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Science 30 July 1999:
Vol. 285. no. 5428, pp. 751 - 753
DOI: 10.1126/science.285.5428.751
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Reports

Detecting Protein Function and Protein-Protein Interactions from Genome Sequences

Edward M. Marcotte, Matteo Pellegrini, Ho-Leung Ng, Danny W. Rice, Todd O. Yeates, David Eisenberg *

A computational method is proposed for inferring protein interactions from genome sequences on the basis of the observation that some pairs of interacting proteins have homologs in another organism fused into a single protein chain. Searching sequences from many genomes revealed 6809 such putative protein-protein interactions in Escherichia coli and 45,502 in yeast. Many members of these pairs were confirmed as functionally related; computational filtering further enriches for interactions. Some proteins have links to several other proteins; these coupled links appear to represent functional interactions such as complexes or pathways. Experimentally confirmed interacting pairs are documented in a Database of Interacting Proteins.

UCLA-Department of Energy Laboratory of Structural Biology and Molecular Medicine, Departments of Chemistry and Biochemistry and Biological Chemistry, Box 951570, University of California at Los Angeles, Los Angeles, CA 90095-1570, USA.
*   To whom correspondence should be addressed: E-mail: david{at}mbi.ucla.edu

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