Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Applied Biosystems Solid

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 30 July 1999:
Vol. 285. no. 5428, pp. 727 - 729
DOI: 10.1126/science.285.5428.727
Prev | Table of Contents | Next

Reports

Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA

Stefan Bauer, 1*dagger Veronika Groh, 1* Jun Wu, 2 Alexander Steinle, 1 Joseph H. Phillips, 2 Lewis L. Lanier, 2 Thomas Spies 1ddagger

Stress-inducible MICA, a distant homolog of major histocompatibility complex (MHC) class I, functions as an antigen for gamma delta T cells and is frequently expressed in epithelial tumors. A receptor for MICA was detected on most gamma delta T cells, CD8+ alpha beta T cells, and natural killer (NK) cells and was identified as NKG2D. Effector cells from all these subsets could be stimulated by ligation of NKG2D. Engagement of NKG2D activated cytolytic responses of gamma delta T cells and NK cells against transfectants and epithelial tumor cells expressing MICA. These results define an activating immunoreceptor-MHC ligand interaction that may promote antitumor NK and T cell responses.

1 Fred Hutchinson Cancer Research Center, Clinical Research Division, 1100 Fairview Avenue North, Seattle, WA 98109, USA.
2 DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA.
*   These authors contributed equally to this work and are listed in alphabetical order.

dagger    Present address: Technical University of Munich, Institute of Microbiology, Trogerstrasse 32, D-81675 Munich, Germany.

ddagger    To whom correspondence should be addressed. E-mail: tspies{at}fred.fhcrc.org

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Adenovirus E3/19K Promotes Evasion of NK Cell Recognition by Intracellular Sequestration of the NKG2D Ligands Major Histocompatibility Complex Class I Chain-Related Proteins A and B.
B. P. McSharry, H.-G. Burgert, D. P. Owen, R. J. Stanton, V. Prod'homme, M. Sester, K. Koebernick, V. Groh, T. Spies, S. Cox, et al. (2008)
J. Virol. 82, 4585-4594
   Abstract »    Full Text »    PDF »
KIR2DS1-mediated activation overrides NKG2A-mediated inhibition in HLA-C C2-negative individuals.
B. Foley, D. De Santis, L. Lathbury, F. Christiansen, and C. Witt (2008)
Int. Immunol. 20, 555-563
   Abstract »    Full Text »    PDF »
Methylprednisolone induces preferential and rapid differentiation of CD34+ cord blood precursors toward NK cells.
C. Vitale, F. Cottalasso, E. Montaldo, L. Moretta, and M. C. Mingari (2008)
Int. Immunol. 20, 565-575
   Abstract »    Full Text »    PDF »
Evidence for Differential Roles for NKG2D Receptor Signaling in Innate Host Defense against Coronavirus-Induced Neurological and Liver Disease.
K. B. Walsh, M. B. Lodoen, R. A. Edwards, L. L. Lanier, and T. E. Lane (2008)
J. Virol. 82, 3021-3030
   Abstract »    Full Text »    PDF »
CD27 Defines Phenotypically and Functionally Different Human NK Cell Subsets.
M. T. M. Vossen, M. Matmati, K. M. L. Hertoghs, P. A. Baars, M.-R. Gent, G. Leclercq, J. Hamann, T. W. Kuijpers, and R. A. W. van Lier (2008)
J. Immunol. 180, 3739-3745
   Abstract »    Full Text »    PDF »
Capitalizing on the Immunogenicity of Dying Tumor Cells.
C. Fonseca and G. Dranoff (2008)
Clin. Cancer Res. 14, 1603-1608
   Abstract »    Full Text »    PDF »
Selective Induction of Expression of a Ligand for the NKG2D Receptor by Proteasome Inhibitors.
M. Vales-Gomez, S. E. Chisholm, R. L. Cassady-Cain, P. Roda-Navarro, and H. T. Reyburn (2008)
Cancer Res. 68, 1546-1554
   Abstract »    Full Text »    PDF »
Copulsing tumor antigen-pulsed dendritic cells with zoledronate efficiently enhance the expansion of tumor antigen-specific CD8+ T cells via V{gamma}9{gamma}{delta} T cell activation.
M. Takahara, M. Miyai, M. Tomiyama, M. Mutou, A. J. Nicol, and M. Nieda (2008)
J. Leukoc. Biol. 83, 742-754
   Abstract »    Full Text »    PDF »
JNK MAP kinase activation is required for MTOC and granule polarization in NKG2D-mediated NK cell cytotoxicity.
C. Li, B. Ge, M. Nicotra, J. N. H. Stern, H. D. Kopcow, X. Chen, and J. L. Strominger (2008)
PNAS 105, 3017-3022
   Abstract »    Full Text »    PDF »
Intrinsic sensor of oncogenic transformation induces a signal for innate immunosurveillance.
A. M. Unni, T. Bondar, and R. Medzhitov (2008)
PNAS 105, 1686-1691
   Abstract »    Full Text »    PDF »
Two Novel NKG2D Ligands of the Mouse H60 Family with Differential Expression Patterns and Binding Affinities to NKG2D.
A. Takada, S. Yoshida, M. Kajikawa, Y. Miyatake, U. Tomaru, M. Sakai, H. Chiba, K. Maenaka, D. Kohda, K. Fugo, et al. (2008)
J. Immunol. 180, 1678-1685
   Abstract »    Full Text »    PDF »
NKG2D ligand expression in AML increases in response to HDAC inhibitor valproic acid and contributes to allorecognition by NK-cell lines with single KIR-HLA class I specificities.
S. Diermayr, H. Himmelreich, B. Durovic, A. Mathys-Schneeberger, U. Siegler, U. Langenkamp, J. Hofsteenge, A. Gratwohl, A. Tichelli, M. Paluszewska, et al. (2008)
Blood 111, 1428-1436
   Abstract »    Full Text »    PDF »
4-1BB regulates NKG2D costimulation in human cord blood CD8+ T cells.
Y.-J. Kim, M.-K. Han, and H. E. Broxmeyer (2008)
Blood 111, 1378-1386
   Abstract »    Full Text »    PDF »
MHC class I chain-related protein A antibodies and shedding are associated with the progression of multiple myeloma.
M. Jinushi, M. Vanneman, N. C. Munshi, Y.-T. Tai, R. H. Prabhala, J. Ritz, D. Neuberg, K. C. Anderson, D. R. Carrasco, and G. Dranoff (2008)
PNAS 105, 1285-1290
   Abstract »    Full Text »    PDF »
Profiling killers; unravelling the pathways of human natural killer cell function.
G. B. Scott, J. L. Meade, and G. P. Cook (2008)
Brief Funct Genomic Proteomic
   Abstract »    Full Text »    PDF »
Regulation of Human DAP10 Gene Expression in NK and T Cells by Ap-1 Transcription Factors.
A. I. Marusina, S. J. Burgess, I. Pathmanathan, F. Borrego, and J. E. Coligan (2008)
J. Immunol. 180, 409-417
   Abstract »    Full Text »    PDF »
Phosphatidylinositol 3-Kinase Activation Is Required To Form the NKG2D Immunological Synapse.
E. Giurisato, M. Cella, T. Takai, T. Kurosaki, Y. Feng, G. D. Longmore, M. Colonna, and A. S. Shaw (2007)
Mol. Cell. Biol. 27, 8583-8599
   Abstract »    Full Text »    PDF »
Molecular Regulation of MHC Class I Chain-Related Protein A Expression after HDAC-Inhibitor Treatment of Jurkat T Cells.
L. Andresen, H. Jensen, M. T. Pedersen, K. A. Hansen, and S. Skov (2007)
J. Immunol. 179, 8235-8242
   Abstract »    Full Text »    PDF »
NKG2D-Mediated Antitumor Activity by Tumor-Infiltrating Lymphocytes and Antigen-Specific T-Cell Clones Isolated from Melanoma Patients.
C. Maccalli, D. Nonaka, A. Piris, D. Pende, L. Rivoltini, C. Castelli, and G. Parmiani (2007)
Clin. Cancer Res. 13, 7459-7468
   Abstract »    Full Text »    PDF »
Differing Phenotypes between Intraepithelial and Stromal Lymphocytes in Early-Stage Tongue Cancer.
F. Katou, H. Ohtani, Y. Watanabe, T. Nakayama, O. Yoshie, and K. Hashimoto (2007)
Cancer Res. 67, 11195-11201
   Abstract »    Full Text »    PDF »
The Role of NKG2D Signaling in Inhibition of Cytotoxic T-Lymphocyte Lysis by the Murine Cytomegalovirus Immunoevasin m152/gp40.
A. K. Pinto, A. M. Jamieson, D. H. Raulet, and A. B. Hill (2007)
J. Virol. 81, 12564-12571
   Abstract »    Full Text »    PDF »
A phenotypic and functional characterization of NK cells in adenoids.
S. Mizrahi, E. Yefenof, M. Gross, P. Attal, A. Ben Yaakov, D. Goldman-Wohl, B. Maly, N. Stern, G. Katz, R. Gazit, et al. (2007)
J. Leukoc. Biol. 82, 1095-1105
   Abstract »    Full Text »    PDF »
The Rheumatoid Arthritis Shared Epitope Triggers Innate Immune Signaling via Cell Surface Calreticulin.
S. Ling, X. Pi, and J. Holoshitz (2007)
J. Immunol. 179, 6359-6367
   Abstract »    Full Text »    PDF »
Mutations Designed to Destabilize the Receptor-Bound Conformation Increase MICA-NKG2D Association Rate and Affinity.
C. S. E. Lengyel, L. J. Willis, P. Mann, D. Baker, T. Kortemme, R. K. Strong, and B. J. McFarland (2007)
J. Biol. Chem. 282, 30658-30666
   Abstract »    Full Text »    PDF »
The Heat Shock Protein HSP70 Promotes Mouse NK Cell Activity against Tumors That Express Inducible NKG2D Ligands.
L. Elsner, V. Muppala, M. Gehrmann, J. Lozano, D. Malzahn, H. Bickeboller, E. Brunner, M. Zientkowska, T. Herrmann, L. Walter, et al. (2007)
J. Immunol. 179, 5523-5533
   Abstract »    Full Text »    PDF »
EAE Tolerance Induction with Hsp70-Peptide Complexes Depends on H60 and NKG2D Activity.
G. Galazka, A. Jurewicz, W. Orlowski, M. Stasiolek, C. F. Brosnan, C. S. Raine, and K. Selmaj (2007)
J. Immunol. 179, 4503-4512
   Abstract »    Full Text »    PDF »
4-1BB Is Superior to CD28 Costimulation for Generating CD8+ Cytotoxic Lymphocytes for Adoptive Immunotherapy.
H. Zhang, K. M. Snyder, M. M. Suhoski, M. V. Maus, V. Kapoor, C. H. June, and C. L. Mackall (2007)
J. Immunol. 179, 4910-4918
   Abstract »    Full Text »    PDF »
Induction of NKG2D ligands on human dendritic cells by TLR ligand stimulation and RNA virus infection.
T. Ebihara, H. Masuda, T. Akazawa, M. Shingai, H. Kikuta, T. Ariga, M. Matsumoto, and T. Seya (2007)
Int. Immunol. 19, 1145-1155
   Abstract »    Full Text »    PDF »
The immunogenicity of Bcr-Abl expressing dendritic cells is dependent on the Bcr-Abl kinase activity and dominated by Bcr-Abl regulated antigens.
F. Scheich, J. Duyster, C. Peschel, and H. Bernhard (2007)
Blood 110, 2556-2560
   Abstract »    Full Text »    PDF »
Cryoelectron Tomographic Analysis of an HIV-neutralizing Protein and Its Complex with Native Viral gp120.
A. Bennett, J. Liu, D. Van Ryk, D. Bliss, J. Arthos, R. M. Henderson, and S. Subramaniam (2007)
J. Biol. Chem. 282, 27754-27759
   Abstract »    Full Text »    PDF »
Engagement of TLR3, TLR7, and NKG2D Regulate IFN-{gamma} Secretion but Not NKG2D-Mediated Cytotoxicity by Human NK Cells Stimulated with Suboptimal Doses of IL-12.
M. V. Girart, M. B. Fuertes, C. I. Domaica, L. E. Rossi, and N. W. Zwirner (2007)
J. Immunol. 179, 3472-3479
   Abstract »    Full Text »    PDF »
Bcl10 Plays a Divergent Role in NK Cell-Mediated Cytotoxicity and Cytokine Generation.
S. Malarkannan, J. Regunathan, H. Chu, S. Kutlesa, Y. Chen, H. Zeng, R. Wen, and D. Wang (2007)
J. Immunol. 179, 3752-3762
   Abstract »    Full Text »    PDF »
DAP10 Deficiency Breaks the Immune Tolerance against Transplantable Syngeneic Melanoma.
N. Hyka-Nouspikel, L. Lucian, E. Murphy, T. McClanahan, and J. H. Phillips (2007)
J. Immunol. 179, 3763-3771
   Abstract »    Full Text »    PDF »
Transforming Growth Factor-{beta} and the Immune Response: Implications for Anticancer Therapy.
S. H. Wrzesinski, Y. Y. Wan, and R. A. Flavell (2007)
Clin. Cancer Res. 13, 5262-5270
   Abstract »    Full Text »    PDF »
Autoimmune Diabetes Mellitus with Adult Onset and Type 1 Diabetes Mellitus in Children Have Different Genetic Predispositions.
M. CERNA, K. KOLOSTOVA, P. NOVOTA, M. ROMZOVA, P. CEJKOVA, D. PINTEROVA, S. PRUHOVA, L. TRESLOVA, and M. ANDEL (2007)
Ann. N.Y. Acad. Sci. 1110, 140-150
   Abstract »    Full Text »    PDF »
Natural Killer Cells in Perinatally HIV-1-Infected Children Exhibit Less Degranulation Compared to HIV-1-Exposed Uninfected Children and Their Expression of KIR2DL3, NKG2C, and NKp46 Correlates with Disease Severity.
W. M. Ballan, B.-A. N. Vu, B. R. Long, C. P. Loo, J. Michaelsson, J. D. Barbour, L. L. Lanier, A. A. Wiznia, J. Abadi, G. J. Fennelly, et al. (2007)
J. Immunol. 179, 3362-3370
   Abstract »    Full Text »    PDF »
The unexpected effect of cyclosporin A on CD56+CD16 and CD56+CD16+ natural killer cell subpopulations.
H. Wang, B. Grzywacz, D. Sukovich, V. McCullar, Q. Cao, A. B. Lee, B. R. Blazar, D. N. Cornfield, J. S. Miller, and M. R. Verneris (2007)
Blood 110, 1530-1539
   Abstract »    Full Text »    PDF »
HIV modulates the expression of ligands important in triggering natural killer cell cytotoxic responses on infected primary T-cell blasts.
J. Ward, M. Bonaparte, J. Sacks, J. Guterman, M. Fogli, D. Mavilio, and E. Barker (2007)
Blood 110, 1207-1214
   Abstract »    Full Text »    PDF »
Host Immune System Gene Targeting by a Viral miRNA.
N. Stern-Ginossar, N. Elefant, A. Zimmermann, D. G. Wolf, N. Saleh, M. Biton, E. Horwitz, Z. Prokocimer, M. Prichard, G. Hahn, et al. (2007)
Science 317, 376-381
   Abstract »    Full Text »    PDF »
Host Perforin Reduces Tumor Number but Does Not Increase Survival in Oncogene-Driven Mammary Adenocarcinoma.
S. E.A. Street, N. Zerafa, M. Iezzi, J. A. Westwood, J. Stagg, P. Musiani, and M. J. Smyth (2007)
Cancer Res. 67, 5454-5460
   Abstract »    Full Text »    PDF »
Genomics and Diversity of the Common Marmoset Monkey NK Complex.
A. Averdam, H. Kuhl, M. Sontag, T. Becker, A. L. Hughes, R. Reinhardt, and L. Walter (2007)
J. Immunol. 178, 7151-7161
   Abstract »    Full Text »    PDF »
Functional characterization of natural killer cells in type I leukocyte adhesion deficiency.
R. Castriconi, A. Dondero, C. Cantoni, M. Della Chiesa, C. Prato, M. Nanni, M. Fiorini, L. Notarangelo, S. Parolini, L. Moretta, et al. (2007)
Blood 109, 4873-4881
   Abstract »    Full Text »    PDF »
Reduced natural killer (NK) function associated with high-risk myelodysplastic syndrome (MDS) and reduced expression of activating NK receptors.
P. K. Epling-Burnette, F. Bai, J. S. Painter, D. E. Rollison, H. R. Salih, M. Krusch, J. Zou, E. Ku, B. Zhong, D. Boulware, et al. (2007)
Blood 109, 4816-4824
   Abstract »    Full Text »    PDF »
Inhibitory Receptor Signals Suppress Ligation-Induced Recruitment of NKG2D to GM1-Rich Membrane Domains at the Human NK Cell Immune Synapse.
J. Endt, F. E. McCann, C. R. Almeida, D. Urlaub, R. Leung, D. Pende, D. M. Davis, and C. Watzl (2007)
J. Immunol. 178, 5606-5611
   Abstract »    Full Text »    PDF »
NKG2D recognition mediates Toll-like receptor 3 signaling-induced breakdown of epithelial homeostasis in the small intestines of mice.
R. Zhou, H. Wei, R. Sun, J. Zhang, and Z. Tian (2007)
PNAS 104, 7512-7515
   Abstract »    Full Text »    PDF »
Molecular analysis of the methylprednisolone-mediated inhibition of NK-cell function: evidence for different susceptibility of IL-2- versus IL-15-activated NK cells.
L. Chiossone, C. Vitale, F. Cottalasso, S. Moretti, B. Azzarone, L. Moretta, and M. C. Mingari (2007)
Blood 109, 3767-3775
   Abstract »    Full Text »    PDF »
Adenovirus vector delivery stimulates natural killer cell recognition.
P. Tomasec, E. C. Y. Wang, V. Groh, T. Spies, B. P. McSharry, R. J. Aicheler, R. J. Stanton, and G. W. G. Wilkinson (2007)
J. Gen. Virol. 88, 1103-1108
   Abstract »    Full Text »    PDF »
The Human Cytomegalovirus MHC Class I Homolog UL18 Inhibits LIR-1+ but Activates LIR-1- NK Cells.
V. Prod'homme, C. Griffin, R. J. Aicheler, E. C. Y. Wang, B. P. McSharry, C. R. Rickards, R. J. Stanton, L. K. Borysiewicz, M. Lopez-Botet, G. W. G. Wilkinson, et al. (2007)
J. Immunol. 178, 4473-4481
   Abstract »    Full Text »    PDF »
The Activating NKG2D Ligand MHC Class I-Related Chain A Transfers from Target Cells to NK Cells in a Manner That Allows Functional Consequences.
F. E. McCann, P. Eissmann, B. Onfelt, R. Leung, and D. M. Davis (2007)
J. Immunol. 178, 3418-3426
   Abstract »    Full Text »    PDF »
Attenuation of the Glucocorticoid Response during Ad5IL-12 Adenovirus Vector Treatment Enhances Natural Killer Cell-Mediated Killing of MHC Class I-Negative LNCaP Prostate Tumors.
C. Raja Gabaglia, Y. Diaz de Durana, F. L. Graham, J. Gauldie, E. E. Sercarz, and T. A. Braciak (2007)
Cancer Res. 67, 2290-2297
   Abstract »    Full Text »    PDF »
NKp46 and NKG2D Recognition of Infected Dendritic Cells Is Necessary for NK Cell Activation in the Human Response to Influenza Infection.
M. Draghi, A. Pashine, B. Sanjanwala, K. Gendzekhadze, C. Cantoni, D. Cosman, A. Moretta, N. M. Valiante, and P. Parham (2007)
J. Immunol. 178, 2688-2698
   Abstract »    Full Text »    PDF »
DNAX Accessory Molecule-1 Mediated Recognition of Freshly Isolated Ovarian Carcinoma by Resting Natural Killer Cells.
M. Carlsten, N. K. Bjorkstrom, H. Norell, Y. Bryceson, T. van Hall, B. C. Baumann, M. Hanson, K. Schedvins, R. Kiessling, H.-G. Ljunggren, et al. (2007)
Cancer Res. 67, 1317-1325
   Abstract »    Full Text »    PDF »
The Switch from Latent to Productive Infection in Epstein-Barr Virus-Infected B Cells Is Associated with Sensitization to NK Cell Killing.
I. Y. Pappworth, E. C. Wang, and M. Rowe (2007)
J. Virol. 81, 474-482
   Abstract »    Full Text »    PDF »
Decreased NKG2D Expression on CD8+ T Cell Is Involved in Immune Evasion in Patients with Gastric Cancer.
T. Osaki, H. Saito, T. Yoshikawa, S. Matsumoto, S. Tatebe, S. Tsujitani, and M. Ikeguchi (2007)
Clin. Cancer Res. 13, 382-387
   Abstract »    Full Text »    PDF »
Increased surveillance of cells in mitosis by human NK cells suggests a novel strategy for limiting tumor growth and viral replication.
E. N. M. Nolte-'t Hoen, C. R. Almeida, N. R. Cohen, S. Nedvetzki, H. Yarwood, and D. M. Davis (2007)
Blood 109, 670-673
   Abstract »    Full Text »    PDF »
Human immunodeficiency virus 1 Nef protein downmodulates the ligands of the activating receptor NKG2D and inhibits natural killer cell-mediated cytotoxicity.
C. Cerboni, F. Neri, N. Casartelli, A. Zingoni, D. Cosman, P. Rossi, A. Santoni, and M. Doria (2007)
J. Gen. Virol. 88, 242-250
   Abstract »    Full Text »    PDF »
Human Effector CD8+ T Lymphocytes Express TLR3 as a Functional Coreceptor.
J. Tabiasco, E. Devevre, N. Rufer, B. Salaun, J.-C. Cerottini, D. Speiser, and P. Romero (2006)
J. Immunol. 177, 8708-8713
   Abstract »    Full Text »    PDF »
The tryptophan catabolite L-kynurenine inhibits the surface expression of NKp46- and NKG2D-activating receptors and regulates NK-cell function.
M. D. Chiesa, S. Carlomagno, G. Frumento, M. Balsamo, C. Cantoni, R. Conte, L. Moretta, A. Moretta, and M. Vitale (2006)
Blood 108, 4118-4125
   Abstract »    Full Text »    PDF »
Gene and protein characteristics reflect functional diversity of CD56dim and CD56bright NK cells.
K. Wendt, E. Wilk, S. Buyny, J. Buer, R. E. Schmidt, and R. Jacobs (2006)
J. Leukoc. Biol. 80, 1529-1541
   Abstract »    Full Text »    PDF »
Differential and Nonredundant Roles of Phospholipase C{gamma}2 and Phospholipase C{gamma}1 in the Terminal Maturation of NK Cells.
J. Regunathan, Y. Chen, S. Kutlesa, X. Dai, L. Bai, R. Wen, D. Wang, and S. Malarkannan (2006)
J. Immunol. 177, 5365-5376
   Abstract »    Full Text »    PDF »
Transcriptional Regulation of ULBP1, a Human Ligand of the NKG2D Receptor.
A. Lopez-Soto, A. Quinones-Lombrana, R. Lopez-Arbesu, C. Lopez-Larrea, and S. Gonzalez (2006)
J. Biol. Chem. 281, 30419-30430
   Abstract »    Full Text »    PDF »
Phase II Study of Belagenpumatucel-L, a Transforming Growth Factor Beta-2 Antisense Gene-Modified Allogeneic Tumor Cell Vaccine in Non-Small-Cell Lung Cancer.
J. Nemunaitis, R. O. Dillman, P. O. Schwarzenberger, N. Senzer, C. Cunningham, J. Cutler, A. Tong, P. Kumar, B. Pappen, C. Hamilton, et al. (2006)
J. Clin. Oncol. 24, 4721-4730
   Abstract »    Full Text »    PDF »
Genes Influencing Innate and Acquired Immunity in Type 1 Diabetes and Latent Autoimmune Diabetes in Adults.
C. B SANJEEVI (2006)
Ann. N.Y. Acad. Sci. 1079, 67-80
   Abstract »    Full Text »    PDF »
CD94/NKG2A Inhibits NK Cell Activation by Disrupting the Actin Network at the Immunological Synapse.
M. Masilamani, C. Nguyen, J. Kabat, F. Borrego, and J. E. Coligan (2006)
J. Immunol. 177, 3590-3596
   Abstract »    Full Text »    PDF »
Human Cytomegalovirus-Encoded UL16 Discriminates MIC Molecules by Their {alpha}2 Domains..
J. Spreu, T. Stehle, and A. Steinle (2006)
J. Immunol. 177, 3143-3149
   Abstract »    Full Text »    PDF »
TGF-{beta} and metalloproteinases differentially suppress NKG2D ligand surface expression on malignant glioma cells.
G. Eisele, J. Wischhusen, M. Mittelbronn, R. Meyermann, I. Waldhauer, A. Steinle, M. Weller, and M. A. Friese (2006)
Brain 129, 2416-2425
   Abstract »    Full Text »    PDF »
Porcine UL16-Binding Protein 1 Expressed on the Surface of Endothelial Cells Triggers Human NK Cytotoxicity through NKG2D.
B. G. Lilienfeld, C. Garcia-Borges, M. D. Crew, and J. D. Seebach (2006)
J. Immunol. 177, 2146-2152
   Abstract »    Full Text »    PDF »
ULBPs, human ligands of the NKG2D receptor, stimulate tumor immunity with enhancement by IL-15.
C. L. Sutherland, B. Rabinovich, N. J. Chalupny, P. Brawand, R. Miller, and D. Cosman (2006)
Blood 108, 1313-1319
   Abstract »    Full Text »    PDF »
Antitumor immune response induced by i.t. injection of vector-activated dendritic cells and chemotherapy suppresses metastatic breast cancer..
H. Akbulut, Y. Tang, K. G. Akbulut, J. Maynard, L. Zhang, and A. Deisseroth (2006)
Mol. Cancer Ther. 5, 1975-1985
   Abstract »    Full Text »    PDF »
NKG2D ligands are expressed on stressed human airway epithelial cells.
M. T. Borchers, N. L. Harris, S. C. Wesselkamper, M. Vitucci, and D. Cosman (2006)
Am J Physiol Lung Cell Mol Physiol 291, L222-L231
   Abstract »    Full Text »    PDF »
Distinct indirect pathways govern human NK-cell activation by TLR-7 and TLR-8 agonists.
K. S. Gorski, E. L. Waller, J. Bjornton-Severson, J. A. Hanten, C. L. Riter, W. C. Kieper, K. B. Gorden, J. S. Miller, J. P. Vasilakos, M. A. Tomai, et al. (2006)
Int. Immunol. 18, 1115-1126
   Abstract »    Full Text »    PDF »
Therapy-induced antibodies to MHC class I chain-related protein A antagonize immune suppression and stimulate antitumor cytotoxicity.
M. Jinushi, F. S. Hodi, and G. Dranoff (2006)
PNAS 103, 9190-9195
   Abstract »    Full Text »    PDF »
Regulation of Ly49D/DAP12 Signal Transduction by Src-Family Kinases and CD45..
L. H. Mason, J. Willette-Brown, L. S. Taylor, and D. W. McVicar (2006)
J. Immunol. 176, 6615-6623
   Abstract »    Full Text »    PDF »
Reprogramming of CTLs into natural killer-like cells in celiac disease.
B. Meresse, S. A. Curran, C. Ciszewski, G. Orbelyan, M. Setty, G. Bhagat, L. Lee, M. Tretiakova, C. Semrad, E. Kistner, et al. (2006)
J. Exp. Med. 203, 1343-1355
   Abstract »    Full Text »    PDF »
The NKG2D-Activating Receptor Mediates Pulmonary Clearance of Pseudomonas aeruginosa..
M. T. Borchers, N. L. Harris, S. C. Wesselkamper, S. Zhang, Y. Chen, L. Young, and G. W. Lau (2006)
Infect. Immun. 74, 2578-2586
   Abstract »    Full Text »    PDF »
The DNA damage response arouses the immune system..
S. Gasser and D. H. Raulet (2006)
Cancer Res. 66, 3959-3962
   Abstract »    Full Text »    PDF »
BCR/ABL oncogene directly controls MHC class I chain-related molecule A expression in chronic myelogenous leukemia..
N. Boissel, D. Rea, V. Tieng, N. Dulphy, M. Brun, J.-M. Cayuela, P. Rousselot, R. Tamouza, P. Le Bouteiller, F.-X. Mahon, et al. (2006)
J. Immunol. 176, 5108-5116
   Abstract »    Full Text »    PDF »
Homing and Function of Human Skin {gamma}{delta} T Cells and NK Cells: Relevance for Tumor Surveillance.
L. M. Ebert, S. Meuter, and B. Moser (2006)
J. Immunol. 176, 4331-4336
   Abstract »    Full Text »    PDF »
Synergistic antitumor effects of immune cell-viral biotherapy..
S. H. Thorne, R. S. Negrin, and C. H. Contag (2006)
Science 311, 1780-1784
   Abstract »    Full Text »    PDF »
Placenta-Derived Soluble MHC Class I Chain-Related Molecules Down-Regulate NKG2D Receptor on Peripheral Blood Mononuclear Cells during Human Pregnancy: A Possible Novel Immune Escape Mechanism for Fetal Survival.
L. Mincheva-Nilsson, O. Nagaeva, T. Chen, U. Stendahl, J. Antsiferova, I. Mogren, J. Hernestal, and V. Baranov (2006)
J. Immunol. 176, 3585-3592
   Abstract »    Full Text »    PDF »
Enhanced killing of primary ovarian cancer by retargeting autologous cytokine-induced killer cells with bispecific antibodies: a preclinical study..
J. K. Chan, C. A. Hamilton, M. K. Cheung, M. Karimi, J. Baker, J. M. Gall, S. Schulz, S. H. Thorne, N. N. Teng, C. H. Contag, et al. (2006)
Clin. Cancer Res. 12, 1859-1867
   Abstract »    Full Text »    PDF »