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Science 30 July 1999:
Vol. 285. no. 5428, pp. 727 - 729
DOI: 10.1126/science.285.5428.727
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Reports

Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA

Stefan Bauer, 1*dagger Veronika Groh, 1* Jun Wu, 2 Alexander Steinle, 1 Joseph H. Phillips, 2 Lewis L. Lanier, 2 Thomas Spies 1ddagger

Stress-inducible MICA, a distant homolog of major histocompatibility complex (MHC) class I, functions as an antigen for gamma delta T cells and is frequently expressed in epithelial tumors. A receptor for MICA was detected on most gamma delta T cells, CD8+ alpha beta T cells, and natural killer (NK) cells and was identified as NKG2D. Effector cells from all these subsets could be stimulated by ligation of NKG2D. Engagement of NKG2D activated cytolytic responses of gamma delta T cells and NK cells against transfectants and epithelial tumor cells expressing MICA. These results define an activating immunoreceptor-MHC ligand interaction that may promote antitumor NK and T cell responses.

1 Fred Hutchinson Cancer Research Center, Clinical Research Division, 1100 Fairview Avenue North, Seattle, WA 98109, USA.
2 DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA.
*   These authors contributed equally to this work and are listed in alphabetical order.

dagger    Present address: Technical University of Munich, Institute of Microbiology, Trogerstrasse 32, D-81675 Munich, Germany.

ddagger    To whom correspondence should be addressed. E-mail: tspies{at}fred.fhcrc.org

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S. Malarkannan, J. Regunathan, H. Chu, S. Kutlesa, Y. Chen, H. Zeng, R. Wen, and D. Wang (2007)
J. Immunol. 179, 3752-3762
   Abstract »    Full Text »    PDF »
DAP10 Deficiency Breaks the Immune Tolerance against Transplantable Syngeneic Melanoma.
N. Hyka-Nouspikel, L. Lucian, E. Murphy, T. McClanahan, and J. H. Phillips (2007)
J. Immunol. 179, 3763-3771
   Abstract »    Full Text »    PDF »
Transforming Growth Factor-{beta} and the Immune Response: Implications for Anticancer Therapy.
S. H. Wrzesinski, Y. Y. Wan, and R. A. Flavell (2007)
Clin. Cancer Res. 13, 5262-5270
   Abstract »    Full Text »    PDF »
Natural Killer Cells in Perinatally HIV-1-Infected Children Exhibit Less Degranulation Compared to HIV-1-Exposed Uninfected Children and Their Expression of KIR2DL3, NKG2C, and NKp46 Correlates with Disease Severity.
W. M. Ballan, B.-A. N. Vu, B. R. Long, C. P. Loo, J. Michaelsson, J. D. Barbour, L. L. Lanier, A. A. Wiznia, J. Abadi, G. J. Fennelly, et al. (2007)
J. Immunol. 179, 3362-3370
   Abstract »    Full Text »    PDF »
The unexpected effect of cyclosporin A on CD56+CD16 and CD56+CD16+ natural killer cell subpopulations.
H. Wang, B. Grzywacz, D. Sukovich, V. McCullar, Q. Cao, A. B. Lee, B. R. Blazar, D. N. Cornfield, J. S. Miller, and M. R. Verneris (2007)
Blood 110, 1530-1539
   Abstract »    Full Text »    PDF »
HIV modulates the expression of ligands important in triggering natural killer cell cytotoxic responses on infected primary T-cell blasts.
J. Ward, M. Bonaparte, J. Sacks, J. Guterman, M. Fogli, D. Mavilio, and E. Barker (2007)
Blood 110, 1207-1214
   Abstract »    Full Text »    PDF »


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