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Science 19 March 1999:
Vol. 283. no. 5409, pp. 1923 - 1927
DOI: 10.1126/science.283.5409.1923
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Reports

Rapid Dendritic Morphogenesis in CA1 Hippocampal Dendrites Induced by Synaptic Activity

M. Maletic-Savatic, R. Malinow, K. Svoboda

Activity shapes the structure of neurons and their circuits. Two-photon imaging of CA1 neurons expressing enhanced green fluorescent protein in developing hippocampal slices from rat brains was used to characterize dendritic morphogenesis in response to synaptic activity. High-frequency focal synaptic stimulation induced a period (longer than 30 minutes) of enhanced growth of small filopodia-like protrusions (typically less than 5 micrometers long). Synaptically evoked growth was long-lasting and localized to dendritic regions close (less than 50 micrometers) to the stimulating electrode and was prevented by blockade of N-methyl-D-aspartate receptors. Thus, synaptic activation can produce rapid input-specific changes in dendritic structure. Such persistent structural changes could contribute to the development of neural circuitry.

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

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Brain-Derived Neurotrophic Factor Mediates Activity-Dependent Dendritic Growth in Nonpyramidal Neocortical Interneurons in Developing Organotypic Cultures.
X. Jin, H. Hu, P. H. Mathers, and A. Agmon (2003)
J. Neurosci. 23, 5662-5673
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p250GAP, a Novel Brain-enriched GTPase-activating Protein for Rho Family GTPases, Is Involved in the N-Methyl-D-aspartate Receptor Signaling.
T. Nakazawa, A. M. Watabe, T. Tezuka, Y. Yoshida, K. Yokoyama, H. Umemori, A. Inoue, S. Okabe, T. Manabe, and T. Yamamoto (2003)
Mol. Biol. Cell 14, 2921-2934
   Abstract »    Full Text »    PDF »
Coincidence Detection in Pyramidal Neurons Is Tuned by Their Dendritic Branching Pattern.
A. T. Schaefer, M. E. Larkum, B. Sakmann, and A. Roth (2003)
J Neurophysiol 89, 3143-3154
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Synchronized Formation and Remodeling of Postsynaptic Densities: Long-Term Visualization of Hippocampal Neurons Expressing Postsynaptic Density Proteins Tagged with Green Fluorescent Protein.
T. Ebihara, I. Kawabata, S. Usui, K. Sobue, and S. Okabe (2003)
J. Neurosci. 23, 2170-2181
   Abstract »    Full Text »    PDF »
Associative Memory Formation Increases the Observation of Dendritic Spines in the Hippocampus.
B. Leuner, J. Falduto, and T. J. Shors (2003)
J. Neurosci. 23, 659-665
   Abstract »    Full Text »    PDF »


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