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Science 16 April 1999:
Vol. 284. no. 5413, pp. 505 - 507
DOI: 10.1126/science.284.5413.505
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Reports

Regulation of the Mammalian Pineal by Non-rod, Non-cone, Ocular Photoreceptors

Robert J. Lucas, 1* Melanie S. Freedman, 1 Marta Muñoz, 2 José-M. Garcia-Fernández, 2 Russell G. Foster 1

In mammals, ocular photoreceptors mediate an acute inhibition of pineal melatonin by light. The effect of rod and cone loss on this response was assessed by combining the rd mutation with a transgenic ablation of cones (cl) to produce mice lacking both photoreceptor classes. Despite the loss of all known retinal photoreceptors, rd/rd cl mice showed normal suppression of pineal melatonin in response to monochromatic light of wavelength 509 nanometers. These data indicate that mammals have additional ocular photoreceptors that they use in the regulation of temporal physiology.

1 Department of Biology, Sir Alexander Fleming Building, Imperial College of Science, Technology and Medicine, London, SW7 2AZ, UK.
2 Departmento de Morfologia y Biologia Cellular, Universidad de Oviedo, Oviedo 33072, Spain.
*   To whom correspondence should be addressed. E-mail: r.j.lucas{at}ic.ac.uk

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