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Science 2 April 1999:
Vol. 284. no. 5411, pp. 162 - 167
DOI: 10.1126/science.284.5411.162
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Reports

Dynamic Control of CaMKII Translocation and Localization in Hippocampal Neurons by NMDA Receptor Stimulation

Kang Shen, Tobias Meyer *

Calcium-calmodulin-dependent protein kinase II (CaMKII) is thought to increase synaptic strength by phosphorylating postsynaptic density (PSD) ion channels and signaling proteins. It is shown that N-methyl-D-aspartate (NMDA) receptor stimulation reversibly translocates green fluorescent protein-tagged CaMKII from an F-actin-bound to a PSD-bound state. The translocation time was controlled by the ratio of expressed beta -CaMKII to alpha -CaMKII isoforms. Although F-actin dissociation into the cytosol required autophosphorylation of or calcium-calmodulin binding to beta -CaMKII, PSD translocation required binding of calcium-calmodulin to either the alpha - or beta -CaMKII subunits. Autophosphorylation of CaMKII indirectly prolongs its PSD localization by increasing the calmodulin-binding affinity.

Department of Cell Biology and Department of Pharmacology and Cancer Biology, Box 3709, Duke University Medical Center, Durham, NC 27710, USA.
*   To whom correspondence should be addressed. E-mail: tobias{at}cellbio.duke.edu

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Mechanism and Regulation of Calcium/Calmodulin-dependent Protein Kinase II Targeting to the NR2B Subunit of the N-Methyl-D-aspartate Receptor.
S. Strack, R. B. McNeill, and R. J. Colbran (2000)
J. Biol. Chem. 275, 23798-23806
   Abstract »    Full Text »    PDF »
Activation of Ca2+/Calmodulin-dependent Protein Kinase II within Post-synaptic Dendritic Spines of Cultured Hippocampal Neurons.
N. Inagaki, M. Nishizawa, N. Arimura, H. Yamamoto, Y. Takeuchi, E. Miyamoto, K. Kaibuchi, and M. Inagaki (2000)
J. Biol. Chem. 275, 27165-27171
   Abstract »    Full Text »    PDF »
Protein Kinase C Activation Modulates alpha -Calmodulin Kinase II Binding to NR2A Subunit of N-Methyl-D-Aspartate Receptor Complex.
F. Gardoni, C. Bellone, F. Cattabeni, and M. Di Luca (2001)
J. Biol. Chem. 276, 7609-7613
   Abstract »    Full Text »    PDF »
Inositol 1,4,5-Trisphosphate 3-Kinase A Associates with F-actin and Dendritic Spines via Its N Terminus.
M. J. Schell, C. Erneux, and R. F. Irvine (2001)
J. Biol. Chem. 276, 37537-37546
   Abstract »    Full Text »    PDF »
Cellular Signaling through Multifunctional Ca2+/Calmodulin-dependent Protein Kinase II.
T. R. Soderling, B. Chang, and D. Brickey (2001)
J. Biol. Chem. 276, 3719-3722
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Glutamate-induced transient modification of the postsynaptic density.
A. Dosemeci, J.-H. Tao-Cheng, L. Vinade, C. A. Winters, L. Pozzo-Miller, and T. S. Reese (2001)
PNAS 98, 10428-10432
   Abstract »    Full Text »    PDF »


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