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Science 9 April 1999:
Vol. 284. no. 5412, p. 239
DOI: 10.1126/science.284.5412.239

News Focus

PSYCHOPHARMACOLOGY:
Drug Therapies for Depression: From MAO Inhibitors to Substance P

Martin Enserink

Antidepressants have evolved through several generations since the 1950s, each a huge improvement over its predecessor--or so advocates have claimed. But a government-sponsored study published last month confirmed what other analyses had shown before: The fashionable antidepressants of the 1990s are no more effective than those of previous generations. The newer drugs do have a plus, however: fewer side effects.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)