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Science 19 March 1999:
Vol. 283. no. 5409, pp. 1923 - 1927
DOI: 10.1126/science.283.5409.1923
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Reports

Rapid Dendritic Morphogenesis in CA1 Hippocampal Dendrites Induced by Synaptic Activity

M. Maletic-Savatic, R. Malinow, K. Svoboda

Activity shapes the structure of neurons and their circuits. Two-photon imaging of CA1 neurons expressing enhanced green fluorescent protein in developing hippocampal slices from rat brains was used to characterize dendritic morphogenesis in response to synaptic activity. High-frequency focal synaptic stimulation induced a period (longer than 30 minutes) of enhanced growth of small filopodia-like protrusions (typically less than 5 micrometers long). Synaptically evoked growth was long-lasting and localized to dendritic regions close (less than 50 micrometers) to the stimulating electrode and was prevented by blockade of N-methyl-D-aspartate receptors. Thus, synaptic activation can produce rapid input-specific changes in dendritic structure. Such persistent structural changes could contribute to the development of neural circuitry.

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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Synaptopodin-deficient mice lack a spine apparatus and show deficits in synaptic plasticity.
T. Deller, M. Korte, S. Chabanis, A. Drakew, H. Schwegler, G. G. Stefani, A. Zuniga, K. Schwarz, T. Bonhoeffer, R. Zeller, et al. (2003)
PNAS 100, 10494-10499
   Abstract »    Full Text »    PDF »
Synapse disassembly.
B. A. Eaton and G. W. Davis (2003)
Genes & Dev. 17, 2075-2082
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NMDA-Dependent Proteolysis of Presynaptic Adhesion Molecule L1 in the Hippocampus by Neuropsin.
K. Matsumoto-Miyai, A. Ninomiya, H. Yamasaki, H. Tamura, Y. Nakamura, and S. Shiosaka (2003)
J. Neurosci. 23, 7727-7736
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Activity-Regulated Dynamic Behavior of Early Dendritic Protrusions: Evidence for Different Types of Dendritic Filopodia.
C. Portera-Cailliau, D. T. Pan, and R. Yuste (2003)
J. Neurosci. 23, 7129-7142
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Brain-Derived Neurotrophic Factor Mediates Activity-Dependent Dendritic Growth in Nonpyramidal Neocortical Interneurons in Developing Organotypic Cultures.
X. Jin, H. Hu, P. H. Mathers, and A. Agmon (2003)
J. Neurosci. 23, 5662-5673
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p250GAP, a Novel Brain-enriched GTPase-activating Protein for Rho Family GTPases, Is Involved in the N-Methyl-D-aspartate Receptor Signaling.
T. Nakazawa, A. M. Watabe, T. Tezuka, Y. Yoshida, K. Yokoyama, H. Umemori, A. Inoue, S. Okabe, T. Manabe, and T. Yamamoto (2003)
Mol. Biol. Cell 14, 2921-2934
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