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Science 2 April 1999:
Vol. 284. no. 5411, pp. 143 - 147
DOI: 10.1126/science.284.5411.143
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Reports

Multilineage Potential of Adult Human Mesenchymal Stem Cells

Mark F. Pittenger, 1* Alastair M. Mackay, 1 Stephen C. Beck, 1 Rama K. Jaiswal, 1 Robin Douglas, 1 Joseph D. Mosca, 1 Mark A. Moorman, 1 Donald W. Simonetti, 1 Stewart Craig, 1 Daniel R. Marshak 12

Human mesenchymal stem cells are thought to be multipotent cells, which are present in adult marrow, that can replicate as undifferentiated cells and that have the potential to differentiate to lineages of mesenchymal tissues, including bone, cartilage, fat, tendon, muscle, and marrow stroma. Cells that have the characteristics of human mesenchymal stem cells were isolated from marrow aspirates of volunteer donors. These cells displayed a stable phenotype and remained as a monolayer in vitro. These adult stem cells could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages. Individual stem cells were identified that, when expanded to colonies, retained their multilineage potential.

1 Osiris Therapeutics, 2001 Aliceanna Street, Baltimore, MD 21231-3043, USA.
2 Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.
*   To whom correspondence should be addressed. E-mail: mpittenger{at}osiristx.com

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Increased Energy Expenditure and Insulin Sensitivity in the High Bone Mass {Delta}FosB Transgenic Mice.
G. C. Rowe, C. S. Choi, L. Neff, W. C. Horne, G. I. Shulman, and R. Baron (2009)
Endocrinology 150, 135-143
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Engraftment potential of human placenta-derived mesenchymal stem cells after in utero transplantation in rats.
C.-P. Chen, S.-H. Liu, J.-P. Huang, J. D. Aplin, Y.-H. Wu, P.-C. Chen, C.-S. Hu, C.-C. Ko, M.-Y. Lee, and C.-Y. Chen (2009)
Hum. Reprod. 24, 154-165
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Mesenchymal stem cells induce mature dendritic cells into a novel Jagged-2-dependent regulatory dendritic cell population.
B. Zhang, R. Liu, D. Shi, X. Liu, Y. Chen, X. Dou, X. Zhu, C. Lu, W. Liang, L. Liao, et al. (2009)
Blood 113, 46-57
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The nuclear lamina promotes telomere aggregation and centromere peripheral localization during senescence of human mesenchymal stem cells.
V. Raz, B. J. Vermolen, Y. Garini, J. J. M. Onderwater, M. A. Mommaas-Kienhuis, A. J. Koster, I. T. Young, H. Tanke, and R. W. Dirks (2008)
J. Cell Sci. 121, 4018-4028
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Mechanical Strain Inhibits Adipogenesis in Mesenchymal Stem Cells by Stimulating a Durable {beta}-Catenin Signal.
B. Sen, Z. Xie, N. Case, M. Ma, C. Rubin, and J. Rubin (2008)
Endocrinology 149, 6065-6075
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