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Science 30 July 1999: Vol. 285. no. 5428, pp. 727 - 729 DOI: 10.1126/science.285.5428.727
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Reports
Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA
Stefan Bauer,
1*
Veronika Groh,
1*
Jun Wu,
2
Alexander Steinle,
1
Joseph H. Phillips,
2
Lewis L. Lanier,
2
Thomas Spies
1
Stress-inducible MICA, a distant homolog of major
histocompatibility complex (MHC) class I, functions as an antigen for
 T cells and is frequently expressed in epithelial tumors. A
receptor for MICA was detected on most  T cells, CD8+
 T cells, and natural killer (NK) cells and was identified as
NKG2D. Effector cells from all these subsets could be stimulated by
ligation of NKG2D. Engagement of NKG2D activated cytolytic responses of
 T cells and NK cells against transfectants and epithelial tumor
cells expressing MICA. These results define an activating
immunoreceptor-MHC ligand interaction that may promote antitumor NK and
T cell responses.
1 Fred Hutchinson Cancer Research Center, Clinical
Research Division, 1100 Fairview Avenue North, Seattle, WA 98109, USA.
2 DNAX Research Institute of Molecular and Cellular Biology,
Palo Alto, CA 94304, USA.
*
These authors contributed equally to this work and are listed in
alphabetical order.
Present address: Technical University of Munich, Institute of
Microbiology, Trogerstrasse 32, D-81675 Munich, Germany.
To whom correspondence should be addressed. E-mail:
tspies{at}fred.fhcrc.org
Read the Full Text
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- 4-1BB Is Superior to CD28 Costimulation for Generating CD8+ Cytotoxic Lymphocytes for Adoptive Immunotherapy.
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J. Immunol.
179, 4910-4918
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- Induction of NKG2D ligands on human dendritic cells by TLR ligand stimulation and RNA virus infection.
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Int. Immunol.
19, 1145-1155
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- The immunogenicity of Bcr-Abl expressing dendritic cells is dependent on the Bcr-Abl kinase activity and dominated by Bcr-Abl regulated antigens.
- F. Scheich, J. Duyster, C. Peschel, and H. Bernhard (2007)
Blood
110, 2556-2560
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- Cryoelectron Tomographic Analysis of an HIV-neutralizing Protein and Its Complex with Native Viral gp120.
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282, 27754-27759
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- Engagement of TLR3, TLR7, and NKG2D Regulate IFN-{gamma} Secretion but Not NKG2D-Mediated Cytotoxicity by Human NK Cells Stimulated with Suboptimal Doses of IL-12.
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J. Immunol.
179, 3472-3479
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- Bcl10 Plays a Divergent Role in NK Cell-Mediated Cytotoxicity and Cytokine Generation.
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179, 3752-3762
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- DAP10 Deficiency Breaks the Immune Tolerance against Transplantable Syngeneic Melanoma.
- N. Hyka-Nouspikel, L. Lucian, E. Murphy, T. McClanahan, and J. H. Phillips (2007)
J. Immunol.
179, 3763-3771
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- Transforming Growth Factor-{beta} and the Immune Response: Implications for Anticancer Therapy.
- S. H. Wrzesinski, Y. Y. Wan, and R. A. Flavell (2007)
Clin. Cancer Res.
13, 5262-5270
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- Natural Killer Cells in Perinatally HIV-1-Infected Children Exhibit Less Degranulation Compared to HIV-1-Exposed Uninfected Children and Their Expression of KIR2DL3, NKG2C, and NKp46 Correlates with Disease Severity.
- W. M. Ballan, B.-A. N. Vu, B. R. Long, C. P. Loo, J. Michaelsson, J. D. Barbour, L. L. Lanier, A. A. Wiznia, J. Abadi, G. J. Fennelly, et al. (2007)
J. Immunol.
179, 3362-3370
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- The unexpected effect of cyclosporin A on CD56+CD16 and CD56+CD16+ natural killer cell subpopulations.
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Blood
110, 1530-1539
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- HIV modulates the expression of ligands important in triggering natural killer cell cytotoxic responses on infected primary T-cell blasts.
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Blood
110, 1207-1214
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