C Fleet, B. A Craig, N. S Carnell, and W. W Campbell (2007)
Am. J. Clinical Nutrition 85, 1344-1352
   Abstract »    Full Text »    PDF »
Oxidative Stress, Mitochondrial DNA Mutation, and Apoptosis in Aging.
H.-C. Lee and Y.-H. Wei (2007)
Experimental Biology and Medicine 232, 592-606
   Abstract »    Full Text »    PDF »
Different Gene Expression of Skin Tissues Between Mice with Weight Controlled by Either Calorie Restriction or Physical Exercise.
J. Lu, L. Xie, J. Sylvester, J. Wang, J. Bai, R. Baybutt, and W. Wang (2007)
Experimental Biology and Medicine 232, 473-480
   Abstract »    Full Text »    PDF »
Generation of Inhibitory NF{kappa}B Complexes and Phosphorylated cAMP Response Element-binding Protein Correlates with the Anti-inflammatory Activity of Complement Protein C1q in Human Monocytes.
D. A. Fraser, M. Arora, S. S. Bohlson, E. Lozano, and A. J. Tenner (2007)
J. Biol. Chem. 282, 7360-7367
   Abstract »    Full Text »    PDF »
Effect of Aging and Caloric Restriction on the Mitochondrial Proteome.
J. Chang, J. E. Cornell, H. Van Remmen, K. Hakala, W. F. Ward, and A. Richardson (2007)
J. Gerontol. A Biol. Sci. Med. Sci. 62, 223-234
   Abstract »    Full Text »    PDF »
An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations.
K. C. Kregel and H. J. Zhang (2007)
Am J Physiol Regulatory Integrative Comp Physiol 292, R18-R36
   Abstract »    Full Text »    PDF »
Synergistic effects of caloric restriction with maintained protein intake on skeletal muscle performance in 21-month-old rats: a mitochondria-mediated pathway.
A. Zangarelli, E. Chanseaume, B. Morio, C. Brugere, L. Mosoni, P. Rousset, C. Giraudet, V. Patrac, P. Gachon, Y. Boirie, et al. (2006)
FASEB J 20, 2439-2450
   Abstract »    Full Text »    PDF »
LONGEVITY REGULATION AND AGING IN ANIMAL MODELS.
H. R. Warner (2006)
Gerontologist 46, 844-847
   Full Text »    PDF »
Gene expression profiling of bovine skeletal muscle in response to and during recovery from chronic and severe undernutrition.
S. A. Lehnert, K. A. Byrne, A. Reverter, G. S. Nattrass, P. L. Greenwood, Y. H. Wang, N. J. Hudson, and G. S. Harper (2006)
J Anim Sci 84, 3239-3250
   Abstract »    Full Text »    PDF »
The use of transcriptional profiles to predict adult mosquito age under field conditions.
P. E. Cook, L. E. Hugo, I. Iturbe-Ormaetxe, C. R. Williams, S. F. Chenoweth, S. A. Ritchie, P. A. Ryan, B. H. Kay, M. W. Blows, and S. L. O'Neill (2006)
PNAS 103, 18060-18065
   Abstract »    Full Text »    PDF »
Coordinated multitissue transcriptional and plasma metabonomic profiles following acute caloric restriction in mice.
C. Selman, N. D. Kerrison, A. Cooray, M. D. W. Piper, S. J. Lingard, R. H. Barton, E. F. Schuster, E. Blanc, D. Gems, J. K. Nicholson, et al. (2006)
Physiol Genomics 27, 187-200
   Abstract »    Full Text »    PDF »
Growth Regulation via Insulin-Like Growth Factor Binding Protein-4 and -2 in Association with Mutant K-ras in Lung Epithelia.
H. Sato, T. Yazawa, T. Suzuki, H. Shimoyamada, K. Okudela, M. Ikeda, K. Hamada, H. Yamada-Okabe, M. Yao, Y. Kubota, et al. (2006)
Am. J. Pathol. 169, 1550-1566
   Abstract »    Full Text »    PDF »
Of mice and monkeys: national institute on aging resources supporting the use of animal models in biogerontology research..
N. L. Nadon (2006)
J. Gerontol. A Biol. Sci. Med. Sci. 61, 813-815
   Abstract »    Full Text »    PDF »
High-Resolution Mapping of Quantitative Trait Loci Affecting Increased Life Span in Drosophila melanogaster.
R. H. Wilson, T. J. Morgan, and T. F. C. Mackay (2006)
Genetics 173, 1455-1463
   Abstract »    Full Text »    PDF »
Effect of 6-Month Calorie Restriction on Biomarkers of Longevity, Metabolic Adaptation, and Oxidative Stress in Overweight Individuals: A Randomized Controlled Trial.
L. K. Heilbronn, L. de Jonge, M. I. Frisard, J. P. DeLany, D. E. Larson-Meyer, J. Rood, T. Nguyen, C. K. Martin, J. Volaufova, M. M. Most, et al. (2006)
JAMA 295, 1539-1548
   Abstract »    Full Text »    PDF »
The effect of aging on anaerobic and aerobic enzyme activities in human skeletal muscle..
J. J. Kaczor, W. Ziolkowski, J. Antosiewicz, S. Hac, M. A. Tarnopolsky, and J. Popinigis (2006)
J. Gerontol. A Biol. Sci. Med. Sci. 61, 339-344
   Abstract »    Full Text »    PDF »
A perspective on sporadic inclusion-body myositis: The role of aging and inflammatory processes.
C. E. Finch (2006)
Neurology 66, S1-S6
   Abstract »    Full Text »    PDF »
Oxidative stress and ageing: is ageing a cysteine deficiency syndrome?.
W. Droge (2005)
Phil Trans R Soc B 360, 2355-2372
   Abstract »    Full Text »    PDF »
Peroxisome Proliferator-Activated Receptor {gamma} Coactivator 1 in Caloric Restriction and Other Models of Longevity.
J. C. Corton and H. M. Brown-Borg (2005)
J. Gerontol. A Biol. Sci. Med. Sci. 60, 1494-1509
   Abstract »    Full Text »    PDF »
Oxidative Aging and Insulin Receptor Signaling.
W. Droge (2005)
J. Gerontol. A Biol. Sci. Med. Sci. 60, 1378-1385
   Abstract »    Full Text »    PDF »
Angiotensin-Converting Enzyme Inhibition Intervention in Elderly Persons: Effects on Body Composition and Physical Performance.
C. S. Carter, G. Onder, S. B. Kritchevsky, and M. Pahor (2005)
J. Gerontol. A Biol. Sci. Med. Sci. 60, 1437-1446
   Abstract »    Full Text »    PDF »
Anemia in the Elderly: Time for New Blood in Old Vessels?.
J. L. Spivak (2005)
Arch Intern Med 165, 2187-2189
   Full Text »    PDF »
Diabesity: A Polygenic Model of Dietary-Induced Obesity from Ad Libitum Overfeeding of Sprague-Dawley Rats and Its Modulation by Moderate and Marked Dietary Restriction.
K. P. Keenan, C.-M. Hoe, L. Mixson, C. L. Mccoy, J. B. Coleman, B. A. Mattson, G. A. Ballam, L. A. Gumprecht, and K. A. Soper (2005)
Toxicol Pathol 33, 650-674
   Abstract »    Full Text »    PDF »
Caloric Restriction Results in Decreased Expression of Peroxisome Proliferator-Activated Receptor Superfamily in Muscle of Normal and Long-Lived Growth Hormone Receptor/Binding Protein Knockout Mice.
M. M. Masternak, K. A. Al-Regaiey, M. M. Del Rosario Lim, M. S. Bonkowski, J. A. Panici, G. K. Przybylski, and A. Bartke (2005)
J. Gerontol. A Biol. Sci. Med. Sci. 60, 1238-1245
   Abstract »    Full Text »    PDF »
Minireview: The Role of Oxidative Stress in Relation to Caloric Restriction and Longevity.
R. Gredilla and G. Barja (2005)
Endocrinology 146, 3713-3717
   Abstract »    Full Text »    PDF »
Differential patterns of apoptosis in response to aging in Drosophila.
J. Zheng, S. W. Edelman, G. Tharmarajah, D. W. Walker, S. D. Pletcher, and L. Seroude (2005)
PNAS 102, 12083-12088
   Abstract »    Full Text »    PDF »
Advanced glycation endproduct-induced aging of the retinal pigment epithelium and choroid: A comprehensive transcriptional response.
J. Tian, K. Ishibashi, K. Ishibashi, K. Reiser, R. Grebe, S. Biswal, P. Gehlbach, and J. T. Handa (2005)
PNAS 102, 11846-11851
   Abstract »    Full Text »    PDF »
Gene expression evidence for remodeling of lateral hypothalamic circuitry in cocaine addiction.
S. H. Ahmed, R. Lutjens, L. D. van der Stap, D. Lekic, V. Romano-Spica, M. Morales, G. F. Koob, V. Repunte-Canonigo, and P. P. Sanna (2005)
PNAS 102, 11533-11538
   Abstract »    Full Text »    PDF »
Cell intrinsic alterations underlie hematopoietic stem cell aging.
D. J. Rossi, D. Bryder, J. M. Zahn, H. Ahlenius, R. Sonu, A. J. Wagers, and I. L. Weissman (2005)
PNAS 102, 9194-9199
   Abstract »    Full Text »    PDF »
Microarray Evaluation of Dietary Restriction.
E.-S. Han and M. Hickey (2005)
J. Nutr. 135, 1343-1346
   Abstract »    Full Text »    PDF »
Circadian profiling of the transcriptome in immortalized rat SCN cells.
G. J. Menger, K. Lu, T. Thomas, V. M. Cassone, and D. J. Earnest (2005)
Physiol Genomics 21, 370-381
   Abstract »    Full Text »    PDF »
Aging and biomedicine 2005: Where should we go from here?.
M. Barton (2005)
Cardiovasc Res 66, 187-189
   Full Text »    PDF »
Gene expression profiling studies of aging in cardiac and skeletal muscles.
S.-K. Park and T. A. Prolla (2005)
Cardiovasc Res 66, 205-212
   Abstract »    Full Text »    PDF »
Identification of a molecular signature of sarcopenia.
P. G. Giresi, E. J. Stevenson, J. Theilhaber, A. Koncarevic, J. Parkington, R. A. Fielding, and S. C. Kandarian (2005)
Physiol Genomics 21, 253-263
   Abstract »    Full Text »    PDF »
Brief Food Restriction in Old Animals Decreases Triglyceride Content and Insulin-Stimulated Triglyceride Synthesis.
M. Z. Tucker and L. P. Turcotte (2005)
J. Gerontol. A Biol. Sci. Med. Sci. 60, 157-164
   Abstract »    Full Text »    PDF »
Alternate-day fasting in nonobese subjects: effects on body weight, body composition, and energy metabolism.
L. K Heilbronn, S. R Smith, C. K Martin, S. D Anton, and E. Ravussin (2005)
Am. J. Clinical Nutrition 81, 69-73
   Abstract »    Full Text »    PDF »
The Glomerulosclerosis of Aging in Females: Contribution of the Proinflammatory Mesangial Cell Phenotype to Macrophage Infiltration.
F. Zheng, Q.-L. Cheng, A.-R. Plati, S. Q. Ye, M. Berho, A. Banerjee, M. Potier, E. A. Jaimes, H. Yu, Y.-F. Guan, et al. (2004)
Am. J. Pathol. 165, 1789-1798
   Abstract »    Full Text »    PDF »
Hepatic Genes Altered in Expression by Food Restriction Are Not Influenced by the Low Plasma Glucose Level in Young Male GLUT4 Transgenic Mice.
C. Fu, L. Xi, Y. Wu, R. McCarter, A. Richardson, M. Hickey, and E.-S. Han (2004)
J. Nutr. 134, 2965-2974
   Abstract »    Full Text »    PDF »
Microarrays as a Tool to Investigate the Biology of Aging: A Retrospective and a Look to the Future.
S. Melov and A. Hubbard (2004)
Sci. Aging Knowl. Environ. 2004, re7
   Abstract »    Full Text »    PDF »
Age-associated alteration of gene expression patterns in mouse oocytes.
T. Hamatani, G. Falco, M. G. Carter, H. Akutsu, C. A. Stagg, A. A. Sharov, D. B. Dudekula, V. VanBuren, and M. S.H. Ko (2004)
Hum. Mol. Genet. 13, 2263-2278
   Abstract »    Full Text »    PDF »
Restriction of Dietary Energy and Protein Induces Molecular Changes in Young Porcine Skeletal Muscles.
N. da Costa, C. McGillivray, Q. Bai, J. D. Wood, G. Evans, and K.-C. Chang (2004)
J. Nutr. 134, 2191-2199
   Abstract »    Full Text »    PDF »
Identification of genes contributing to the obese yellow Avy phenotype: caloric restriction, genotype, diet x genotype interactions.
J. Kaput, K. G. Klein, E. J. Reyes, W. A. Kibbe, C. A. Cooney, B. Jovanovic, W. J. Visek, and G. L. Wolff (2004)
Physiol Genomics 18, 316-324
   Abstract »    Full Text »    PDF »
Power and sample size estimation in high dimensional biology.
G. L Gadbury, G. P Page, J. Edwards, T. Kayo, T. A Prolla, R. Weindruch, P. A Permana, J. D Mountz, and D. B Allison (2004)
Statistical Methods in Medical Research 13, 325-338
   Abstract »    PDF »
How Much Should We Eat? The Association Between Energy Intake and Mortality in a 36-Year Follow-Up Study of Japanese-American Men.
B. J. Willcox, K. Yano, R. Chen, D. C. Willcox, B. L. Rodriguez, K. H. Masaki, T. Donlon, B. Tanaka, and J. D. Curb (2004)
J. Gerontol. A Biol. Sci. Med. Sci. 59, B789-B795
   Abstract »    Full Text »    PDF »
Gene expression analysis suggests that 1,25-dihydroxyvitamin D3 reverses experimental autoimmune encephalomyelitis by stimulating inflammatory cell apoptosis.
K. M. Spach, L. B. Pedersen, F. E. Nashold, T. Kayo, B. S. Yandell, T. A. Prolla, and C. E. Hayes (2004)
Physiol Genomics 18, 141-151
   Abstract »    Full Text »    PDF »
Aging: The Reality: Biomarkers of Aging: From Primitive Organisms to Humans.
R. N. Butler, R. Sprott, H. Warner, J. Bland, R. Feuers, M. Forster, H. Fillit, S. M. Harman, M. Hewitt, M. Hyman, et al. (2004)
J. Gerontol. A Biol. Sci. Med. Sci. 59, B560-B567
   Abstract »    Full Text »    PDF »
Similar gene expression patterns characterize aging and oxidative stress in Drosophila melanogaster.
G. N. Landis, D. Abdueva, D. Skvortsov, J. Yang, B. E. Rabin, J. Carrick, S. Tavare, and J. Tower (2004)
PNAS 101, 7663-7668
   Abstract »    Full Text »    PDF »
Angiotensin-Converting Enzyme Inhibition, Body Composition, and Physical Performance in Aged Rats.
C. S. Carter, M. Cesari, W. T. Ambrosius, N. Hu, D. Diz, S. Oden, W. E. Sonntag, and M. Pahor (2004)
J. Gerontol. A Biol. Sci. Med. Sci. 59, B416-B423
   Abstract »    Full Text »    PDF »
Many Roads to Ruin.
M. Leslie (2004)
Sci. Aging Knowl. Environ. 2004, ns2
   Abstract »    Full Text »    PDF »
Gas1 is induced by VE-cadherin and vascular endothelial growth factor and inhibits endothelial cell apoptosis.
R. Spagnuolo, M. Corada, F. Orsenigo, L. Zanetta, U. Deuschle, P. Sandy, C. Schneider, C. J. Drake, F. Breviario, and E. Dejana (2004)
Blood 103, 3005-3012
   Abstract »    Full Text »    PDF »
Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: a randomized controlled clinical trial.
B. J Nicklas, W. Ambrosius, S. P Messier, G. D Miller, B. W. Penninx, R. F Loeser, S. Palla, E. Bleecker, and M. Pahor (2004)
Am. J. Clinical Nutrition 79, 544-551
   Abstract »    Full Text »    PDF »
Quantitative Trait Loci Specifying the Response of Body Temperature to Dietary Restriction.
B. A. Rikke, J. E. Yerg III, M. E. Battaglia, T. R. Nagy, D. B. Allison, and T. E. Johnson (2004)
J. Gerontol. A Biol. Sci. Med. Sci. 59, B118-125
   Abstract »    Full Text »    PDF »
Short-term CR decreases cardiac mitochondrial oxidant production but increases carbonyl content.
S. Judge, A. Judge, T. Grune, and C. Leeuwenburgh (2004)
Am J Physiol Regulatory Integrative Comp Physiol 286, R254-R259
   Abstract »    Full Text »    PDF »
Nutritional genomics: the next frontier in the postgenomic era.
J. Kaput and R. L. Rodriguez (2004)
Physiol Genomics 16, 166-177
   Abstract »    Full Text »    PDF »
Growth hormone-mediated alteration of fuel metabolism in the aged rat as determined from transcript profiles.
P. Tollet-Egnell, P. Parini, N. Stahlberg, I. Lonnstedt, N. H. Lee, M. Rudling, A. Flores-Morales, and G. Norstedt (2004)
Physiol Genomics 16, 261-267
   Abstract »    Full Text »    PDF »
Linkage between insulin and the free radical theory of aging.
D. Julian and C. Leeuwenburgh (2004)
Am J Physiol Regulatory Integrative Comp Physiol 286, R20-R21
   Full Text »    PDF »
A definition of internal constancy and homeostasis in the context of non-equilibrium thermodynamics.
G. Recordati and T. G. Bellini (2004)
Exp Physiol 89, 27-38
   Abstract »    Full Text »    PDF »
Age-related changes in the transcriptional profile of mouse RPE/choroid.
H. Ida, S. A. Boylan, A. L. Weigel, and L. M. Hjelmeland (2003)
Physiol Genomics 15, 258-262
   Abstract »    Full Text »    PDF »
Solution Structure of the 162 Residue C-terminal Domain of Human Elongation Factor 1B{gamma}.
S. Vanwetswinkel, J. Kriek, G. R. Andersen, P. Guntert, J. Dijk, G. W. Canters, and G. Siegal (2003)
J. Biol. Chem. 278, 43443-43451
   Abstract »    Full Text »    PDF »
Gene expression profiling in Werner syndrome closely resembles that of normal aging.
K. J. Kyng, A. May, S. Kolvraa, and V. A. Bohr (2003)
PNAS 100, 12259-12264
   Abstract »    Full Text »    PDF »
Invited Review: Theories of aging.
B. T. Weinert and P. S. Timiras (2003)
J Appl Physiol 95, 1706-1716
   Abstract »    Full Text »    PDF »
Nutritional Genomics: Implications for Companion Animals.
K. S. Swanson, L. B. Schook, and G. C. Fahey Jr. (2003)
J. Nutr. 133, 3033-3040
   Abstract »    Full Text »    PDF »
Gene expression profiles and protein balance in skeletal muscle of burned children after {beta}-adrenergic blockade.
D. N. Herndon, M. R. K. Dasu, R. R. Wolfe, and R. E. Barrow (2003)
Am J Physiol Endocrinol Metab 285, E783-E789
   Abstract »    Full Text »    PDF »
Transcriptional profiling identifies extensive downregulation of extracellular matrix gene expression in sarcopenic rat soleus muscle.
J. S. Pattison, L. C. Folk, R. W. Madsen, T. E. Childs, and F. W. Booth (2003)
Physiol Genomics 15, 34-43
   Abstract »    Full Text »    PDF »
Cytokine Milieu of Atopic Dermatitis, as Compared to Psoriasis, Skin Prevents Induction of Innate Immune Response Genes.
I. Nomura, E. Goleva, M. D. Howell, Q. A. Hamid, P. Y. Ong, C. F. Hall, M. A. Darst, B. Gao, M. Boguniewicz, J. B. Travers, et al. (2003)
J. Immunol. 171, 3262-3269
   Abstract »    Full Text »    PDF »
Understanding the Determinants of Exceptional Longevity.
T. Perls and D. Terry (2003)
Ann Intern Med 139, 445-449
   Abstract »    Full Text »    PDF »
Calorie restriction and aging: review of the literature and implications for studies in humans.
L. K Heilbronn and E. Ravussin (2003)
Am. J. Clinical Nutrition 78, 361-369
   Abstract »    Full Text »    PDF »
Ubiquitin, Proteasomes, and the Aging Brain.
D. A. Gray, M. Tsirigotis, and J. Woulfe (2003)
Sci. Aging Knowl. Environ. 2003, re6-6
   Abstract »    Full Text »    PDF »
Chronic Mild Hypoxia Protects Heart-derived H9c2 Cells against Acute Hypoxia/Reoxygenation by Regulating Expression of the SUR2A Subunit of the ATP-sensitive K+ Channel.
R. M. Crawford, S. Jovanovic, G. R. Budas, A. M. Davies, H. Lad, R. H. Wenger, K. A. Robertson, D. J. Roy, H. J. Ranki, and A. Jovanovic (2003)
J. Biol. Chem. 278, 31444-31455
   Abstract »    Full Text »    PDF »
Alterations of gene expression in failing myocardium following left ventricular assist device support.
Y. Chen, S. Park, Y. Li, E. Missov, M. Hou, X. Han, J. L. Hall, L. W. Miller, and R. J. Bache (2003)
Physiol Genomics 14, 251-260
   Abstract »    Full Text »    PDF »
Central Role of the Proteasome in Senescence and Survival of Human Fibroblasts: INDUCTION OF A SENESCENCE-LIKE PHENOTYPE UPON ITS INHIBITION AND RESISTANCE TO STRESS UPON ITS ACTIVATION.
N. Chondrogianni, F. L. L. Stratford, I. P. Trougakos, B. Friguet, A. J. Rivett, and E. S. Gonos (2003)
J. Biol. Chem. 278, 28026-28037
   Abstract »    Full Text »    PDF »
Gene expression profile of aging in human muscle.
S. Welle, A. I. Brooks, J. M. Delehanty, N. Needler, and C. A. Thornton (2003)
Physiol Genomics 14, 149-159
   Abstract »    Full Text »    PDF »
Evaluation of the Effects of the Dietary Intake of Proteins and Amino Acids by DNA Microarray Technology.
H. Kato and T. Kimura (2003)
J. Nutr. 133, 2073S-2077
   Abstract »    Full Text »    PDF »
Nutritional Modulation of Gene Expression and Homocysteine Utilization by Vitamin B12.
S. Oltean and R. Banerjee (2003)
J. Biol. Chem. 278, 20778-20784
   Abstract »    Full Text »    PDF »
Age-related impairment of the transcriptional responses to oxidative stress in the mouse heart.
M. G. Edwards, D. Sarkar, R. Klopp, J. D. Morrow, R. Weindruch, and T. A. Prolla (2003)
Physiol Genomics 13, 119-127
   Abstract »    Full Text »    PDF »
Patterns of global gene expression in rat skeletal muscle during unloading and low-intensity ambulatory activity.
L. Bey, N. Akunuri, P. Zhao, E. P. Hoffman, D. G. Hamilton, and M. T. Hamilton (2003)
Physiol Genomics 13, 157-167
   Abstract »    Full Text »    PDF »
Role of the Arabidopsis Glucose Sensor HXK1 in Nutrient, Light, and Hormonal Signaling.
B. Moore, L. Zhou, F. Rolland, Q. Hall, W.-H. Cheng, Y.-X. Liu, I. Hwang, T. Jones, and J. Sheen (2003)
Science 300, 332-336
   Abstract »    Full Text »    PDF »
daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway.
W. Li, S. G. Kennedy, and G. Ruvkun (2003)
Genes & Dev. 17, 844-858
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)