Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 9 July 1999:
Vol. 285. no. 5425, pp. 260 - 263
DOI: 10.1126/science.285.5425.260
Prev | Table of Contents | Next

Reports

BLyS: Member of the Tumor Necrosis Factor Family and B Lymphocyte Stimulator

Paul A. Moore, Ornella Belvedere, Amy Orr, Krystyna Pieri, David W. LaFleur, Ping Feng, Daniel Soppet, Meghan Charters, Reiner Gentz, David Parmelee, Yuling Li, Olga Galperina, Judith Giri, Viktor Roschke, Bernardetta Nardelli, Jeffrey Carrell, Svetlana Sosnovtseva, Wilbert Greenfield, Steven M. Ruben, Henrik S. Olsen, James Fikes, David M. Hilbert *

The tumor necrosis factor (TNF) superfamily of cytokines includes both soluble and membrane-bound proteins that regulate immune responses. A member of the human TNF family, BLyS (B lymphocyte stimulator), was identified that induced B cell proliferation and immunoglobulin secretion. BLyS expression on human monocytes could be up-regulated by interferon-gamma . Soluble BLyS functioned as a potent B cell growth factor in costimulation assays. Administration of soluble recombinant BLyS to mice disrupted splenic B and T cell zones and resulted in elevated serum immunoglobulin concentrations. The B cell tropism of BLyS is consistent with its receptor expression on B-lineage cells. The biological profile of BLyS suggests it is involved in monocyte-driven B cell activation.

Human Genome Sciences, 9410 Key West Avenue, Rockville, MD 20850, USA.
*   To whom correspondence should be addressed. E-mail: david_hilbert{at}hgsi.com

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
ITP has elevated BAFF expression.
J. W. Semple (2009)
Blood 114, 5248-5249
   Full Text »    PDF »
The effects of BAFF and BAFF-R-Fc fusion protein in immune thrombocytopenia.
X.-j. Zhu, Y. Shi, J. Peng, C.-s. Guo, N.-n. Shan, P. Qin, X.-b. Ji, and M. Hou (2009)
Blood 114, 5362-5367
   Abstract »    Full Text »    PDF »
Adipocytes as Immune Cells: Differential Expression of TWEAK, BAFF, and APRIL and Their Receptors (Fn14, BAFF-R, TACI, and BCMA) at Different Stages of Normal and Pathological Adipose Tissue Development.
V.-I. Alexaki, G. Notas, V. Pelekanou, M. Kampa, M. Valkanou, P. Theodoropoulos, E. N. Stathopoulos, A. Tsapis, and E. Castanas (2009)
J. Immunol. 183, 5948-5956
   Abstract »    Full Text »    PDF »
Functional implication of BAFF synthesis and release in gangliosides-stimulated microglia.
K. S. Kim, J.-Y. Park, I. Jou, and S. M. Park (2009)
J. Leukoc. Biol. 86, 349-359
   Abstract »    Full Text »    PDF »
Expression of B-Cell Activating Factor Enhances Protective Immunity of a Vaccine against Pseudomonas aeruginosa.
C. Tertilt, J. Joh, A. Krause, P. Chou, K. Schneeweiss, R. G. Crystal, and S. Worgall (2009)
Infect. Immun. 77, 3044-3055
   Abstract »    Full Text »    PDF »
Notch Ligands Expressed by Follicular Dendritic Cells Protect Germinal Center B Cells from Apoptosis.
S.-O. Yoon, X. Zhang, P. Berner, B. Blom, and Y. S. Choi (2009)
J. Immunol. 183, 352-358
   Abstract »    Full Text »    PDF »
Quantitative assessment of antibodies to ribonucleoproteins in primary Sjogren syndrome: correlation with B-cell biomarkers and disease activity.
S Candon, J E Gottenberg, D Bengoufa, L Chatenoud, and X Mariette (2009)
Ann Rheum Dis 68, 1208-1212
   Abstract »    Full Text »    PDF »
A proliferation-inducing ligand mediates follicular lymphoma B-cell proliferation and cyclin D1 expression through phosphatidylinositol 3-kinase-regulated mammalian target of rapamycin activation.
M. Gupta, S. R. Dillon, S. C. Ziesmer, A. L. Feldman, T. E. Witzig, S. M. Ansell, J. R. Cerhan, and A. J. Novak (2009)
Blood 113, 5206-5216
   Abstract »    Full Text »    PDF »
Genetic Variation in B-Cell-Activating Factor Is Associated with an Increased Risk of Developing B-Cell Non-Hodgkin Lymphoma.
A. J. Novak, S. L. Slager, Z. S. Fredericksen, A. H. Wang, M. M. Manske, S. Ziesmer, M. Liebow, W. R. Macon, S. R. Dillon, T. E. Witzig, et al. (2009)
Cancer Res. 69, 4217-4224
   Abstract »    Full Text »    PDF »
An exploratory dose-escalating study investigating the safety, tolerability, pharmacokinetics and pharmacodynamics of intravenous atacicept in patients with systemic lupus erythematosus.
C Pena-Rossi, E Nasonov, M Stanislav, V Yakusevich, O Ershova, N Lomareva, H Saunders, J Hill, and I Nestorov (2009)
Lupus 18, 547-555
   Abstract »    PDF »
Fc{gamma}RIIB signals inhibit BLyS signaling and BCR-mediated BLyS receptor up-regulation.
J. E. Crowley, J. E. Stadanlick, J. C. Cambier, and M. P. Cancro (2009)
Blood 113, 1464-1473
   Abstract »    Full Text »    PDF »
Preclinical Support for Combination Therapy in the Treatment of Autoimmunity with Atacicept.
R. Ponce (2009)
Toxicol Pathol 37, 89-99
   Abstract »    Full Text »    PDF »
A Potential Role for B-Cell Activating Factor in the Pathogenesis of Autoimmune Myasthenia Gravis.
S. Ragheb, R. Lisak, R. Lewis, G. Van Stavern, F. Gonzales, and K. Simon (2008)
Arch Neurol 65, 1358-1362
   Abstract »    Full Text »    PDF »
Overexpression of B cell-activating factor of TNF family (BAFF) is associated with Helicobacter pylori-independent growth of gastric diffuse large B-cell lymphoma with histologic evidence of MALT lymphoma.
S.-H. Kuo, P.-Y. Yeh, L.-T. Chen, M.-S. Wu, C.-W. Lin, K.-H. Yeh, Y.-S. Tzeng, J.-Y. Chen, P.-N. Hsu, J.-T. Lin, et al. (2008)
Blood 112, 2927-2934
   Abstract »    Full Text »    PDF »
Nonclinical Safety, Pharmacokinetics, and Pharmacodynamics of Atacicept.
M. Carbonatto, P. Yu, M. Bertolino, E. Vigna, S. Steidler, L. Fava, C. Daghero, B. Roattino, M. Onidi, M. Ardizzone, et al. (2008)
Toxicol. Sci. 105, 200-210
   Abstract »    Full Text »    PDF »
B lymphocytes: how they develop and function.
T. W. LeBien and T. F. Tedder (2008)
Blood 112, 1570-1580
   Abstract »    Full Text »    PDF »
Excessive Production of IFN-{gamma} in Patients with Systemic Lupus Erythematosus and Its Contribution to Induction of B Lymphocyte Stimulator/B Cell-Activating Factor/TNF Ligand Superfamily-13B.
M. Harigai, M. Kawamoto, M. Hara, T. Kubota, N. Kamatani, and N. Miyasaka (2008)
J. Immunol. 181, 2211-2219
   Abstract »    Full Text »    PDF »
B lymphocyte stimulator expression in patients with rheumatoid arthritis treated with tumour necrosis factor {alpha} antagonists: differential effects between good and poor clinical responders.
D T La, C E Collins, H-T Yang, T-S Migone, and W Stohl (2008)
Ann Rheum Dis 67, 1132-1138
   Abstract »    Full Text »    PDF »
Immune Opsonins Modulate BLyS/BAFF Release in a Receptor-Specific Fashion.
X. Li, K. Su, C. Ji, A. J. Szalai, J. Wu, Y. Zhang, T. Zhou, R. P. Kimberly, and J. C. Edberg (2008)
J. Immunol. 181, 1012-1018
   Abstract »    Full Text »    PDF »
Global T Cell Dysregulation in Non-Autoimmune-Prone Mice Promotes Rapid Development of BAFF-Independent, Systemic Lupus Erythematosus-Like Autoimmunity.
W. Stohl, N. Jacob, W. J. Quinn III, M. P. Cancro, H. Gao, C. Putterman, X. Gao, L. Pricop, and M. N. Koss (2008)
J. Immunol. 181, 833-841
   Abstract »    Full Text »    PDF »
TGF-{beta}1 and IFN-{gamma} stimulate mouse macrophages to express BAFF via different signaling pathways.
H.-A Kim, S.-H. Jeon, G.-Y. Seo, J.-B. Park, and P.-H. Kim (2008)
J. Leukoc. Biol. 83, 1431-1439
   Abstract »    Full Text »    PDF »
B Lymphocyte Stimulator Regulates Adaptive Immune Responses by Directly Promoting Dendritic Cell Maturation.
S. K. Chang, S. A. Mihalcik, and D. F. Jelinek (2008)
J. Immunol. 180, 7394-7403
   Abstract »    Full Text »    PDF »
Treating patients with lupus with B-cell depletion.
D. Isenberg (2008)
Lupus 17, 400-404
   Abstract »    PDF »
Signaling Pathways for B Cell-Activating Factor (BAFF) and a Proliferation-Inducing Ligand (APRIL) in Human Placenta.
D. L. Langat, D. A. Wheaton, J. S. Platt, T. Sifers, and J. S. Hunt (2008)
Am. J. Pathol. 172, 1303-1311
   Abstract »    Full Text »    PDF »
TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts.
C. Bossen, T. G. Cachero, A. Tardivel, K. Ingold, L. Willen, M. Dobles, M. L. Scott, A. Maquelin, E. Belnoue, C.-A. Siegrist, et al. (2008)
Blood 111, 1004-1012
   Abstract »    Full Text »    PDF »
In Vitro and In Vivo Activation Induces BAFF and APRIL Expression in B Cells.
V. T. Chu, P. Enghard, G. Riemekasten, and C. Berek (2007)
J. Immunol. 179, 5947-5957
   Abstract »    Full Text »    PDF »
Antibody targeting of B-cell maturation antigen on malignant plasma cells.
M. C. Ryan, M. Hering, D. Peckham, C. F. McDonagh, L. Brown, K. M. Kim, D. L. Meyer, R. F. Zabinski, I. S. Grewal, and P. J. Carter (2007)
Mol. Cancer Ther. 6, 3009-3018
   Abstract »    Full Text »    PDF »
Neutralizing B-Cell Activating Factor Antibody Improves Survival and Inhibits Osteoclastogenesis in a Severe Combined Immunodeficient Human Multiple Myeloma Model.
P. Neri, S. Kumar, M. T. Fulciniti, S. Vallet, S. Chhetri, S. Mukherjee, Y. Tai, D. Chauhan, P. Tassone, S. Venuta, et al. (2007)
Clin. Cancer Res. 13, 5903-5909
   Abstract »    Full Text »    PDF »
Critical role of monocytes to support normal B cell and diffuse large B cell lymphoma survival and proliferation.
C. G. Mueller, C. Boix, W.-H. Kwan, C. Daussy, E. Fournier, W. H. Fridman, and T. J. Molina (2007)
J. Leukoc. Biol. 82, 567-575
   Abstract »    Full Text »    PDF »
Emerging biological therapies in primary Sjogren's syndrome.
M. Ramos-Casals and P. Brito-Zeron (2007)
Rheumatology 46, 1389-1396
   Abstract »    Full Text »    PDF »
Human endometriosis is associated with plasma cells and overexpression of B lymphocyte stimulator.
A. Hever, R. B. Roth, P. Hevezi, M. E. Marin, J. A. Acosta, H. Acosta, J. Rojas, R. Herrera, D. Grigoriadis, E. White, et al. (2007)
PNAS 104, 12451-12456
   Abstract »    Full Text »    PDF »
Expression of B-cell activating factor of the tumour necrosis factor family (BAFF) in T cells in active systemic lupus erythematosus: the role of BAFF in T cell-dependent B cell pathogenic autoantibody production.
S. Morimoto, S. Nakano, T. Watanabe, Y. Tamayama, A. Mitsuo, Y. Nakiri, J. Suzuki, K. Nozawa, H. Amano, Y. Tokano, et al. (2007)
Rheumatology 46, 1083-1086
   Abstract »    Full Text »    PDF »
TLR Stimulation Modifies BLyS Receptor Expression in Follicular and Marginal Zone B Cells.
L. S. Treml, G. Carlesso, K. L. Hoek, J. E. Stadanlick, T. Kambayashi, R. J. Bram, M. P. Cancro, and W. N. Khan (2007)
J. Immunol. 178, 7531-7539
   Abstract »    Full Text »    PDF »
Decreased B cell activating factor receptor expression on peripheral lymphocytes associated with increased disease activity in primary Sjogren's syndrome and systemic lupus erythematosus.
J. Sellam, C. Miceli-Richard, J.-E. Gottenberg, M. Ittah, F. Lavie, C. Lacabaratz, N. Gestermann, A. Proust, O. Lambotte, and X. Mariette (2007)
Ann Rheum Dis 66, 790-797
   Abstract »    Full Text »    PDF »
Divergent Effects of BAFF on Human Memory B Cell Differentiation into Ig-Secreting Cells.
J. R. Darce, B. K. Arendt, S. K. Chang, and D. F. Jelinek (2007)
J. Immunol. 178, 5612-5622
   Abstract »    Full Text »    PDF »
Role of APRIL (TNFSF13) polymorphisms in the susceptibility to systemic lupus erythematosus in Japanese.
A. Kawasaki, N. Tsuchiya, J. Ohashi, Y. Murakami, T. Fukazawa, M. Kusaoi, S. Morimoto, K. Matsuta, H. Hashimoto, Y. Takasaki, et al. (2007)
Rheumatology 46, 776-782
   Abstract »    Full Text »    PDF »
The role of BLyS/BLyS receptors in anti-chromatin B cell regulation.
B. D. Hondowicz, S. T. Alexander, W. J. Quinn III, A. J. Pagan, M. H. Metzgar, M. P. Cancro, and J. Erikson (2007)
Int. Immunol. 19, 465-475
   Abstract »    Full Text »    PDF »
The growth factor fusion construct containing B-lymphocyte stimulator (BLyS) and the toxin rGel induces apoptosis specifically in BAFF-R-positive CLL cells.
R. Nimmanapalli, M.-A. Lyu, M. Du, M. J. Keating, M. G. Rosenblum, and V. Gandhi (2007)
Blood 109, 2557-2564
   Abstract »    Full Text »    PDF »
Late-onset neutropenia following rituximab results from a hematopoietic lineage competition due to an excessive BAFF-induced B-cell recovery.
B. Terrier, M. Ittah, L. Tourneur, F. Louache, V. Soumelis, F. Lavie, N. Casadevall, S. Candon, A. Hummel, X. Mariette, et al. (2007)
Haematologica 92, e20-e23
   Abstract »    Full Text »    PDF »
Unique and conserved functions of B cell-activating factor of the TNF family (BAFF) in the chicken.
S. Kothlow, I. Morgenroth, Y. Graef, K. Schneider, I. Riehl, P. Staeheli, P. Schneider, and B. Kaspers (2007)
Int. Immunol. 19, 203-215
   Abstract »    Full Text »    PDF »
The rGel/BLyS fusion toxin specifically targets malignant B cells expressing the BLyS receptors BAFF-R, TACI, and BCMA.
M.-A. Lyu, L. H. Cheung, W. N. Hittelman, J. W. Marks, R. C.T. Aguiar, and M. G. Rosenblum (2007)
Mol. Cancer Ther. 6, 460-470
   Abstract »    Full Text »    PDF »
Hepatitis C virus-associated B-cell proliferation--the role of serum B lymphocyte stimulator (BLyS/BAFF).
D. Sene, N. Limal, P. Ghillani-Dalbin, D. Saadoun, J.-C. Piette, and P. Cacoub (2007)
Rheumatology 46, 65-69
   Abstract »    Full Text »    PDF »
Airway Epithelial Cells Produce B Cell-Activating Factor of TNF Family by an IFN-beta-Dependent Mechanism.
A. Kato, A. Q. Truong-Tran, A. L. Scott, K. Matsumoto, and R. P. Schleimer (2006)
J. Immunol. 177, 7164-7172
   Abstract »    Full Text »    PDF »
Enhanced antiviral antibody secretion and attenuated immunopathology during influenza virus infection in nitric oxide synthase-2-deficient mice..
J. P. Jayasekera, C. G. Vinuesa, G. Karupiah, and N. J. C. King (2006)
J. Gen. Virol. 87, 3361-3371
   Abstract »    Full Text »    PDF »
Plasma levels of soluble interleukin 2 receptor, soluble CD30, interleukin 10 and B cell activator of the tumour necrosis factor family during follow-up in vasculitis associated with proteinase 3-antineutrophil cytoplasmic antibodies: associations with disease activity and relapse.
J-S F Sanders, M G Huitma, C G M Kallenberg, and C A Stegeman (2006)
Ann Rheum Dis 65, 1484-1489
   Abstract »    Full Text »    PDF »
Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells.
C. V. Lee, S. G. Hymowitz, H. J. Wallweber, N. C. Gordon, K. L. Billeci, S.-P. Tsai, D. M. Compaan, J. Yin, Q. Gong, R. F. Kelley, et al. (2006)
Blood 108, 3103-3111
   Abstract »    Full Text »    PDF »
The BLyS/BAFF family of ligands and receptors: key targets in the therapy and understanding of autoimmunity.
M P Cancro (2006)
Ann Rheum Dis 65, iii34-iii36
   Abstract »    Full Text »    PDF »
A role for BLyS in the activation of innate immune cells.
S. K. Chang, B. K. Arendt, J. R. Darce, X. Wu, and D. F. Jelinek (2006)
Blood 108, 2687-2694
   Abstract »    Full Text »    PDF »
A BAFF antagonist suppresses experimental autoimmune encephalomyelitis by targeting cell-mediated and humoral immune responses.
N. D. Huntington, R. Tomioka, C. Clavarino, A. M. Chow, D. Linares, P. Mana, J. Rossjohn, T. G. Cachero, F. Qian, S. L. Kalled, et al. (2006)
Int. Immunol. 18, 1473-1485
   Abstract »    Full Text »    PDF »
B-lymphocyte activating factor in systemic lupus erythematosus and rheumatoid arthritis in relation to autoantibody levels, disease measures and time.
A Becker-Merok, C Nikolaisen, and H C Nossent (2006)
Lupus 15, 570-576
   Abstract »    PDF »
Paucity of Clinical Disease despite Serological Autoimmunity and Kidney Pathology in Lupus-Prone New Zealand Mixed 2328 Mice Deficient in BAFF.
C. O. Jacob, L. Pricop, C. Putterman, M. N. Koss, Y. Liu, M. Kollaros, S. A. Bixler, C. M. Ambrose, M. L. Scott, and W. Stohl (2006)
J. Immunol. 177, 2671-2680
   Abstract »    Full Text »    PDF »
Role of B-Cell-Activating Factor in Adhesion and Growth of Human Multiple Myeloma Cells in the Bone Marrow Microenvironment..
Y.-T. Tai, X.-F. Li, I. Breitkreutz, W. Song, P. Neri, L. Catley, K. Podar, T. Hideshima, D. Chauhan, N. Raje, et al. (2006)
Cancer Res. 66, 6675-6682
   Abstract »    Full Text »    PDF »
Aberrant expression of BAFF in T cells of systemic lupus erythematosus, which is recapitulated by a human T cell line, Loucy.
K. Yoshimoto, Y. Takahashi, M. Ogasawara, Y. Setoyama, K. Suzuki, K. Tsuzaka, T. Abe, and T. Takeuchi (2006)
Int. Immunol. 18, 1189-1196
   Abstract »    Full Text »    PDF »
Chronic Administration of Belimumab, a BLyS Antagonist, Decreases Tissue and Peripheral Blood B-Lymphocyte Populations in Cynomolgus Monkeys: Pharmacokinetic, Pharmacodynamic, and Toxicologic Effects.
W. G. Halpern, P. Lappin, T. Zanardi, W. Cai, M. Corcoran, J. Zhong, and K. P. Baker (2006)
Toxicol. Sci. 91, 586-599
   Abstract »    Full Text »    PDF »
Space, Selection, and Surveillance: Setting Boundaries with BLyS..
J. P. Miller, J. E. Stadanlick, and M. P. Cancro (2006)
J. Immunol. 176, 6405-6410
   Abstract »    Full Text »    PDF »
APRIL and BAFF Promote Increased Viability of Replicating Human B2 Cells via Mechanism Involving Cyclooxygenase 2..
P. K. A. Mongini, J. K. Inman, H. Han, R. J. Fattah, S. B. Abramson, and M. Attur (2006)
J. Immunol. 176, 6736-6751
   Abstract »    Full Text »    PDF »
Constitutive NF-{kappa}B and NFAT activation leads to stimulation of the BLyS survival pathway in aggressive B-cell lymphomas.
L. Fu, Y.-C. Lin-Lee, L. V. Pham, A. Tamayo, L. Yoshimura, and R. J. Ford (2006)
Blood 107, 4540-4548
   Abstract »    Full Text »    PDF »
Selective activation of TACI by syndecan-2.
D. Bischof, S. F. Elsawa, G. Mantchev, J. Yoon, G. E. Michels, A. Nilson, S. L. Sutor, J. L. Platt, S. M. Ansell, G. von Bulow, et al. (2006)
Blood 107, 3235-3242
   Abstract »    Full Text »    PDF »
B-lymphocyte stimulator (BLyS) stimulates immunoglobulin production and malignant B-cell growth in Waldenstrom macroglobulinemia.
S. F. Elsawa, A. J. Novak, D. M. Grote, S. C. Ziesmer, T. E. Witzig, R. A. Kyle, S. R. Dillon, B. Harder, J. A. Gross, and S. M. Ansell (2006)
Blood 107, 2882-2888
   Abstract »    Full Text »    PDF »
Elevated Serum B-Lymphocyte Stimulator Levels in Patients With Familial Lymphoproliferative Disorders.
A. J. Novak, D. M. Grote, S. C. Ziesmer, M. P. Kline, M. K. Manske, S. Slager, T. E. Witzig, T. Shanafelt, T. G. Call, N. E. Kay, et al. (2006)
J. Clin. Oncol. 24, 983-987
   Abstract »    Full Text »    PDF »
A Soluble BAFF Antagonist, BR3-Fc, Decreases Peripheral Blood B Cells and Lymphoid Tissue Marginal Zone and Follicular B Cells in Cynomolgus Monkeys.
Y. Vugmeyster, D. Seshasayee, W. Chang, A. Storn, K. Howell, S. Sa, T. Nelson, F. Martin, I. Grewal, E. Gilkerson, et al. (2006)
Am. J. Pathol. 168, 476-489
   Abstract »    Full Text »    PDF »
Innate Immunity and Human B Cell Clonal Expansion: Effects on the Recirculating B2 Subpopulation.
P. K. A. Mongini, J. K. Inman, H. Han, S. L. Kalled, R. J. Fattah, and S. McCormick (2005)
J. Immunol. 175, 6143-6154
   Abstract »    Full Text »    PDF »
A Role for B Cell-Activating Factor of the TNF Family in Chemically Induced Autoimmunity.
Y. Zheng, S. Gallucci, J. P. Gaughan, J. A. Gross, and M. Monestier (2005)
J. Immunol. 175, 6163-6168
   Abstract »    Full Text »    PDF »
B Cell Maturation Antigen, the Receptor for a Proliferation-Inducing Ligand and B Cell-Activating Factor of the TNF Family, Induces Antigen Presentation in B Cells.
M. Yang, H. Hase, D. Legarda-Addison, L. Varughese, B. Seed, and A. T. Ting (2005)
J. Immunol. 175, 2814-2824
   Abstract »    Full Text »    PDF »
Expression and function of TNF family member B cell-activating factor in the development of autoimmune arthritis.
M. Zhang, K.-H. Ko, Q. L. K. Lam, C. K. C. Lo, G. Srivastava, B. Zheng, Y.-L. Lau, and L. Lu (2005)
Int. Immunol. 17, 1081-1092
   Abstract »    Full Text »    PDF »
Nurselike cells express BAFF and APRIL, which can promote survival of chronic lymphocytic leukemia cells via a paracrine pathway distinct from that of SDF-1{alpha}.
M. Nishio, T. Endo, N. Tsukada, J. Ohata, S. Kitada, J. C. Reed, N. J. Zvaifler, and T. J. Kipps (2005)
Blood 106, 1012-1020
   Abstract »    Full Text »    PDF »
The level of TACI gene expression in myeloma cells is associated with a signature of microenvironment dependence versus a plasmablastic signature.
J. Moreaux, F. W. Cremer, T. Reme, M. Raab, K. Mahtouk, P. Kaukel, V. Pantesco, J. De Vos, E. Jourdan, A. Jauch, et al. (2005)
Blood 106, 1021-1030
   Abstract »    Full Text »    PDF »
Neisseria gonorrhoeae Kills Carcinoembryonic Antigen-Related Cellular Adhesion Molecule 1 (CD66a)-Expressing Human B Cells and Inhibits Antibody Production.
M. Pantelic, Y.-J. Kim, S. Bolland, I. Chen, J. Shively, and T. Chen (2005)
Infect. Immun. 73, 4171-4179
   Abstract »    Full Text »    PDF »
{Delta}BAFF, a Splice Isoform of BAFF, Opposes Full-Length BAFF Activity In Vivo in Transgenic Mouse Models.
A. L. Gavin, B. Duong, P. Skog, D. Ait-Azzouzene, D. R. Greaves, M. L. Scott, and D. Nemazee (2005)
J. Immunol. 175, 319-328
   Abstract »    Full Text »    PDF »
Correlation of serum B lymphocyte stimulator and {beta}2 microglobulin with autoantibody secretion and systemic involvement in primary Sjogren's syndrome.
J-E Gottenberg, M Busson, J Cohen-Solal, F Lavie, K Abbed, R P Kimberly, J Sibilia, and X Mariette (2005)
Ann Rheum Dis 64, 1050-1055
   Abstract »    Full Text »    PDF »
BAFF supports human B cell differentiation in the lymphoid follicles through distinct receptors.
X. Zhang, C.-S. Park, S.-O. Yoon, L. Li, Y.-M. Hsu, C. Ambrose, and Y. S. Choi (2005)
Int. Immunol. 17, 779-788
   Abstract »    Full Text »    PDF »
B Lymphocyte Stimulator Activates p38 Mitogen-Activated Protein Kinase in Human Ig Class Switch Recombination.
T. Yamada, K. Zhang, A. Yamada, D. Zhu, and A. Saxon (2005)
Am. J. Respir. Cell Mol. Biol. 32, 388-394
   Abstract »    Full Text »    PDF »
Raised levels of anti-glucose-6-phosphate isomerase IgG in serum and synovial fluid from patients with inflammatory arthritis.
M Schaller, W Stohl, S M Tan, V M Benoit, D M Hilbert, and H J Ditzel (2005)
Ann Rheum Dis 64, 743-749
   Abstract »    Full Text »    PDF »
BLyS antagonists and peptide tolerance induction.
J T Merrill (2005)
Lupus 14, 204-209
   Abstract »    PDF »
Enhanced Apoptotic Cell Clearance Capacity and B Cell Survival Factor Production by IL-10-Activated Macrophages: Implications for Burkitt's Lymphoma.
C. A. Ogden, J. D. Pound, B. K. Batth, S. Owens, I. Johannessen, K. Wood, and C. D. Gregory (2005)
J. Immunol. 174, 3015-3023
   Abstract »    Full Text »    PDF »
Structures of APRIL-Receptor Complexes: LIKE BCMA, TACI EMPLOYS ONLY A SINGLE CYSTEINE-RICH DOMAIN FOR HIGH AFFINITY LIGAND BINDING.
S. G. Hymowitz, D. R. Patel, H. J. A. Wallweber, S. Runyon, M. Yan, J. Yin, S. K. Shriver, N. C. Gordon, B. Pan, N. J. Skelton, et al. (2005)
J. Biol. Chem. 280, 7218-7227
   Abstract »    Full Text »    PDF »
Importance of Cellular Microenvironment and Circulatory Dynamics in B Cell Immunotherapy.
Q. Gong, Q. Ou, S. Ye, W. P. Lee, J. Cornelius, L. Diehl, W. Y. Lin, Z. Hu, Y. Lu, Y. Chen, et al. (2005)
J. Immunol. 174, 817-826
   Abstract »    Full Text »    PDF »
Proinflammatory mediators elicit secretion of the intracellular B-lymphocyte stimulator pool (BLyS) that is stored in activated neutrophils: implications for inflammatory diseases.
P. Scapini, A. Carletto, B. Nardelli, F. Calzetti, V. Roschke, F. Merigo, N. Tamassia, S. Pieropan, D. Biasi, A. Sbarbati, et al. (2005)
Blood 105, 830-837
   Abstract »    Full Text »    PDF »
Genetics of lupus nephritis.
B R Lauwerys and E K Wakeland (2005)
Lupus 14, 2-12
   Abstract »    PDF »
Homeostatic cell-cycle control by BLyS: Induction of cell-cycle entry but not G1/S transition in opposition to p18INK4c and p27Kip1.
X. Huang, M. Di Liberto, A. F. Cunningham, L. Kang, S. Cheng, S. Ely, H.-c. Liou, I. C. M. MacLennan, and S. Chen-Kiang (2004)
PNAS 101, 17789-17794
   Abstract »    Full Text »    PDF »
B Cells Expressing Bcl-2 and a Signaling-Impaired BAFF-Specific Receptor Fail to Mature and Are Deficient in the Formation of Lymphoid Follicles and Germinal Centers.
Z. S. M. Rahman and T. Manser (2004)
J. Immunol. 173, 6179-6188
   Abstract »    Full Text »    PDF »
Expression of BLyS and its receptors in B-cell non-Hodgkin lymphoma: correlation with disease activity and patient outcome.
A. J. Novak, D. M. Grote, M. Stenson, S. C. Ziesmer, T. E. Witzig, T. M. Habermann, B. Harder, K. M. Ristow, R. J. Bram, D. F. Jelinek, et al. (2004)
Blood 104, 2247-2253
   Abstract »    Full Text »    PDF »
Rapid Response of Marginal Zone B Cells to Viral Particles.
D. Gatto, C. Ruedl, B. Odermatt, and M. F. Bachmann (2004)
J. Immunol. 173, 4308-4316
   Abstract »    Full Text »    PDF »
Inverse association between circulating APRIL levels and serological and clinical disease activity in patients with systemic lupus erythematosus.
W Stohl, S Metyas, S-M Tan, G S Cheema, B Oamar, V Roschke, Y Wu, K P Baker, and D M Hilbert (2004)
Ann Rheum Dis 63, 1096-1103
   Abstract »    Full Text »    PDF »
B Cell-Activating Factor Belonging to the TNF Family Acts through Separate Receptors to Support B Cell Survival and T Cell-Independent Antibody Formation.
S. Shulga-Morskaya, M. Dobles, M. E. Walsh, L. G. Ng, F. MacKay, S. P. Rao, S. L. Kalled, and M. L. Scott (2004)
J. Immunol. 173, 2331-2341
   Abstract »    Full Text »    PDF »
Construction and Function of Two Cys146-Mutants with High Activity, Derived from Recombinant Human Soluble B Lymphocyte Stimulator.
G. Chen, S. Peng, M. Zou, H. Xu, D. Xu, and J. Wang (2004)
J. Biochem. 136, 73-79
   Abstract »    Full Text »    PDF »
B Cell Positive Selection: Road Map to the Primary Repertoire?.
M. P. Cancro and J. F. Kearney (2004)
J. Immunol. 173, 15-19
   Abstract »    Full Text »    PDF »
A therapeutic role for BLyS antagonists.
W Stohl (2004)
Lupus 13, 317-322
   Abstract »    PDF »
Engineering an APRIL-specific B Cell Maturation Antigen.
D. R. Patel, H. J. A. Wallweber, J. Yin, S. K. Shriver, S. A. Marsters, N. C. Gordon, M. A. Starovasnik, and R. F. Kelley (2004)
J. Biol. Chem. 279, 16727-16735
   Abstract »    Full Text »    PDF »
BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone.
J. Moreaux, E. Legouffe, E. Jourdan, P. Quittet, T. Reme, C. Lugagne, P. Moine, J.-F. Rossi, B. Klein, and K. Tarte (2004)
Blood 103, 3148-3157
   Abstract »    Full Text »    PDF »
Impaired IgA class switching in APRIL-deficient mice.
E. Castigli, S. Scott, F. Dedeoglu, P. Bryce, H. Jabara, A. K. Bhan, E. Mizoguchi, and R. S. Geha (2004)
PNAS 101, 3903-3908
   Abstract »    Full Text »    PDF »
BAFF/BLyS can potentiate B-cell selection with the B-cell coreceptor complex.
H. Hase, Y. Kanno, M. Kojima, K. Hasegawa, D. Sakurai, H. Kojima, N. Tsuchiya, K. Tokunaga, N. Masawa, M. Azuma, et al. (2004)
Blood 103, 2257-2265
   Abstract »    Full Text »    PDF »
BAFF production by antigen-presenting cells provides T cell co-stimulation.
B. Huard, L. Arlettaz, C. Ambrose, V. Kindler, D. Mauri, E. Roosnek, J. Tschopp, P. Schneider, and L. E. French (2004)
Int. Immunol. 16, 467-475
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)